In this section
@article{Zeng:2018:10.1002/anie.201802309,
author = {Zeng, F and Wu, Y and Li, X and Ge, X and Guo, Q and Lou, X and Cao, Z and Hu, B and Long, NJ and Mao, Y and Li, C},
doi = {10.1002/anie.201802309},
journal = {Angewandte Chemie International Edition},
pages = {5808--5812},
title = {Custom-made ceria nanoparticles show a neuroprotective effect by modulating phenotypic polarization of the microglia},
url = {http://dx.doi.org/10.1002/anie.201802309},
volume = {57},
year = {2018}
}
TY - JOUR
AB - The neuroprotective effect of ceria nanoparticles in the context of brain disorders has been explained by their antioxidant effect. However, the in-depth mechanism remains unknown. As resident immune cells in the brain, microglia exert a variety of functional reprogramming termed as polarization in response to stress stimuli. Herein, custom-made ceria nanoparticles were developed and found to scavenge multiple reactive oxygen species with extremely high efficiency. These nanoparticles drove microglial polarization from a pro-inflammatory phenotype to an anti-inflammatory phenotype under pathological conditions. Pretreatment of these nanoparticles changed the microglial function from detrimental to protective for the neuronal cells by blocking the pro-inflammatory signaling. This work not only helps to elucidate the mechanism of ceria-nanoparticle-mediated neuroprotection but also provides a new strategy to rebalance the immuno-environment by switching the equilibrium of the phenotypic activation of microglia.
AU - Zeng,F
AU - Wu,Y
AU - Li,X
AU - Ge,X
AU - Guo,Q
AU - Lou,X
AU - Cao,Z
AU - Hu,B
AU - Long,NJ
AU - Mao,Y
AU - Li,C
DO - 10.1002/anie.201802309
EP - 5812
PY - 2018///
SN - 1521-3757
SP - 5808
TI - Custom-made ceria nanoparticles show a neuroprotective effect by modulating phenotypic polarization of the microglia
T2 - Angewandte Chemie International Edition
UR - http://dx.doi.org/10.1002/anie.201802309
UR - https://www.ncbi.nlm.nih.gov/pubmed/29575461
UR - http://hdl.handle.net/10044/1/58660
VL - 57
ER -
Professor Nick Long
Email: n.long@imperial.ac.uk
Telephone: +44 (0)20 7594 5781
501J
Molecular Sciences Research Hub
White City Campus
