BibTex format
@article{Ngufor:2023:10.1186/s12936-023-04708-x,
author = {Ngufor, C and Fongnikin, A and Fagbohoun, J and Agbevo, A and Syme, T and Ahoga, J and Accrombessi, M and Protopopoff, N and Cook, J and Churcher, TS and Padonou, GG and Govoetchan, R and Akogbeto, M},
doi = {10.1186/s12936-023-04708-x},
journal = {Malaria Journal},
title = {Evaluating the attrition, fabric integrity and insecticidal durability of two dual active ingredient nets (Interceptor ® G2 and Royal® Guard): methodology for a prospective study embedded in a cluster randomized controlled trial in Benin},
url = {http://dx.doi.org/10.1186/s12936-023-04708-x},
volume = {22},
year = {2023}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - BackgroundFollowing the World Health Organization (WHO) endorsement of dual active ingredient (AI) nets, an increased uptake of pyrethroid-chlorfenapyr and pyrethroid-pyriproxyfen nets is expected. Studies evaluating their physical and insecticidal durability are essential for making programmatic and procurement decisions. This paper describes the methodology for a prospective study to evaluate the attrition, fabric integrity, insecticidal durability of Interceptor® G2 (alpha-cypermethrin-chlorfenapyr) and Royal Guard® (alpha-cypermethrin-pyriproxyfen), compared to Interceptor® (alpha-cypermethrin), embedded in a 3-arm cluster randomized controlled trial (cRCT) in the Zou Department of Benin.MethodsTen clusters randomly selected from each arm of the cRCT will be used for the study. A total of 750 ITNs per type will be followed in 5 study clusters per arm to assess ITN attrition and fabric integrity at 6-, 12-, 24- and 36-months post distribution, using standard WHO procedures. A second cohort of 1800 nets per type will be withdrawn every 6 months from all 10 clusters per arm and assessed for chemical content and biological activity in laboratory bioassays at each time point. Alpha-cypermethrin bioefficacy in Interceptor® and Royal Guard® will be monitored in WHO cone bioassays and tunnel tests using the susceptible Anopheles gambiae Kisumu strain. The bioefficacy of the non-pyrethroid insecticides (chlorfenapyr in Interceptor® G2 and pyriproxyfen in Royal Guard®) will be monitored using the pyrethroid-resistant Anopheles coluzzii Akron strain. Chlorfenapyr activity will be assessed in tunnel tests while pyriproxyfen activity will be assessed in cone bioassays in terms of the reduction in fertility of blood-fed survivors observed by dissecting mosquito ovaries. Nets withdrawn at 12, 24 and 36 months will be tested in experimental hut trials within the cRCT study area against wild free-flying pyrethroid resistant An. gambiae sensu lato to i
AU - Ngufor,C
AU - Fongnikin,A
AU - Fagbohoun,J
AU - Agbevo,A
AU - Syme,T
AU - Ahoga,J
AU - Accrombessi,M
AU - Protopopoff,N
AU - Cook,J
AU - Churcher,TS
AU - Padonou,GG
AU - Govoetchan,R
AU - Akogbeto,M
DO - 10.1186/s12936-023-04708-x
PY - 2023///
SN - 1475-2875
TI - Evaluating the attrition, fabric integrity and insecticidal durability of two dual active ingredient nets (Interceptor ® G2 and Royal® Guard): methodology for a prospective study embedded in a cluster randomized controlled trial in Benin
T2 - Malaria Journal
UR - http://dx.doi.org/10.1186/s12936-023-04708-x
VL - 22
ER -