BibTex format
@article{Martin:2024:10.1371/journal.pgph.0002586,
author = {Martin, JL and Messenger, LA and Rowland, M and Mosha, FW and Bernard, E and Kisamo, M and Limbe, S and Hape, P and Thickstun, C and Steven, C and Moshi, O and Shirima, B and Matowo, NS and Mosha, JF and Dee, DP and Churcher, TS and Kulkarni, MA and Manjurano, A and Protopopoff, N},
doi = {10.1371/journal.pgph.0002586},
journal = {PLOS Global Public Health},
title = {Bio-efficacy of field aged novel class of long-lasting insecticidal nets, against pyrethroid-resistant malaria vectors in Tanzania: a series of experimental hut trials},
url = {http://dx.doi.org/10.1371/journal.pgph.0002586},
volume = {4},
year = {2024}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - New classes of long-lasting insecticidal nets (LLINs), have been recommended by the World Health Organization (WHO) to control malaria vectors resistant to pyrethroid insecticides. This study was nested in a large-scale cluster-randomized controlled trial conducted (cRCT) in Tanzania. A series of experimental hut trials (EHTs) aimed to evaluate the bio-efficacy of trial LLINs on mosquito indicators most pertinent to malaria transmission over 3 years of use in the community in order to better understand the outcomes of the cRCT. The following field-collected LLINs were assessed: 1) Olyset Plus (combining piperonyl butoxide synergist and permethrin), 2) Interceptor G2 (chlorfenapyr and alpha-cypermethrin), 3) Royal Guard (pyriproxyfen and alpha-cypermethrin), 4) Interceptor (alpha-cypermethrin only) conducted in parallel with 5) a new Interceptor, and 6) an untreated net. Thirty nets of each type were withdrawn from the community at 12, 24, and 36 months after distribution and used for the EHTs. Pre-specified outcomes were 72-hour mortality for Interceptor G2, 24-hour mortality for Olyset Plus, and fertility based on egg development stage for Royal Guard. Overall, Interceptor G2 LLINs induced higher 72-hour mortality compared to standard LLINs of the same age up to12 months (44% vs 21%, OR: 3.5, 95% CI: 1.9–6.6, p-value < 0.001), and 24-hour mortality was only significantly higher in Olyset Plus when new (OR: 13.6, 95%CI: 4.4–41.3, p-value < 0.001) compared to standard LLINs but not at 12 months (17% vs 13%; OR: 2.1, 95% CI: 1.0–4.3; p-value = 0.112). A small, non-significant effect of pyriproxyfen on Anopheles fertility was observed for Royal Guard up to 12 months (75% vs 98%, OR: 1.1, 95% CI: 0.0–24.9, p-value = 0.951). There was no evidence of a difference in the main outcomes for any of the new classes of LLINs at 24 and 36 months compared to standard LLINs. Interceptor G2 LLINs showed superior bio-efficacy compared to standard LLINs
AU - Martin,JL
AU - Messenger,LA
AU - Rowland,M
AU - Mosha,FW
AU - Bernard,E
AU - Kisamo,M
AU - Limbe,S
AU - Hape,P
AU - Thickstun,C
AU - Steven,C
AU - Moshi,O
AU - Shirima,B
AU - Matowo,NS
AU - Mosha,JF
AU - Dee,DP
AU - Churcher,TS
AU - Kulkarni,MA
AU - Manjurano,A
AU - Protopopoff,N
DO - 10.1371/journal.pgph.0002586
PY - 2024///
SN - 2767-3375
TI - Bio-efficacy of field aged novel class of long-lasting insecticidal nets, against pyrethroid-resistant malaria vectors in Tanzania: a series of experimental hut trials
T2 - PLOS Global Public Health
UR - http://dx.doi.org/10.1371/journal.pgph.0002586
UR - https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0002586
VL - 4
ER -