Key focuses

• Biological sample handling and preparation methods for clinical matrices
• Nuclear magnetic resonance spectroscopy for metabolic profiling and quantification
• Chromatographic separations of complex sample matrices
• Mass spectrometry for metabolic profiling and targeted quantification
• Molecular imaging for spatially resolved characterisation of tissue metabolite composition
• Data extraction methods and tools for high fidelity representation of spectrometric data
• Statistical analysis methods tools for the exploration of metabolic data
• Metabolite identification and de novo structure elucidation
• Education in key metabolomics technologies, methods, and data analysis approaches

Facilities and major programmes

• National Phenome Centre
• BRC Molecular Phenomics programme of the Imperial Biomedical Research Centre (BRC)
• MAP/UK

Training courses

• NIHR E-learning course
• Hands-on NMR Spectroscopy for Metabolic Profiling
• Hands-on Data Analysis for Metabolic Profiling
• Hands-on LC-MS for Metabolic Profiling

Section leadership

Head of  Bioanalytical Chemistry - Dr Matthew Lewis

As the Chief Operations Officer for the MRC-NIHR Phenome Centre (NPC), Clinical Phenotyping Centre (CPC), and the Director of Metabolic Profiling  for the Division of Systems Medicine, I am responsible for operational management and oversight of all research collaborations from design to delivery, as well as the development and execution of analytical research strategies.

Find out more about Dr Matthew Lewis