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• Journal article
  Lynskey MT, Thurgur H, Athanasiou-Fragkouli A, Schlag AK, Nutt DJet al., 2024,

  Prescribed Medical Cannabis Use Among Older Individuals: Patient Characteristics and Improvements in Well-Being: Findings from T21

  , DRUGS & AGING, Vol: 41, Pages: 521-530, ISSN: 1170-229X
  • Cite
• Journal article
  Nutt D, Crome I, Young AH, 2024,

  Is it now time to prepare psychiatry for a psychedelic future?

  , BRITISH JOURNAL OF PSYCHIATRY, ISSN: 0007-1250
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• Journal article
  Copa D, Erritzoe D, Giribaldi B, Nutt D, Carhart-Harris R, Tagliazucchi Eet al., 2024,

  Predicting the outcome of psilocybin treatment for depression from baseline fMRI functional connectivity

  , JOURNAL OF AFFECTIVE DISORDERS, Vol: 353, Pages: 60-69, ISSN: 0165-0327
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• Journal article
  Peill J, Marguilho M, Erritzoe D, Barba T, Greenway KT, Rosas F, Timmermann C, Carhart-Harris Ret al., 2024,

  Psychedelics and the 'inner healer': Myth or mechanism?

  , JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 38, Pages: 417-424, ISSN: 0269-8811
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• Journal article
  Erritzoe D, Barba T, Spriggs MJ, Rosas FE, Nutt DJ, Carhart-Harris Ret al., 2024,

  Effects of discontinuation of serotonergic antidepressants prior to psilocybin therapy versus escitalopram for major depression

  , JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 38, Pages: 458-470, ISSN: 0269-8811
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• Journal article
  Schlag AK, Nutt DJ, Lynskey M, 2024,

  Using real world evidence to optimize care: the case of medical cannabis

  , EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH, Vol: 24, Pages: 463-465, ISSN: 1473-7167
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• Journal article
  Vohryzek J, Cabral J, Timmermann C, Atasoy S, Roseman L, Nutt DJ, Carhart-Harris RL, Deco G, Kringelbach MLet al., 2024,

  The flattening of spacetime hierarchy of the N,N-dimethyltryptamine brain state is characterized by harmonic decomposition of spacetime (HADES) framework

  , NATIONAL SCIENCE REVIEW, Vol: 11, ISSN: 2095-5138
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• Journal article
  Thurgur H, Lynskey M, Schlag AK, Croser C, Nutt DJ, Iveson Eet al., 2024,

  Feasibility of a cannabidiol-dominant cannabis-based medicinal product for the treatment of long COVID symptoms: A single-arm open-label feasibility trial

  , BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, Vol: 90, Pages: 1081-1093, ISSN: 0306-5251
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• Journal article
  Weiss B, Roseman L, Giribaldi B, Nutt DJ, Carhart-Harris RL, Erritzoe Det al., 2024,

  Unique Psychological Mechanisms Underlying Psilocybin Therapy Versus Escitalopram Treatment in the Treatment of Major Depressive Disorder

  , INTERNATIONAL JOURNAL OF MENTAL HEALTH AND ADDICTION, Vol: 22, Pages: 806-841, ISSN: 1557-1874
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• Journal article
  Luppi A, Rosas FE, Noonan MP, Mediano PAM, Kringelbach ML, Carhart-Harris RL, Stamatakis EA, Vernon AC, Turkheimer FEet al., 2024,

  Oxygen and the spark of human brain evolution: complex interactions of metabolism and cortical expansion across development and evolution

  , The Neuroscientist, Vol: 30, Pages: 173-198, ISSN: 1073-8584

  Scientific theories on the functioning and dysfunction of the human brain require an understanding of its development—before and after birth and through maturation to adulthood—and its evolution. Here we bring together several accounts of human brain evolution by focusing on the central role of oxygen and brain metabolism. We argue that evolutionary expansion of human transmodal association cortices exceeded the capacity of oxygen delivery by the vascular system, which led these brain tissues to rely on nonoxidative glycolysis for additional energy supply. We draw a link between the resulting lower oxygen tension and its effect on cytoarchitecture, which we posit as a key driver of genetic developmental programs for the human brain—favoring lower intracortical myelination and the presence of biosynthetic materials for synapse turnover. Across biological and temporal scales, this protracted capacity for neural plasticity sets the conditions for cognitive flexibility and ongoing learning, supporting complex group dynamics and intergenerational learning that in turn enabled improved nutrition to fuel the metabolic costs of further cortical expansion. Our proposed model delineates explicit mechanistic links among metabolism, molecular and cellular brain heterogeneity, and behavior, which may lead toward a clearer understanding of brain development and its disorders.

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