In this section
@article{Blest-Hopley:2025,
author = {Blest-Hopley, G and Pasculli, G and Ruffell, SGD and Emmanuel, O and Pate, KM and Kettner, H and Roseman, L and Carhart-Harris, R},
journal = {Frontiers in Psychiatry},
title = {Improved mental health outcomes and normalized spontaneous EEG activity in veterans reporting a history of Traumatic Head Injuries following participation in a psilocybin retreat},
year = {2025}
}
TY - JOUR
AB - Introduction Psilocybin, a serotonergic psychedelic, has shown therapeutic potential in treating mental health disorders by, amongst the many effects, promoting neuroplasticity and reorganizing functional connectivity across cortical and subcortical networks involved in emotion and cognition. Veterans with traumatic brain injuries (TBI) often experience chronic neurological and psychological symptoms such as post-traumatic stress disorder (PTSD) and depression. This study investigates the effects of psilocybin administered in retreat settings on veterans with a history of TBI, focusing on mental health outcomes and changes in brain connectivity as measured by EEG. Methods A total of 21 participants were recruited through the Heroic Hearts Project, which facilitated access to two six-day psilocybin retreats in Jamaica. Before the retreat, participants underwent three individual and three group coaching sessions to prepare for the experience. During the retreat, two psilocybin ceremonies were held, spaced 48 hours apart. Participants received an initial dose of 1.5g to 3.5g of dried psilocybin mushrooms, with the option to increase the second dose up to 5g. Psilocybin was administered in a tea format, under the supervision of experienced facilitators. Psychological outcomes were assessed using validated questionnaires (PCL-5, PHQ-9, STAI) at baseline (four weeks pre-retreat) and four weeks post-retreat. Electroencephalography (EEG) was used to measure brainwave activity pre- and post-treatment. Paired t-tests were used to analyze changes in psychological scores, while EEG frequency band analysis assessed changes in brain function and connectivity. ResultsImprovements were observed across several mental health measures: PTSD (PCL-5 scores decreased by 50%, p=0.010), depression (PHQ-9 scores decreased by 65%, p<0.001), and anxiety (STAI scores decreased by 28%, p<0.001). EEG data showed decreased delta and theta power in frontal and temporal regions, indicating po
AU - Blest-Hopley,G
AU - Pasculli,G
AU - Ruffell,SGD
AU - Emmanuel,O
AU - Pate,KM
AU - Kettner,H
AU - Roseman,L
AU - Carhart-Harris,R
PY - 2025///
SN - 1664-0640
TI - Improved mental health outcomes and normalized spontaneous EEG activity in veterans reporting a history of Traumatic Head Injuries following participation in a psilocybin retreat
T2 - Frontiers in Psychiatry
ER -
