Projects

General Biomedical Research

  • Arginine deprivation as a metabolic therapy for brain tumours: investigating protein changes

  • Can we identify people at risk of muscle wasting by analysing their blood?

  • Modulating Membrane Binding and Aggregation of α-Synuclein by Therapeutic Peptide SS-31

  • Regulation of beta cell incretin responses by the lipid microenvironment

  • Investigating the role of AMP-activated protein kinase in Pdgfrβ+ adipose-derived stem cells

  • Investigating effect of HOXC13 missense mutation on the expression of genes associated with hair growth

  • Predictive modelling of neuro-cognitive outcome in critically ill patients

  • Synthesis, Characterization and Study of in vitro Degradation of Polyacetal Microparticles

  • "AstraZeneca sponsored project:

  • Advancing oncology drug safety assessment: Metabolomic and secretomic profiling of a bone marrow organ-on-a-chip model"

  • Probing the association between circadian rhythms, dysregulated expression of cold- induced proteins and Alzheimer’s disease

  • Identification of the function of hSKI patient mutations in telomere maintenance.

  • Analysis of congenital heart defects in down syndrome using induced pluripotent stem cells

  • Novel ubiquitylation mechanisms at the interface of host immunity and bacterial pathogenesis

  • Studying the mechanotransduction signalling pathway mediated by the Retinoic Acid Receptor Beta (RAR-B) in pancreatic cancer

  • Towards drug design for allosteric inhibition of DDR1 kinase

  • Exploring the relationship between urine inflammatory markers and urinary tract infection in people living with dementia

  • Unveiling the impact of bacterial metabolites on human coronary smooth muscle cells relevant to atherosclerosis

  • Regulation of insulin sensitivity by miRNAs miR-424 or miR-542

  • "Metabolic control of fibrosis of the liver – a spatial metabolomics approach

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  • Live imaging transcriptional dynamics during gut specification in zebrafish

  • Biomechanics of hepatic stellate cells

  • Probing protein 3D structure by mass spectrometry

  • Characterization of the impact of a diabetogenic high fat diet on the mouse metabolic profile and myocardial vasculature

  • The role of the tumor susceptibility gene 101 in HIV particle assembly kinetics

  • Cannabis-derived products for reliving pain in burn injury

  • Collective cell migration – follow thy neighbour

  • Investigation of inflammatory responses in alveolar epithelial and endothelial cells in REVAS-on-a-chip

  • Unveiling the impact of bacterial metabolites on human coronary smooth muscle cells relevant to atherosclerosis

  • Development of mass spectrometry imaging to study tissue metabolism

  • Development of stiffness-tuneable PDMS substrates to study the biomechanics of macrophage phagocytosis in liver fibrosis

  • The Role of Neuroinflammation, Gliosis & Neurodegeneration in Blast-traumatic brain injury

  • Matching microbiomes to metabonomes at an individual level

  • Investigating the role of ANP32 in Influenza A virus replication

  • Investigating the mechanism for plasma membrane mechanosensing. Implications for exocytosis in cancer cells.

  • Epitranscriptional changes drive increased survival of M. smegmatis upon exposure to aminoglycosides

  • Using Morphological Measures in the UK Biobank to Predict Cancer Incidence

  • (AstraZeneca Sponsored) B. Exploratory data analysis of physicochemical properties for understanding PROTACS oral absorption.

  • Identification of the function of hSKI patient mutations in telomere maintenance.

  • Dissecting the proteasome function in colorectal cancer

  • A Systematic Review of preclinical studies of noble gases as novel treatments for brain injury:

  • Characterising lipid remodelling in cirrhosis of the liver

  • Understanding the role of the SARS-CoV2 virus processing and viral entry genes on vascular endothelial and smooth muscle cells

  • Sleep and Gait Analysis in triple-axis accelerometer data derived from Brain Tumour Patients enrolled into the BrainWear Study

  • Microfluidic platform for modelling of pulmonary vascular cell interactions

  • B cells and auto-antibodies in heart disease

  • Sex and Reproductive Differences in the Drosophila Gut

  • Investigating the Metabolic Programming of the Germinal Centre Reactions

  • Building a molecular model of the Phage PhiKZ nv-polymerase

  • AstraZeneca Sponsored Project: Drivers of renal and cardiovascular toxicity in patients with cardiovascular disease

  • Exploring the protective efficacy of mosquito net mosaics

  • Host -omics integration to understand infectious disease (including COVID19)

  • Pre-clinical characterisation of oligonucleotide-based drug delivery systems for gene therapies.

  • Identification of Major Depressive Disorder subtypes using molecular phenotyping

  • Identification and characterisation of inhibitors that block the RAS/p110α

  • The expression of Claudins in borderline ovarian tumours

  • Understanding how ibuprofen-like drugs cause heart attacks and strokes by effects on the kidney and blood vessels

Anaesthetics, Pain Medicine and Intensive Care

  • Mechanistic exploration of the role of secreted extracellular Cyclophilin A in the pathogenesis of ventilator-induced lung injury
  • A Systematic Review of preclinical studies of noble gases as novel treatments for brain injury
  • The involvement of necroptosis in hypoxic-ischaemic encephalopathy
  • Feasibility of using phytocannabinoids to control pain in burn injury
  • Compositions for organ graft preservation and methods of use
  • Investigation of microvesicles as indicators of systemic inflammation and metabolic status in severe burns injury patients
  • Drug design for allosteric inhibition of DDR1 kinase
  • A Systematic Review of preclinical studies of noble gases as novel treatments for brain injury
  • BALF microvesicles as biomarkers and modulators of inflammation during ARDS
  • ClpP-dependent Hypoxia-induced Mitochondrial Autophagy in Renal cancer cell
  • The involvement of necroptosis and mitophagy in hypoxic-ischaemic encephalopathy
  • The role of DAMPs in the development of renal fibrosis
  • Cytokines and chemokines in human burn tissues
  • BALF microvesicles as biomarkers and modulators of inflammation during ARDS

Bacterial Pathogenesis and Infection

  • Understanding the role of the respiratory microbiome in regulation of anti-bacterial defences
  • Discovering new commensal bacteria from the human microbiota that protect against AMR infection and combat pathological inflammation
  • Development of a novel anti-bacterial therapeutic approach
  • Identifying genetic determinants of tolerance and persistence in uropathogenic E. coli
  • Rapid detection of pathogens using MALDI mass spectrometry
  • Understanding how phage-inducible chromosomal islands (PICIs) spread in nature
  • Modulation of the antibacterial T6SS impact and activity in mixed populations
  • Characterising a novel family of mobile genetic elements involved in bacterial virulence.
  • Characterising a novel family of mobile genetic elements involved in bacterial virulence.
  • Phenotypic antibiotic resistance in the nosocomial pathogen Enterobacter cloacae.
  • Colistin heteroresistance in Enterobacter cloacae
  • Characterising a novel family of mobile genetic elements involved in bacterial virulence.
  • Investigation of mobile genetic elements responsible for antimicrobial resistance patterns in pregnant women colonizing GBS isolates in African countries
  • Investigating the role of Salmonella effector SteE
  • Structular characterization of a bacterial gun, the type VI secretion system
  • Investigation of mobile genetic elements responsible for antimicrobial resistance patterns in pregnant women colonizing GBS isolates in African countries
  • Investigating the role of Burkholderia effector TssM
  • Investigating the function of Group B Streptococcus and CEACAM1 receptors interactions at lung epithelia
  • Phenotypic antibiotic resistance in the nosocomial pathogen Enterobacter cloacae.
  • Discovering new regulatory circuits that control inflammasome responses to infection
  • Characterising an emergent lineage of M1T1 Streptococcus pyogenes in England
  • Investigating the role of TRIM proteins in antibacterial immunity
  • Does the host environment drive antibiotic resistance?
  • The role of the major variant transcriptome in uropathogenic Escherichia coli
  • How does the host environment affect colistin resistance?
  • The effects of different antibiotics on metabolites produced by the gut microbiota
  • Modelling the ecology of Streptococcus pneumoniae to inform future vaccine strategies
  • Unraveling mechanisms of phenotypic resistance to aminoglycosides in mycobacteria
  • Understanding and exploiting Group A streptococcal anti-chemotactic proteases

Data Science

  • Deep Learning-assisted Enhancement of Mass Spectrometry Hyperspectral Images – image restoration and super resolution
  • A framework for spatial metabolomics data analysis of fatty liver disease and liver fibrosis
  • What-the-bug?! Named entity recognition of bacteria and microbiota in biomedical text using recurrent neural networks
  • Investigating regulatory mutations in 100,000 Genomes Project recessive mitochondrial disease cases
  • Transforming interpretation of metabolomics data by improving integrative pathway analysis tools
  • Histological image analysis for tissue diagnostics using deep learning
  • NEnzymeR2N2: Named Entity Recognition for enzymes in biomedical text using Recurrent Neural Networks
  • scRNAseq analysis of immune cells in the uterus at term (labour vs not in labour)
  • BM Toolkit: A tool to mediate successful translation of biomarkers from bench to clinic.
  • Window to the brain: Towards a language-independent AI-predictor of dementia
  • Analysis of multimodal imaging data to predict the likelihood of developing dementia
  • Prediction of copy number variants from whole-genome sequencing data
  • Hidden fat: Identifying the relationship between pericardial fat and cardiovascular mortality using cardiac MRI
  • Molecular networking for the fusion of multiple untargeted LC-MS metabolomic datasets to power the understanding of diseases
  • Using deep learning to enhance mass spectrometry hyperspectral imaging data - restoration & super-resolution
  • GlioCoVa
  • AstraZeneca Sponsored Project: Exploration of 3D explainable Deep Learning methods for Classification of disease on medical images
  • Transforming interpretation of metabolomics data by improving integrative pathway analysis tools
  • (AstraZeneca Sponsored) A. Exploratory data analysis of physicochemical properties for understanding PROTACS oral absorption.
  • Machine Learning for DNA Storage
  • Identifying resistance-causing mutations in pathogenic bacteria with machine learning
  • Machine intelligence applied to routinely gathered flow cytometry data to identify predictors of outcome amongst patients with COVID19
  • Machine-Learning and Patient stratification to accelerate the clinical translation of Lymphoma drug development
  • MetaboListem: Metabolite named entity recognition using recurrent neural networks
  • Automatisation of oxygen consumption calculations within electronic patient medical records
  • Development of computational tools for automated deconvolution of NMR spectra from complex sample types
  • REaltime DAta Synthesisand Analysis (REDASA) of Scientific Literature
  • Machine Learning and Image Processing in Liver Ultrasound Images
  • AI-based histological image analysis for tissue diagnostics
  • Big data molecular networking for the fusion of multiple untargeted LC-MS metabolomic datasets to power the understanding of diseases
  • “A picture is worth a thousand words”: translating images found in biomedical literature to text
  • Scoring radiological features for lung CT scans
  • Natural Language Processing for mental health applications: analytics for the SHOUT conversation database
  • Simulations of epidemic spreading in hospital using patient trajectories
  • Find The Assay: named entity recognition of techniques used for genome-wide and metabolome-wide association study data generation
  • Deep learning approaches to enhance mass spectrometry hyperspectral images : towards spatial and spectral super resolution
  • COVID-19 and cancer: can we kill two birds with one stone?
  • AstraZeneca Sponsored Project: Defining the transcriptional profile of in vitro differentiated haematopoietic cells and identifying ‘toxicity signatures’ of oncology therapeutics
  • AstraZeneca Sponsored Project: Elucidating immunometabolism in non-alcoholic steatohepatitis by identification of immune cell clusters and linkage to metabolites
  • (Title to be updated) An in silico model of liver toxicity using the biological modelling tool COPASI
  • Identification of metabolites in LC-MS untargeted datasets using machine learning
  • AstraZeneca Sponsored Project: Making sense of multidimensional data to improve the safety of cancer drugs
  • Machine intelligence applied to routinely gathered flow cytometry data to identify predictors of outcome amongst patients with COVID19

Microbiome in Health and Disease

  • Evaluation of recombinant Bile salt hydrolase (rBSH) to treat C. difficile infections.
  • How do probiotics and autologous FMT affect the gut microbial metabolism and composition post antibiotics?
  • Role of microbial metabolites in fatty liver disease development.
  • Can Medium Chain Fatty Acids (MFCA) do the same job as Antibiotics, but without the risk of resistance arising?
  • Investigating the role of choline metabolism in tumorigenesis using mouse organoids
  • Investigating the genotoxic effect of tyramine on mouse-derived organoids
  • The impact of vancomycin and ciprofloxacin on the gut bacterial composition and metabolic function
  • Discovering new commensal bacteria that protect against AMR infection and combat pathological inflammation
  • Swabbing microbiota-derived proteases in Inflammatory Bowel Diseases
  • Investigating the neural pathways regulating the metabolic response to protein
  • DEVELOPMENT OF 2ND GENERATION FAECAL MICROBIOTA TRANSPLANT TREATMENTS
  • Role of microbial metabolites in fatty liver disease development.
  • Bacterial localization and function in the mammalian gut
  • The role of the microbiome in sex differences in glucose and appetite regulatory systems
  • Can the gut microbiota influence cholesterol responses to dietary saturated fat?
  • Investigating the role of circulating bacterial metabolites in the response to nutritional intake.
  • Quantitation of essential amino acids in African Populations by LC-MS/MS
  • Trimethylamine as a kinase inhibitor in immunometabolism pathways: beneficial high-jacking of host signalling machinery in low-grade inflammation and insulin resistance
  • The role of the microbiome and immune microenvironment on HPV infection and cervical carcinogenesis
  • Investigating a Faecal Immunochemical Test (FIT) – Laser Assisted - Rapid Evaporative Ionisation Mass Spectrometry (LA-REIMS) coupled setup for colorectal cancer detection
  • Exploring Aspergillus fumigatus gene expression during co-infection with Pseudomonas aeruginosa
  • Investigating the metabolic effects of a high fibre diet on the Alaskan faecal microbiota using a colon cancer mouse model
  • Metabolomic analysis of Clostridium perfringens, a putative pathobioint in Crohn's disease
  • Uncovering the influence of brain connectivity in anti-depressant treatment response
  • Quantification of faecal short chain fatty acid levels in Africans
  • Surface enhanced Raman spectroscopy probes for identification and manipulation of bacteria
  • Investigating how sensing of short chain fatty acids in the gut regulates hormonal and neuronal signalling to the brain.
  • Impact of the microbial metabolites on colon cancer
  • Investigating how GPR119 signaling regulates fat intake and metabolism
  • Biomechanical Responses of Pancreatic Cancer Cells in Biochemically Relevant Environments

Molecular Basis of Human Disease

  • Impact of GWAS-identified genetic variants in pancreatic beta cells
  • Modelling the role of LRRK2 mediated lysosomal degradation in liver disease using patient specific human stem cells.
  • Probing the association between circadian rhythms and Alzheimer’s disease in patient-derived cellular models
  • Building DNA damage response complexes at the break site
  • Synergistic interaction between antibody-drug conjugates in high grade serous ovarian cancer
  • Molecular mechanisms of ubiquitylation and protein turnover in preventing inflammatory disease
  • Purifying Proteins From Cell-Free Reactions Directly onto Grids for Cryo-EM Analysis
  • Use of scRNA-seq data to uncover temporal signatures during progenitor cell differentiation
  • Structural characterisation of the transcription factor controlling the T6SS in Pseudomonas aeruginosa
  • Using electrophysiology towards understanding neuropsychiatric diseases
  • STUDY of EPICARDIAL SIGNALING MODULATION in MODELS of MAJOR DISEASE-CAUSING STRESSORS: DIABETES and ISCHEMIA REOXYGENATION
  • Evaluating the application of SABER-FISH for bacterial detection and function
  • Molecular investigations to uncover the structural basis of ATR/Mec1 inhibitors
  • Investigating inhibitors against tumour suppressor ATR/Tel1, a validated drug target
  • Biomechanical responses of liver cancer cells in biochemically relevant environments
  • Role of miR-125b in pancreatic beta cell mass and gene expression
  • Studying the role of hypoxia inducible factor (HIF) in the response of cancer cells to low pH values.
  • Structure determination of the bacterial type II secretion system

Respiratory and Cardiovascular Science

  • Investigation into the impact of inflammation on vascular remodelling in the lungs, role of pericytes?
  • AstraZeneca Sponsored Project: Evaluating a Human in vitro Bone Marrow Toxicity Assay for Improved Clinical Translatability during Drug Development
  • Electrophysiological remodelling associated with obesity and fat tissue
  • Examination of plasticity of alveolar epithelial cells - role of Wnt-signalling
  • Studying the role of microtubules association proteins (MAPs) in localised mRNA translation in cardiomyocytes.
  • "Mitochondrial dynamics in cardiac immunopathology.
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  • Optimisation of 3D matrix for single cell contraction of unique vascular smooth muscle cells grown from blood
  • Human pluripotent stem cell derived left ventricle cardiomyocytes: Contractility and cAMP response to β-adrenergic stimulation study
  • Characterisation of the omnipolar electrogram signal algorithm
  • Chronic thoracotomy pain in transplant patients: towards a multicentre international study
  • Improvements to a novel and excellent haemostatic materials
  • ‘Role of Sympathetic Neurons in the Control of cAMP response in HiPSC – Derived Cardiomyocytes’
  • Investigation of the effect of age, allergen and/or viral exposure to the contribution of airway remodelling in mouse models of asthma
  • Patterns of Rgl1 induction during inflammation across vascular and pathogen sensing cells
  • Regulation of lymphatic endothelial cell metabolism by the transcription factor ERG
  • Investigating the capacity of viral and bacterial stimuli to promote DC dependent CD4 T cell differentiation
  • Using living organ slices to understand the cardiovascular and renal side effects caused ibuprofen and aspirin-type drugs
  • Investigate induction of airway remodeling in a neonatal murine model of severe recurrent RSV infection
  • Assessing the value of unipolar, bipolar and omnipolar mapping in interpreting the contact cardiac electrogram
  • Patient Adherence Rates to Continuous Positive Airway Pressure Treatment (CPAP) for Obstructive Sleep Apnoea Syndrome before and after the coronavirus pandemic
  • Using tissue-selective mRNA delivery vectors to understand a novel cardio-protective pathway in the lung
  • Multidisciplinary discovery of new therapeutic targets in heart failure through intercellular signalling pathways.
  • Ventricular electrophysiological remodelling in pulmonary hypertension
  • Generation of an in vitro model of liver sinusoidal endothelial cell (LSEC)
  • Electrophysiological remodelling associated with adiposity
  • Unveiling the impact of bacterial metabolites on human coronary endothelial cells exposed to a proinflammatory environment
  • Investigation of cAMP signalling compartmentation mechanism via beta adrenergic signalling pathway in cardiomyocytes using Nano- tweezers
  • Comparison of novel microRNAs and UDCA/ INT-777 as treatments of cardiac fibrosis.
  • Investigation of cardiac stretch and the caveolae microdomain
  • The role of cardiac mesenchymal stromal cells in the protection of human iPS-derived cardiomyocytes from ischemia reperfusion injury
  • Determine the impact of HIF2a on Human Umbilical Vein Endothelial Cells' (HUVECs) gap junction gene expression
  • Investigation of liver disease cis-regulatory networks
  • Identifying electrogram markers of myocardial structure
  • Stem cell therapy for cardiac regeneration with polyhydroxylalkanoate patches: a rodent myocardial infarcted heart model

Epidemiology, Evolution and Control of Infectious Diseases

  • Using mathematical modelling to determine the potential population-level benefits of developing a HSV-2 vaccine against HSV-2 infection and/or disease in Brazil.
  • Unifying epidemiological, ecological and genomic data to identify drivers of arbovirus outbreaks
  • Influence of vaccination and sociodemographic factors on the regional variation of COVID-19 transmission in the UK
  • Quantifying transmissibility in the early stages of an emerging epidemic: exploring methodological differences and corrections
  • Graph-based methods for understanding bacterial pathogen evolution in response to vaccine and antibiotic selection
  • Risk factors for HIV-related stigma in Zimbabwean communities: an analysis of data from the Manicaland Study
  • A platform for reproducing and comparing drug resistance predictions in bacteria
  • Characterising the role of competition in the emergence of a higher-fitness multidrug-resistant pneumococcus in South Africa
  • Modelling gonorrhoea vaccination to inform trial design, predict population-level impact from trial data, and inform policy to combat AMR
  • ‘Rescuing a tainted image?’: Impact of community level ART coverage on stigmatising attitudes held towards PLHIV in Manicaland, eastern Zimbabwe
  • Inference with epidemiological and genetic models by using GPU accelerated methods, with
  • application to SARS‐CoV‐2 transmission in the UK
  • Using serological data to characterise Lassa fever transmission
  • Real-time Analysis and Short-Term Projections of COVID-19 transmission in the Philippines
  • Understanding the impact of control and elimination interventions on onchocerciasis-associated epilepsy