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• Journal article
  NUTT DJ, LISTER RG, 1988,

  STRAIN DIFFERENCES IN RESPONSE TO A BENZODIAZEPINE RECEPTOR INVERSE AGONIST (FG 7142) IN MICE

  , PSYCHOPHARMACOLOGY, Vol: 94, Pages: 435-436, ISSN: 0033-3158
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  • Citations: 37
• Journal article
  Lister RG, Nutt DJ, 1988,

  RO 15-4513 and its interaction with ethanol.

  , Adv Alcohol Subst Abuse, Vol: 7, Pages: 119-123, ISSN: 0270-3106

  It has recently been claimed that RO 15-4513 selectively opposes some of the behavioral actions of ethanol. Our studies on the intrinsic effects of this compound have shown it to be proconvulsant and to reduce exploratory behavior in mice. In these respects RO 15-4513 resembles a benzodiazepine receptor partial inverse agonist. Such intrinsic actions may well explain its alcohol-antagonizing properties, and argue against its potential in humans. In addition to partially reversing the effects of ethanol, RO 15-4513 also partially reverses the behavioral effect of a barbiturate and completely reverses the effects of a benzodiazepine.

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• Journal article
  GLEITER CH, NUTT DJ, 1988,

  REPEATED ELECTROCONVULSIVE SHOCK INCREASES THE NUMBER OF [H-3] DESIPRAMINE BINDING-SITES IN RAT CEREBRAL-CORTEX

  , PSYCHOPHARMACOLOGY, Vol: 96, Pages: 426-427, ISSN: 0033-3158
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  • Citations: 6
• Journal article
  NUTT DJ, TAYLOR SC, LITTLE HJ, STANDING BL, GALE RGet al., 1988,

  CHANGES IN BENZODIAZEPINE GABA RECEPTOR COMPLEX FUNCTION IN BENZODIAZEPINE-TOLERANT MICE

  , PSYCHOPHARMACOLOGY, Vol: 95, Pages: 407-412, ISSN: 0033-3158
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  • Citations: 19
• Journal article
  Nutt DJ, Lister RG, 1988,

  Strain differences in response to a benzodiazepine receptor inverse agonist (FG 7142) in mice.

  , Psychopharmacology (Berl), Vol: 94, Pages: 335-336, ISSN: 0033-3158
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• Journal article
  GLEITER CH, NUTT DJ, 1988,

  REPEATED ELECTROCONVULSIVE SHOCK DOES NOT CHANGE [H-3] PAROXETINE BINDING TO THE 5-HT UPTAKE SITE IN RAT CORTICAL MEMBRANES

  , PSYCHOPHARMACOLOGY, Vol: 95, Pages: 68-70, ISSN: 0033-3158
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  • Citations: 18
• Journal article
  Linnoila M, Mefford I, Nutt D, Adinoff Bet al., 1987,

  NIH conference. Alcohol withdrawal and noradrenergic function.

  , Ann Intern Med, Vol: 107, Pages: 875-889, ISSN: 0003-4819

  Alcohol withdrawal syndrome is characterized by signs of overactivity of the sympathetic nervous system. Biochemical studies indicate that increased release of norepinephrine is associated with certain symptoms of alcohol withdrawal, and the severity of the withdrawal symptoms correlates positively with the amount of norepinephrine released. In the rat, the brain epinephrine concentration is reduced by alcohol, a phenomenon probably associated with both the intoxicating and rewarding effects of alcohol intake. Furthermore, intoxicating effects of alcohol can be reversed by inhibiting epinephrine synthesis in the rat brain. In this species, alcohol withdrawal is associated with profound depletion of epinephrine in the hypothalamus. When clonidine, a norepinephrine alpha-2-receptor agonist, was infused in alcoholics, these receptors were found to be subsensitive during alcohol withdrawal, and this subsensitivity may contribute to the syndrome. Repeated withdrawals may lead to "kindling" and thus further enhancement of noradrenergic overactivity. Pituitary responsiveness to corticotropin-releasing hormone, which is a central regulator of stress responses and increases the firing rate of brain noradrenergic neurons, is altered during alcohol withdrawal.

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• Journal article
  LINNOILA M, MEFFORD I, NUTT D, ADINOFF Bet al., 1987,

  ALCOHOL-WITHDRAWAL AND NORADRENERGIC FUNCTION

  , ANNALS OF INTERNAL MEDICINE, Vol: 107, Pages: 875-889, ISSN: 0003-4819
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  • Citations: 143
• Journal article
  NUTT D, GLUE P, STEWART A, 1987,

  PLATELET MONAMINE RECEPTOR-BINDING IN ALCOHOLICS DURING WITHDRAWAL

  , BRITISH JOURNAL OF ADDICTION, Vol: 82, Pages: 1253-1255, ISSN: 0952-0481
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  • Citations: 1
• Journal article
  GLEITER CH, NUTT DJ, COSTELLO M, LINNOILA Met al., 1987,

  ANTIDIABETIC EFFECT OF ELECTROSHOCK (ECS) IN OB/OB MICE

  , JOURNAL OF CLINICAL PHARMACOLOGY, Vol: 27, Pages: 716-716, ISSN: 0091-2700
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