BibTex format
@article{Dennis:2026:10.1126/science.adx6925,
author = {Dennis, TPW and Sulieman, JE and Nouredayem, M and Ashine, T and Ebstie, Y and Eyasu, A and Simma, EA and Zemene, E and Negash, N and Yigeremu, A and Assefa, M and Elzack, H and Dagne, A and Lukas, B and Bulto, MG and Fontaine, MC and Talignani, L and Enayati, A and Nikpoor, F and Al-Nazawi, AM and Al-Zahrani, MH and Khaireh, BA and Guelleh, S and Abdi, A-IA and Allan, R and Omondi, S and Abong'o, B and Milanoi, S and Ochomo, E and Ahmed, A and Samake, JN and Gimnig, JE and Rafferty, C and Ashraf, F and Pignatelli, P and Morris, M and Nagi, SC and Lucas, ER and Hernandez-Koutoucheva, A and Clarkson, CS and Doumbe-Belisse, P and Epstein, A and Brown, R and Wilson, AL and Reynolds, AM and Sherrard-Smith, E and Yewhalaw, D and Gadisa, E and Malik, E and Kafy, HT and Donnelly, MJ and Weetman, D},
doi = {10.1126/science.adx6925},
journal = {Science},
title = {The origin, history, and resistance architecture of an invasive urban malaria mosquito in Africa.},
url = {http://dx.doi.org/10.1126/science.adx6925},
volume = {393},
year = {2026}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - The invasive urban malaria vector Anopheles stephensi threatens 126 million city dwellers in Africa. Controlling An. stephensi requires greater understanding of its origin, invasion dynamics, and insecticide resistance mechanisms. Analysis of 645 whole genomes sampled across Africa, the Middle East, and Asia supports an invasion scenario in which an initial South Asian introduction established a bridgehead population in Djibouti, which seeded distinct invasion fronts in Sudan, Ethiopia/Kenya, and Yemen. These incursions show contrasting rates and routes of spread shaped by landscape topology. Insecticide resistance is predominantly mediated by metabolic detoxification genes, with resistance haplotypes and copy-number amplifications introduced from South Asia. These findings, alongside a companion genomic resource, enable genomic surveillance of An. stephensi spread and resistance to aid control strategies.
AU - Dennis,TPW
AU - Sulieman,JE
AU - Nouredayem,M
AU - Ashine,T
AU - Ebstie,Y
AU - Eyasu,A
AU - Simma,EA
AU - Zemene,E
AU - Negash,N
AU - Yigeremu,A
AU - Assefa,M
AU - Elzack,H
AU - Dagne,A
AU - Lukas,B
AU - Bulto,MG
AU - Fontaine,MC
AU - Talignani,L
AU - Enayati,A
AU - Nikpoor,F
AU - Al-Nazawi,AM
AU - Al-Zahrani,MH
AU - Khaireh,BA
AU - Guelleh,S
AU - Abdi,A-IA
AU - Allan,R
AU - Omondi,S
AU - Abong'o,B
AU - Milanoi,S
AU - Ochomo,E
AU - Ahmed,A
AU - Samake,JN
AU - Gimnig,JE
AU - Rafferty,C
AU - Ashraf,F
AU - Pignatelli,P
AU - Morris,M
AU - Nagi,SC
AU - Lucas,ER
AU - Hernandez-Koutoucheva,A
AU - Clarkson,CS
AU - Doumbe-Belisse,P
AU - Epstein,A
AU - Brown,R
AU - Wilson,AL
AU - Reynolds,AM
AU - Sherrard-Smith,E
AU - Yewhalaw,D
AU - Gadisa,E
AU - Malik,E
AU - Kafy,HT
AU - Donnelly,MJ
AU - Weetman,D
DO - 10.1126/science.adx6925
PY - 2026///
TI - The origin, history, and resistance architecture of an invasive urban malaria mosquito in Africa.
T2 - Science
UR - http://dx.doi.org/10.1126/science.adx6925
UR - https://www.ncbi.nlm.nih.gov/pubmed/42348676
VL - 393
ER -