In this section
@article{Fry:2008:10.1101/gad.1688508,
author = {Fry, RC and Svensson, JP and Valiathan, C and Wang, E and Hogan, BJ and Bhattacharya, S and Bugni, JM and Whittaker, CA and Samson, LD},
doi = {10.1101/gad.1688508},
journal = {Genes Dev},
pages = {2621--2626},
title = {Genomic predictors of interindividual differences in response to DNA damaging agents.},
url = {http://dx.doi.org/10.1101/gad.1688508},
volume = {22},
year = {2008}
}
TY - JOUR
AB - Human lymphoblastoid cells derived from different healthy individuals display considerable variation in their transcription profiles. Here we show that such variation in gene expression underlies interindividual susceptibility to DNA damaging agents. The results demonstrate the massive differences in sensitivity across a diverse cell line panel exposed to an alkylating agent. Computational models identified 48 genes with basal expression that predicts susceptibility with 94% accuracy. Modulating transcript levels for two member genes, MYH and C21ORF56, confirmed that their expression does indeed influence alkylation sensitivity. Many proteins encoded by these genes are interconnected in cellular networks related to human cancer and tumorigenesis.
AU - Fry,RC
AU - Svensson,JP
AU - Valiathan,C
AU - Wang,E
AU - Hogan,BJ
AU - Bhattacharya,S
AU - Bugni,JM
AU - Whittaker,CA
AU - Samson,LD
DO - 10.1101/gad.1688508
EP - 2626
PY - 2008///
SN - 0890-9369
SP - 2621
TI - Genomic predictors of interindividual differences in response to DNA damaging agents.
T2 - Genes Dev
UR - http://dx.doi.org/10.1101/gad.1688508
UR - https://www.ncbi.nlm.nih.gov/pubmed/18805990
VL - 22
ER -
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