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• Journal article
  Martial C, Carhart-Harris R, Timmermann C, 2024,

  Within-subject comparison of near-death and psychedelic experiences: acute and enduring effects

  , NEUROSCIENCE OF CONSCIOUSNESS, Vol: 2024
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• Journal article
  Brouwer A, Carhart-Harris RL, Raison CL, 2024,

  Psychotomimetic compensation versus sensitization.

  , Pharmacol Res Perspect, Vol: 12

  It is a paradox that psychotomimetic drugs can relieve symptoms that increase risk of and cooccur with psychosis, such as attention and motivational deficits (e.g., amphetamines), pain (e.g., cannabis) and symptoms of depression (e.g., psychedelics, dissociatives). We introduce the ideas of psychotomimetic compensation and psychotomimetic sensitization to explain this paradox. Psychotomimetic compensation refers to a short-term stressor or drug-induced compensation against stress that is facilitated by engagement of neurotransmitter/modulator systems (endocannabinoid, serotonergic, glutamatergic and dopaminergic) that mediate the effects of common psychotomimetic drugs. Psychotomimetic sensitization occurs after repeated exposure to stress and/or drugs and is evidenced by the gradual intensification and increase of psychotic-like experiences over time. Theoretical and practical implications of this model are discussed.

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• Journal article
  Lynskey MT, Thurgur H, Athanasiou-Fragkouli A, Schlag AK, Nutt DJet al., 2024,

  Suicidal Ideation in Medicinal Cannabis Patients: A 12-Month Prospective Study

  , ARCHIVES OF SUICIDE RESEARCH, ISSN: 1381-1118
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• Journal article
  Luppi AI, Mediano PAM, Rosas FE, Allanson J, Pickard J, Carhart-Harris RL, Williams GB, Craig MM, Finoia P, Owen AM, Naci L, Menon DK, Bor D, Stamatakis EAet al., 2024,

  A synergistic workspace for human consciousness revealed by Integrated Information Decomposition

  , eLife, Vol: 12

  <jats:p>How is the information-processing architecture of the human brain organised, and how does its organisation support consciousness? Here, we combine network science and a rigorous information-theoretic notion of synergy to delineate a ‘synergistic global workspace’, comprising gateway regions that gather synergistic information from specialised modules across the human brain. This information is then integrated within the workspace and widely distributed via broadcaster regions. Through functional MRI analysis, we show that gateway regions of the synergistic workspace correspond to the human brain’s default mode network, whereas broadcasters coincide with the executive control network. We find that loss of consciousness due to general anaesthesia or disorders of consciousness corresponds to diminished ability of the synergistic workspace to integrate information, which is restored upon recovery. Thus, loss of consciousness coincides with a breakdown of information integration within the synergistic workspace of the human brain. This work contributes to conceptual and empirical reconciliation between two prominent scientific theories of consciousness, the Global Neuronal Workspace and Integrated Information Theory, while also advancing our understanding of how the human brain supports consciousness through the synergistic integration of information.</jats:p>

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• Journal article
  Siegel JS, Subramanian S, Perry D, Kay BP, Gordon EM, Laumann TO, Reneau TR, Metcalf NV, Chacko RV, Gratton C, Horan C, Krimmel SR, Shimony JS, Schweiger JA, Wong DF, Bender DA, Scheidter KM, Whiting FI, Padawer-Curry JA, Shinohara RT, Chen Y, Moser J, Yacoub E, Nelson SM, Vizioli L, Fair DA, Lenze EJ, Carhart-Harris R, Raison CL, Raichle ME, Snyder AZ, Nicol GE, Dosenbach NUFet al., 2024,

  Psilocybin desynchronizes the human brain

  , NATURE, ISSN: 0028-0836
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• Journal article
  de la Salle S, Kettner H, Levesque JT, Garel N, Dames S, Patchett-Marble R, Rej S, Gloeckler S, Erritzoe D, Carhart-Harris R, Greenway KTet al., 2024,

  Longitudinal experiences of Canadians receiving compassionate access to psilocybin-assisted psychotherapy

  , SCIENTIFIC REPORTS, Vol: 14, ISSN: 2045-2322
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• Journal article
  Roseman L, Erritzoe D, Nutt D, Carhart-Harris R, Timmermann Cet al., 2024,

  Interrupting the Psychedelic Experience Through Contextual Manipulation to Study Experience Efficacy

  , JAMA NETWORK OPEN, Vol: 7, ISSN: 2574-3805
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• Journal article
  Thurgur H, Lynskey M, Schlag AK, Croser C, Nutt DJ, Iveson Eet al., 2024,

  Authors' response to letter 'On the use of open-label studies for the evaluation of cannabis-based products for the treatment of long-COVID'

  , BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, ISSN: 0306-5251
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• Journal article
  Luppi AI, Mediano PAM, Rosas FE, Allanson J, Pickard J, Carhart-Harris RL, Williams GB, Craig MM, Finoia P, Owen AM, Naci L, Menon DK, Bor D, Stamatakis EAet al., 2024,

  A synergistic workspace for human consciousness revealed by integrated information decomposition

  , eLife, Vol: 12, ISSN: 2050-084X

  How is the information-processing architecture of the human brain organised, and how does its organisation support consciousness? Here, we combine network science and a rigorous information-theoretic notion of synergy to delineate a ‘synergistic global workspace’, comprising gateway regions that gather synergistic information from specialised modules across the human brain. This information is then integrated within the workspace and widely distributed via broadcaster regions. Through functional MRI analysis, we show that gateway regions of the synergistic workspace correspond to the human brain’s default mode network, whereas broadcasters coincide with the executive control network. We find that loss of consciousness due to general anaesthesia or disorders of consciousness corresponds to diminished ability of the synergistic workspace to integrate information, which is restored upon recovery. Thus, loss of consciousness coincides with a breakdown of information integration within the synergistic workspace of the human brain. This work contributes to conceptual and empirical reconciliation between two prominent scientific theories of consciousness, the Global Neuronal Workspace and Integrated Information Theory, while also advancing our understanding of how the human brain supports consciousness through the synergistic integration of information.

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• Journal article
  Pasculli G, Busan P, Jackson ES, Alm PA, De Gregorio D, Maguire GA, Goodwin GM, Gobbi G, Erritzoe D, Carhart-Harris RLet al., 2024,

  Psychedelics in developmental stuttering to modulate brain functioning: a new therapeutic perspective?

  , FRONTIERS IN HUMAN NEUROSCIENCE, Vol: 18, ISSN: 1662-5161
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