BibTex format
@article{Colasanti:2012:10.1016/j.biopsych.2012.01.027,
author = {Colasanti, A and Searle, GE and Long, CJ and Hill, SP and Reiley, RR and Quelch, D and Erritzoe, D and Tziortzi, AC and Reed, LJ and Lingford-Hughes, AR and Waldman, AD and Schruers, KR and Matthews, PM and Gunn, RN and Nutt, DJ and Rabiner, EA},
doi = {10.1016/j.biopsych.2012.01.027},
journal = {Biol Psychiatry},
pages = {371--377},
title = {Endogenous opioid release in the human brain reward system induced by acute amphetamine administration},
url = {http://dx.doi.org/10.1016/j.biopsych.2012.01.027},
volume = {72},
year = {2012}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - BACKGROUND: We aimed to demonstrate a pharmacologically stimulated endogenous opioid release in the living human brain by evaluating the effects of amphetamine administration on [(11)C]carfentanil binding with positron emission tomography (PET). METHODS: Twelve healthy male volunteers underwent [(11)C]carfentanil PET before and 3 hours after a single oral dose of d-amphetamine (either a "high" dose, .5 mg/kg, or a sub-pharmacological "ultra-low" dose, 1.25 mg total dose or approximately .017 mg/kg). Reductions in [(11)C]carfentanil binding from baseline to post-amphetamine scans (DeltaBP(ND)) after the "high" and "ultra-low" amphetamine doses were assessed in 10 regions of interest. RESULTS: [(11)C]carfentanil binding was reduced after the "high" but not the "ultra-low" amphetamine dose in the frontal cortex, putamen, caudate, thalamus, anterior cingulate, and insula. CONCLUSIONS: Our findings indicate that oral amphetamine administration induces endogenous opioid release in different areas of human brain, including basal ganglia, frontal cortex areas, and thalamus. The combination of an amphetamine challenge and [(11)C]carfentanil PET is a practical and robust method to probe the opioid system in the living human brain.
AU - Colasanti,A
AU - Searle,GE
AU - Long,CJ
AU - Hill,SP
AU - Reiley,RR
AU - Quelch,D
AU - Erritzoe,D
AU - Tziortzi,AC
AU - Reed,LJ
AU - Lingford-Hughes,AR
AU - Waldman,AD
AU - Schruers,KR
AU - Matthews,PM
AU - Gunn,RN
AU - Nutt,DJ
AU - Rabiner,EA
DO - 10.1016/j.biopsych.2012.01.027
EP - 377
PY - 2012///
SN - 1873-2402
SP - 371
TI - Endogenous opioid release in the human brain reward system induced by acute amphetamine administration
T2 - Biol Psychiatry
UR - http://dx.doi.org/10.1016/j.biopsych.2012.01.027
UR - http://www.ncbi.nlm.nih.gov/pubmed/22386378
VL - 72
ER -
