In this section
@article{Williams:2008:10.1126/science.1160058,
author = {Williams, BR and Prabhu, VR and Hunter, KE and Glazier, CM and Whittaker, CA and Housman, DE and Amon, A},
doi = {10.1126/science.1160058},
journal = {Science},
pages = {703--709},
title = {Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells.},
url = {http://dx.doi.org/10.1126/science.1160058},
volume = {322},
year = {2008}
}
TY - JOUR
AB - Aneuploidy, an incorrect number of chromosomes, is the leading cause of miscarriages and mental retardation in humans and is a hallmark of cancer. We examined the effects of aneuploidy on primary mouse cells by generating a series of cell lines that carry an extra copy of one of four mouse chromosomes. In all four trisomic lines, proliferation was impaired and metabolic properties were altered. Immortalization, the acquisition of the ability to proliferate indefinitely, was also affected by the presence of an additional copy of certain chromosomes. Our data indicate that aneuploidy decreases not only organismal but also cellular fitness and elicits traits that are shared between different aneuploid cells.
AU - Williams,BR
AU - Prabhu,VR
AU - Hunter,KE
AU - Glazier,CM
AU - Whittaker,CA
AU - Housman,DE
AU - Amon,A
DO - 10.1126/science.1160058
EP - 709
PY - 2008///
SP - 703
TI - Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells.
T2 - Science
UR - http://dx.doi.org/10.1126/science.1160058
UR - https://www.ncbi.nlm.nih.gov/pubmed/18974345
VL - 322
ER -
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