In this section
@article{Palacek:2025:10.61373/gp025c.0041,
author = {Palacek, K and Carhart-Harris, R and Fabiano, N},
doi = {10.61373/gp025c.0041},
journal = {Genomic Psychiatry},
pages = {18--20},
title = {The salience network is functionally twice as large in depression: The first depression biomarker?},
url = {http://dx.doi.org/10.61373/gp025c.0041},
volume = {1},
year = {2025}
}
TY - JOUR
AB - <jats:p> <jats:bold>This commentary examines recent findings demonstrating that individuals with depression exhibit a functionally expanded salience network compared to non-depressed controls. Neuroimaging data reveals this network expansion predates symptom onset and remains stable regardless of symptom severity or treatment interventions. The authors propose this distinctive neural signature as a potential biomarker for depression risk, enabling earlier identification and intervention. They discuss three potential mechanisms underlying this expansion: compensatory network changes, genetic predisposition, and relative expansion secondary to atrophy in other brain regions. The commentary emphasizes the need to conceptualize depression as a disorder of neural connectivity rather than isolated neurotransmitter imbalances, with implications for developing targeted therapeutic approaches.</jats:bold> </jats:p>
AU - Palacek,K
AU - Carhart-Harris,R
AU - Fabiano,N
DO - 10.61373/gp025c.0041
EP - 20
PY - 2025///
SN - 2997-254X
SP - 18
TI - The salience network is functionally twice as large in depression: The first depression biomarker?
T2 - Genomic Psychiatry
UR - http://dx.doi.org/10.61373/gp025c.0041
UR - https://doi.org/10.61373/gp025c.0041
VL - 1
ER -
