BibTex format
@article{Savulich:2017:10.1038/tp.2017.34,
author = {Savulich, G and Riccelli, R and Passamonti, L and Correia, M and Deakin, JFW and Elliott, R and Flechais, RSA and Lingford-Hughes, AR and McGonigle, J and Murphy, A and Nutt, DJ and Orban, C and Paterson, LM and Reed, LJ and Smith, DG and Suckling, J and Tait, R and Taylor, EM and Sahakian, BJ and Robbins, TW and Ersche, KD},
doi = {10.1038/tp.2017.34},
journal = {TRANSLATIONAL PSYCHIATRY},
title = {Effects of naltrexone are influenced by childhood adversity during negative emotional processing in addiction recovery},
url = {http://dx.doi.org/10.1038/tp.2017.34},
volume = {7},
year = {2017}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Naltrexone is an opioid receptor antagonist used in the management of alcohol dependence. Although the endogenous opioid system has been implicated in emotion regulation, the effects of mu-opioid receptor blockade on brain systems underlying negative emotional processing are not clear in addiction. Individuals meeting criteria for alcohol dependence alone (n=18, alcohol) and in combination with cocaine and/or opioid dependence (n=21, alcohol/drugs) and healthy individuals without a history of alcohol or drug dependence (n=21) were recruited. Participants were alcohol and drug abstinent before entered into this double-blind, placebo-controlled, randomized, crossover study. Functional magnetic resonance imaging was used to investigate brain response while viewing aversive and neutral images relative to baseline on 50 mg of naltrexone and placebo. We found that naltrexone modulated task-related activation in the medial prefrontal cortex and functional connectivity between the anterior cingulate cortex and the hippocampus as a function of childhood adversity (for aversive versus neutral images) in all groups. Furthermore, there was a group-by-treatment-by-condition interaction in the right amygdala, which was mainly driven by a normalization of response for aversive relative to neutral images under naltrexone in the alcohol/drugs group. We conclude that early childhood adversity is one environmental factor that influences pharmacological response to naltrexone. Pharmacotherapy with naltrexone may also have some ameliorative effects on negative emotional processing in combined alcohol and drug dependence, possibly due to alterations in endogenous opioid transmission or the kappa-opioid receptor antagonist actions of naltrexone.
AU - Savulich,G
AU - Riccelli,R
AU - Passamonti,L
AU - Correia,M
AU - Deakin,JFW
AU - Elliott,R
AU - Flechais,RSA
AU - Lingford-Hughes,AR
AU - McGonigle,J
AU - Murphy,A
AU - Nutt,DJ
AU - Orban,C
AU - Paterson,LM
AU - Reed,LJ
AU - Smith,DG
AU - Suckling,J
AU - Tait,R
AU - Taylor,EM
AU - Sahakian,BJ
AU - Robbins,TW
AU - Ersche,KD
DO - 10.1038/tp.2017.34
PY - 2017///
SN - 2158-3188
TI - Effects of naltrexone are influenced by childhood adversity during negative emotional processing in addiction recovery
T2 - TRANSLATIONAL PSYCHIATRY
UR - http://dx.doi.org/10.1038/tp.2017.34
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000397228200006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
VL - 7
ER -
