General Biomedical Research

  • Regulation of insulin secretion hotspots by the GLP-1 receptor
  • Optimisation of an ultra fast assay for metabolic profiling: application to clinical studies
  • Can Non-Invasive Vagus Nerve Stimulation alter the Cholinergic Metabolome in Parkinson’s Disease patients?
  • The feasibility and accuracy of a markerless motion capture for measuring parameters related to both normal and osteoarthritic gait and daily activities.
  • Wearable microneedle aptasensor of psychiatric biomarkers in mental health monitoring
  • Generating a Methyl-Proteomics Library for Studying Protein Methylation in Cancer
  • Immune-regulatory role of IL-27 axis in liver injury
  • Development and optimization of proteomic and metabolomic analysis of biological samples using Laser Desorption Rapid Evaporative Ionisation Mass Spectrometry
  • NNAT aggregation and loss of heterogeneity as causative factors in beta cell dysfunction in diabetes
  • Towards elucidation of 3D myocardial microstructure by ex-vivo Diffusion Tensor Cardiac Magnetic Resonance and 3D Histology
  • Developing a chick chorioallantoic membrane (CAM) assay as an xenograft model to study soft-tissue sarcoma drug development
  • Molecular mechanisms underpinning the extensive, multi-organelle dysfunction caused by the toxin L-amino acid oxidase
  • The role of mTORC2 in regulation of hESC stiffness and cell fate
  • Transient PiggyBac-based Genome Engineering to Produce Human Pluripotent Stem Cells
  • AstraZeneca Sponsored Project: Proteomic analysis of human mesenchymal stem cell cross-talk with haematopoietic stem cells in 3 dimensional niche of complex in vitro model of bone marrow

Anaesthetics, Pain Medicine and Intensive Care

  • Investigating the importance of microvesicle-delivered FADD on epithelial cell function during ventilator-induced lung injury
  • Evaluation of a novel medical device to prevent epidural hyperthermia
  • Evidence Synthesis to Inform Neuropathic Pain Mangement
  • Modelling labour contraction pain through Electrical muscle stimulation.
  • The role of the nuclear enzyme mitogen- and stress-activated kinase 1 in noxious heat sensitivity of primary sensory neutrons
  • Mechanisms of monocyte de-activation by neutrophil extracellular vesicles in sepsis
  • Modulation of neutrophil extracellular vesicle pro-inflammatory activity by complement
  • The effects of blocking MSK1 on tissue inflammation and wound healing
  • Neutrophil extracellular trap production in severe febrile illness in children
  • Preclinical investigation of brain injury due to carbon monoxide poisoning

Bacterial Pathogenesis and Infection

  • Analysis of OMV-based vaccine strategies to combat Avian Pathogenic Escherichia coli (APEC)
  • Exploring the mechanism of Salmonella effector kinase, SteC, in the mammalian host
  • Investigating the role of TRIM E3 ligase proteins during Salmonella infection
  • Poisons and antidotes - defining the antibacterial effector repertoire of Pseudomonas aeruginosa’s T6SS
  • Pathogenicity island transduction and the evolution of bacterial pathogens
  • Impact of targeting inhibitory immune receptors by urogenital bacterial pathogens.
  • Using a Fluorescence-activated cell sorting (FACS)-based screen to identify novel factors that regulate c-di-AMP production in Staphylococcus aureus.
  • Understanding golden staph and its friends: genomic analysis of staphylococcal nasal carriage in UK military personnel at high risk of skin infections
  • The role of KRT10 in invasive bacterial infections of childhood
  • Understanding the pathogenesis of the priority nosocomial pathogen Enterobacter cloacae

Data Science

  • Physics-Informed Neural Networks to Predict Blood Glucose Levels in Patients with Type-I Diabetes
  • Explainable prognostic models for progressive pulmonary fibrosis
  • Border Rendering Feature Orthogonal Network for Blood Vessel Segmentation
  • Revealing the hidden fingerprints of drug exposure and metabolism in population-scale metabolomics data by statistical correlation and database development.
  • Integrative analysis of single-cell RNA-Seq data to explore the association of mosaic loss of chromosome Y with idiopathic pulmonary fibrosis
  • Exploring Expression Patterns and Shared Genetic Mechanisms in MS through Integrative Genetic Analysis
  • Unpaired Style Mapping using Generative Models Techniques for Medical Image Segmentation
  • Characteristics of Urinary Pathogens in People Living with Dementia
  • Integrating transcriptomic, epigenomic, and transcription factor binding data to unravel the function of TSPO in microglia.
  • Machine Learning Applications to Radiomics of Early Pregnancy Ultrasound To Predict Miscarriage

Epidemiology, Evolution and Control of Infectious Diseases

  • A systematic review and estimation of the effects of temperature on yellow fever vector development and survival
  • Estimating the impact of cholera interventions on disease burden in Somalia
  • Evolution and global spatio-temporal spread of Coxsackievirus A6
  • Modelling the spread of drug resistance to a key malaria prevention drug in children
  • Are complex models necessary to realistically measure epidemic spread?
  • Quantifying the contribution of surveillance datastreams in informing key epidemiological drivers of the Covid-19 pandemic in the UK
  • Applying machine learning to the automated interpretation of genomic epidemiology data
  • Towards HIV elimination: a mathematical model-based examination of transmission in Manicaland, Zimbabwe
  • The potential impact of HIV pre-exposure prophylaxis (PrEP) on HIV outcomes in Western Africa: a mathematical modelling analysis

Microbiome in Health and Disease

  • One-Health surveillance of emerging antifungal resistance across a UK cohort of farms, homes and green-waste recyclers
  • Optimisation of storage and transportation of high throughput DESI swab testing of vaginal dysbiosis.
  • Exploring the impact of Mediterranean and Western diet on the gut bacterial metabolism
  • Westernisation of the faecal metabolic profiles
  • Measuring bacterial sugar nutrients in faecal samples by LC-MS/MS to assess the risk of pathogenic gut colonisation upon administration of antibiotics
  • The role of cervicovaginal microbiome on cervical carcinogenesis
  • Testing and developing novel drying matrices for Intestinal Microbiota Transplant capsules.
  • Can stabilized stool samples be used for bacterial culture, basic proteomics and clinical diagnostics?

Molecular Basis of Human Disease

  • How does proteostasis restrict toxic protein aggregates from damaging the cell?
  • The role of Mannose-6-phosphate receptor (M6PR) in human pancreatic β-cells
  • Investigating the role of CD63 in human adipose stem cells
  • How the bacterial type II secretion system powers toxin release
  • The Tight adherence molecular machine builds pili and drives bacterial
  • Novel neuromodulators from the gut microbiome
  • Biosensor screening using a bacterial synthetic memory circuit
  • Spatial biosensor development for the inflammatory biomarker sialic acid
  • Using wildDISCO to characterise disruption of sleep-wake cycles in Alzheimer's disease
  • Investigating the impact of genomic diversity on cell wall chemistry in Aspergillus fumigatus

Respiratory and Cardiovascular Science

  • Characterisation of lung pericytes and how inflammation can shape them
  • The role of mitochondrial dynamics in cardiac inflammatory phenotype
  • Identification of the miRNA markers of cardiac fibrosis from heart failure patients using new nanopore technology
  • Investigating the role of MAP4 and microtubule dynamics in heart failure.
  • How does PDE4B involve in the β2AR-cAMP compartmentation during hypoosmotic stress?
  • A systematic review and meta-analysis of trial evidence evaluating behavioural interventions to reduce asthma symptoms
  • Interactions of Immune Sub-populations with Cardiac Cell Types in Post-Infarct Human and Mouse Hearts
  • Role of sympathetic neurons in regulating cardiomyocyte conductance and electrical properties.
  • Aspergillus-specific immune responses in chronic respiratory disease
  • Characterization of MSC-derived exosomes from 3D culture systems

You can download a full list of the projects and supervisors for each stream below.

MRes BMR 2023-24 Projects (all streams)