Biomedical research projects
Projects
General Biomedical Research
- Regulation of insulin secretion hotspots by the GLP-1 receptor
- Optimisation of an ultra fast assay for metabolic profiling: application to clinical studies
- Can Non-Invasive Vagus Nerve Stimulation alter the Cholinergic Metabolome in Parkinson’s Disease patients?
- The feasibility and accuracy of a markerless motion capture for measuring parameters related to both normal and osteoarthritic gait and daily activities.
- Wearable microneedle aptasensor of psychiatric biomarkers in mental health monitoring
- Generating a Methyl-Proteomics Library for Studying Protein Methylation in Cancer
- Immune-regulatory role of IL-27 axis in liver injury
- Development and optimization of proteomic and metabolomic analysis of biological samples using Laser Desorption Rapid Evaporative Ionisation Mass Spectrometry
- NNAT aggregation and loss of heterogeneity as causative factors in beta cell dysfunction in diabetes
- Towards elucidation of 3D myocardial microstructure by ex-vivo Diffusion Tensor Cardiac Magnetic Resonance and 3D Histology
- Developing a chick chorioallantoic membrane (CAM) assay as an xenograft model to study soft-tissue sarcoma drug development
- Molecular mechanisms underpinning the extensive, multi-organelle dysfunction caused by the toxin L-amino acid oxidase
- The role of mTORC2 in regulation of hESC stiffness and cell fate
- Transient PiggyBac-based Genome Engineering to Produce Human Pluripotent Stem Cells
- AstraZeneca Sponsored Project: Proteomic analysis of human mesenchymal stem cell cross-talk with haematopoietic stem cells in 3 dimensional niche of complex in vitro model of bone marrow
Anaesthetics, Pain Medicine and Intensive Care
- Investigating the importance of microvesicle-delivered FADD on epithelial cell function during ventilator-induced lung injury
- Evaluation of a novel medical device to prevent epidural hyperthermia
- Evidence Synthesis to Inform Neuropathic Pain Mangement
- Modelling labour contraction pain through Electrical muscle stimulation.
- The role of the nuclear enzyme mitogen- and stress-activated kinase 1 in noxious heat sensitivity of primary sensory neutrons
- Mechanisms of monocyte de-activation by neutrophil extracellular vesicles in sepsis
- Modulation of neutrophil extracellular vesicle pro-inflammatory activity by complement
- The effects of blocking MSK1 on tissue inflammation and wound healing
- Neutrophil extracellular trap production in severe febrile illness in children
- Preclinical investigation of brain injury due to carbon monoxide poisoning
Bacterial Pathogenesis and Infection
- Analysis of OMV-based vaccine strategies to combat Avian Pathogenic Escherichia coli (APEC)
- Exploring the mechanism of Salmonella effector kinase, SteC, in the mammalian host
- Investigating the role of TRIM E3 ligase proteins during Salmonella infection
- Poisons and antidotes - defining the antibacterial effector repertoire of Pseudomonas aeruginosa’s T6SS
- Pathogenicity island transduction and the evolution of bacterial pathogens
- Impact of targeting inhibitory immune receptors by urogenital bacterial pathogens.
- Using a Fluorescence-activated cell sorting (FACS)-based screen to identify novel factors that regulate c-di-AMP production in Staphylococcus aureus.
- Understanding golden staph and its friends: genomic analysis of staphylococcal nasal carriage in UK military personnel at high risk of skin infections
- The role of KRT10 in invasive bacterial infections of childhood
- Understanding the pathogenesis of the priority nosocomial pathogen Enterobacter cloacae
Data Science
- Physics-Informed Neural Networks to Predict Blood Glucose Levels in Patients with Type-I Diabetes
- Explainable prognostic models for progressive pulmonary fibrosis
- Border Rendering Feature Orthogonal Network for Blood Vessel Segmentation
- Revealing the hidden fingerprints of drug exposure and metabolism in population-scale metabolomics data by statistical correlation and database development.
- Integrative analysis of single-cell RNA-Seq data to explore the association of mosaic loss of chromosome Y with idiopathic pulmonary fibrosis
- Exploring Expression Patterns and Shared Genetic Mechanisms in MS through Integrative Genetic Analysis
- Unpaired Style Mapping using Generative Models Techniques for Medical Image Segmentation
- Characteristics of Urinary Pathogens in People Living with Dementia
- Integrating transcriptomic, epigenomic, and transcription factor binding data to unravel the function of TSPO in microglia.
- Machine Learning Applications to Radiomics of Early Pregnancy Ultrasound To Predict Miscarriage
Epidemiology, Evolution and Control of Infectious Diseases
- A systematic review and estimation of the effects of temperature on yellow fever vector development and survival
- Estimating the impact of cholera interventions on disease burden in Somalia
- Evolution and global spatio-temporal spread of Coxsackievirus A6
- Modelling the spread of drug resistance to a key malaria prevention drug in children
- Are complex models necessary to realistically measure epidemic spread?
- Quantifying the contribution of surveillance datastreams in informing key epidemiological drivers of the Covid-19 pandemic in the UK
- Applying machine learning to the automated interpretation of genomic epidemiology data
- Towards HIV elimination: a mathematical model-based examination of transmission in Manicaland, Zimbabwe
- The potential impact of HIV pre-exposure prophylaxis (PrEP) on HIV outcomes in Western Africa: a mathematical modelling analysis
Microbiome in Health and Disease
- One-Health surveillance of emerging antifungal resistance across a UK cohort of farms, homes and green-waste recyclers
- Optimisation of storage and transportation of high throughput DESI swab testing of vaginal dysbiosis.
- Exploring the impact of Mediterranean and Western diet on the gut bacterial metabolism
- Westernisation of the faecal metabolic profiles
- Measuring bacterial sugar nutrients in faecal samples by LC-MS/MS to assess the risk of pathogenic gut colonisation upon administration of antibiotics
- The role of cervicovaginal microbiome on cervical carcinogenesis
- Testing and developing novel drying matrices for Intestinal Microbiota Transplant capsules.
- Can stabilized stool samples be used for bacterial culture, basic proteomics and clinical diagnostics?
Molecular Basis of Human Disease
- How does proteostasis restrict toxic protein aggregates from damaging the cell?
- The role of Mannose-6-phosphate receptor (M6PR) in human pancreatic β-cells
- Investigating the role of CD63 in human adipose stem cells
- How the bacterial type II secretion system powers toxin release
- The Tight adherence molecular machine builds pili and drives bacterial
pathogenesis - Novel neuromodulators from the gut microbiome
- Biosensor screening using a bacterial synthetic memory circuit
- Spatial biosensor development for the inflammatory biomarker sialic acid
- Using wildDISCO to characterise disruption of sleep-wake cycles in Alzheimer's disease
- Investigating the impact of genomic diversity on cell wall chemistry in Aspergillus fumigatus
Respiratory and Cardiovascular Science
- Characterisation of lung pericytes and how inflammation can shape them
- The role of mitochondrial dynamics in cardiac inflammatory phenotype
- Identification of the miRNA markers of cardiac fibrosis from heart failure patients using new nanopore technology
- Investigating the role of MAP4 and microtubule dynamics in heart failure.
- How does PDE4B involve in the β2AR-cAMP compartmentation during hypoosmotic stress?
- A systematic review and meta-analysis of trial evidence evaluating behavioural interventions to reduce asthma symptoms
- Interactions of Immune Sub-populations with Cardiac Cell Types in Post-Infarct Human and Mouse Hearts
- Role of sympathetic neurons in regulating cardiomyocyte conductance and electrical properties.
- Aspergillus-specific immune responses in chronic respiratory disease
- Characterization of MSC-derived exosomes from 3D culture systems
You can download a full list of the projects and supervisors for each stream below.
MRes BMR 2023-24 Projects (all streams)