BibTex format
@article{Kanen:2025:ijnp/pyaf052.163,
author = {Kanen, J and Luppi, A and Luo, Q and Roseman, L and Cardinal, R and Robbins, T and Nutt, D and Carhart-Harris, R and den, Ouden H},
doi = {ijnp/pyaf052.163},
journal = {International Journal of Neuropsychopharmacology},
pages = {ii82--ii82},
title = {97. NEURAL AND BEHAVIORAL EVIDENCE FROM REINFORCEMENT LEARNING CONVERGE IN SUPPORT OF RELAXED BELIEFS UNDER LSD},
url = {http://dx.doi.org/10.1093/ijnp/pyaf052.163},
volume = {28},
year = {2025}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>The REBUS (RElaxed Beliefs Under pSychedelics) and the anarchic brain model of psychedelic drug action proposes that confidence in beliefs – and thus expectations (priors) – are relaxed under these drugs. The brain makes inferences to minimize surprise, or discrepant expectations and outcomes (prediction error [PE]), and better model the world. We recently showed that the non-specific 5-HT2A receptor agonist LSD heightened sensitivity to PEs, reflected by speeded updating of value representations following better and worse than expected outcomes. Indeed, events that are surprising are inherently less expected. There is evidence that LSD produces ego dissolution that is positively correlated with disintegration of the default mode network (DMN), assessed using resting state functional connectivity (RSFC), and is correlated inversely with alpha oscillatory power. The DMN has been proposed to be a seat at the ego’s table and decreased alpha power has been posited to reflect relaxation of the cognitive hierarchy, mediated by 5-HT2A receptors on deep layer V pyramidal neurons in cortex.</jats:p> </jats:sec> <jats:sec> <jats:title>Aims & Objectives</jats:title> <jats:p>Here we aim to demonstrate neural correlates of an objective, behaviorally derived marker of REBUS. Greater speed at which choice value increased following a reward PE – higher reward learning rates (RLRs) – was operationalized as enhanced sensitivity to surprise. We tested whether medial prefrontal cortex (mPFC) RSFC within the DMN – a region often associated with value – and diminished alpha power correlated significantly with the RLR.</jats:p> </jats:sec>
AU - Kanen,J
AU - Luppi,A
AU - Luo,Q
AU - Roseman,L
AU - Cardinal,R
AU - Robbins,T
AU - Nutt,D
AU - Carhart-Harris,R
AU - den,Ouden H
DO - ijnp/pyaf052.163
EP - 82
PY - 2025///
SN - 1461-1457
SP - 82
TI - 97. NEURAL AND BEHAVIORAL EVIDENCE FROM REINFORCEMENT LEARNING CONVERGE IN SUPPORT OF RELAXED BELIEFS UNDER LSD
T2 - International Journal of Neuropsychopharmacology
UR - http://dx.doi.org/10.1093/ijnp/pyaf052.163
UR - https://doi.org/10.1093/ijnp/pyaf052.163
VL - 28
ER -
