CISBIC Sub-project 1: Glycomics of Mycobacterium bovis and Campylobacter jejuni

The overall aim of sub-project 1 is to develop models that will allow the prediction the effect of changes to the pathogen genome on expression of glycosylated surface molecules involved in triggering the innate immune response of the host.


  • Campylobacter jejuni
  • Mycobacterium bovis



For more information about the outputs from this project or to discuss data reuse please contact

CISBIC Sub-project 1

Project Members

  • Prof Stephen Muggleton
  • Prof Brendan Wren
  • Prof Michael Sternberg
  • Dr Emily Kay (biology)
  • Dr Victor Lesk (modelling)
  • Alireza Tamaddoni-Nezhad (modelling)
  • Dr Adrian Cootes (modelling)
  • Hiroake Watanabe (modelling)
  • Dr Richard Barton (core facility)
  • Dr Paul Hitchen (core facility)
  • Dr Frances Turner (statistics)


  • Interactive Glycomics Workbench (Lesk)
    The Workbench for Integrative Systems Biology is a portal-based workbench for interdisciplinary systems biology projects
  • Metabolomics Network Browser (Cootes)
    Web-based tool for the visualization and interrogation of Campylobacter jejuni glycomics pathway
  • Progol (Tamaddoni-Nezhad)
    Progol code and interpreter to perform Inductive Logic Programming using a Prolog knowledge base
  • PINALOG (Sternberg)
    PINALOG is a novel approach to align two protein-protein interaction (PPI) networks which combines information available for the proteins in the networks, including sequence, function and network topology


  • Prolog database (Lesk)
    Prolog clauses representing background knowledge relating to Campylobacter capsule formation
  • BµG@Sbase microarray experiment 155 (Turner)
    A comparison of the transcript profiles of mutants in capsule locus genes from Campylobacter jejuni strain 13362 compared to wild type
  • BµG@Sbase microarray experiment 158 (Turner)
    Treatment of Campylobacter jejuni wild type strain NCTC 13362 with various infection or environmental mimic perturbations
  • BµG@Sbase microarray experiment 159 (Turner)
    Transcriptional profiles of capsule locus mutants compared to wild type Campylobacter jejuni strain NCTC 13362. RNA was extracted after incubation optimized to give maximal capsule expression in the wild type cells
  • Campylobacter mutant capsule NMR (Barton, prepublication)
    Metabolomic characterisations of Campylobacter jejuni mutants as determined by 1H NMR




  • FASEB Summer Conference on Microbial Polysaccharides, Arizona, USA (Hitchen, 2008)
  • Learning and Inference in Computational Systems Biology, Glasgow, UK (Tamaddoni-Nezhad, 2008)
  • CISBIC International Advisory Board meeting (Muggleton, 2010)
  • Integrative Bioinformatics (Lesk, 2011)
  • KAUST conference on Quantitative Biology (Lesk, 2011)
  • FASEB Summer Conference on Microbial Polysaccharides, Arizona, USA (Hitchen, 2011)