In this section
@article{Nutt:1989:10.1007/978-1-4899-1678-5_15,
author = {Nutt, D and Adinoff, B and Linnoila, M},
doi = {10.1007/978-1-4899-1678-5_15},
journal = {Recent Dev Alcohol},
pages = {283--313},
title = {Benzodiazepines in the treatment of alcoholism.},
url = {http://dx.doi.org/10.1007/978-1-4899-1678-5_15},
volume = {7},
year = {1989}
}
TY - JOUR
AB - This chapter comprises three sections that cover the main aspects of benzodiazepines and alcohol: (1) the basic pharmacology of benzodiazepines; (2) use of benzodiazepines in the treatment of withdrawal; and (3) the use of benzodiazepines in treating alcoholics. The basic studies suggest that a major site of action of alcohol may be the GABA/benzodiazepine receptor complex and that compensatory alterations in this complex may underly withdrawal. In the section on alcohol withdrawal, interactions between the GABA/benzodiazepine receptor complex, sympathetic nervous system, and hypothalamic-pituitary-adrenal axis are discussed. Use of benzodiazepines in the treatment of the alcohol withdrawal syndrome are reviewed, including the possibility that the benzodiazepines may prevent withdrawal-induced "kindling." Lastly, we review indications for, and efficacy of, benzodiazepines in long-term treatment of patients with alcoholism. Benzodiazepines are not indicated for the treatment of alcoholism. Furthermore, they have very few indications in alcoholics and their dependency-producing potency has to be appreciated when they are used in patients with alcoholism.
AU - Nutt,D
AU - Adinoff,B
AU - Linnoila,M
DO - 10.1007/978-1-4899-1678-5_15
EP - 313
PY - 1989///
SN - 0738-422X
SP - 283
TI - Benzodiazepines in the treatment of alcoholism.
T2 - Recent Dev Alcohol
UR - http://dx.doi.org/10.1007/978-1-4899-1678-5_15
UR - https://www.ncbi.nlm.nih.gov/pubmed/2564689
VL - 7
ER -
