BibTex format
@article{Huang:2023:10.1126/science.adf8141,
author = {Huang, W and Rodrigues, J and Bilgo, E and Tormo, JR and Challenger, J and Challenger, JD and De, Cozar-Gallardo C and Perez-Victoria, I and Reyes, F and Castaneda-Casado, P and Gnambani, EJ and Francois, de Sales Hien D and Konkobo, M and Urones, Ruano B and Coppens, I and Mendoza-Losana, A and Ballell, L and Diabate, A and Churcher, TS and Jacobs-Lorena, M},
doi = {10.1126/science.adf8141},
journal = {Science},
pages = {533--540},
title = {Delftia tsuruhatensis TC1 symbiont suppresses malaria transmission by anopheline mosquitoes},
url = {http://dx.doi.org/10.1126/science.adf8141},
volume = {381},
year = {2023}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Malaria control demands the development of a wide range of complementary strategies. We describe the properties of a naturally occurring, non–genetically modified symbiotic bacterium, Delftia tsuruhatensis TC1, which was isolated from mosquitoes incapable of sustaining the development of Plasmodium falciparum parasites. D. tsuruhatensis TC1 inhibits early stages of Plasmodium development and subsequent transmission by the Anopheles mosquito through secretion of a small-molecule inhibitor. We have identified this inhibitor to be the hydrophobic molecule harmane. We also found that, on mosquito contact, harmane penetrates the cuticle, inhibiting Plasmodium development. D. tsuruhatensis TC1 stably populates the mosquito gut, does not impose a fitness cost on the mosquito, and inhibits Plasmodium development for the mosquito’s life. Contained field studies in Burkina Faso and modeling showed that D. tsuruhatensis TC1 has the potential to complement mosquito-targeted malaria transmission control.
AU - Huang,W
AU - Rodrigues,J
AU - Bilgo,E
AU - Tormo,JR
AU - Challenger,J
AU - Challenger,JD
AU - De,Cozar-Gallardo C
AU - Perez-Victoria,I
AU - Reyes,F
AU - Castaneda-Casado,P
AU - Gnambani,EJ
AU - Francois,de Sales Hien D
AU - Konkobo,M
AU - Urones,Ruano B
AU - Coppens,I
AU - Mendoza-Losana,A
AU - Ballell,L
AU - Diabate,A
AU - Churcher,TS
AU - Jacobs-Lorena,M
DO - 10.1126/science.adf8141
EP - 540
PY - 2023///
SN - 1095-9203
SP - 533
TI - Delftia tsuruhatensis TC1 symbiont suppresses malaria transmission by anopheline mosquitoes
T2 - Science
UR - http://dx.doi.org/10.1126/science.adf8141
UR - https://www.science.org/doi/10.1126/science.adf8141
VL - 381
ER -