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Journal articlePellegrini L, Fineberg NA, O'Connor S, et al., 2025,
Single-dose (10 mg) psilocybin reduces symptoms in adults with obsessive-compulsive disorder: A pharmacological challenge study
, COMPREHENSIVE PSYCHIATRY, Vol: 142, ISSN: 0010-440X -
Journal articleMediano P, Rosas FE, Luppi AI, et al., 2025,
Towards a unified taxonomy of information dynamics via Integrated Information Decomposition
, Proceedings of the National Academy of Sciences of USA, Vol: 122, ISSN: 0027-8424Our ability to understand and control complex systems of many interacting parts remains limited. A key challenge is that we still don’t know how best to describe – and quantify – the many-to-many dynamical interactions that characterise their complexity. To address this limitation, we introduce the mathematical framework of Integrated Information Decomposition, or ΦID. ΦID provides a comprehensive framework to disentangle and characterise the information dynamics of complex multivariate systems. On the theoretical side, ΦID reveals the existence of previously unreported modes of collective information flow, providing tools to express well-known measures of information transfer, information storage, and dynamicalcomplexity as aggregates of these modes, thereby overcoming some of their known theoretical shortcomings. On the empirical side, we validate our theoretical results with computational models and examples from over 1,000 biological, social, physical, and synthetic dynamicalsystems. Altogether, ΦID improves our understanding of the behaviour of widely-used measures for characterising complex systems across disciplines, and leads to new more refined analyses of dynamical complexity.
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Journal articlePalmisano VF, Agnorelli C, Faraji S, et al., 2025,
Computational design of an improved photoswitchable psychedelic based on light absorption, membrane permeation and protein binding
, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, Vol: 27, Pages: 19454-19464, ISSN: 1463-9076 -
Journal articleNutt D, 2025,
How to put psychiatrists back at the centre of medicine's innovation
, BRITISH JOURNAL OF PSYCHIATRY, ISSN: 0007-1250 -
Journal articleVohryzek J, Luppi AI, Atasoy S, et al., 2025,
N,N-dimethyltryptamine effects on connectome harmonics, subjective experience and comparative psychedelic experiences
, NEUROPSYCHOPHARMACOLOGY, ISSN: 0893-133X- Cite
- Citations: 1
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Journal articleNutt DJ, Erritzoe D, Schlag A, et al., 2025,
A lexicon for psychedelic research and treatment
, Drug Science, Policy and Law, Vol: 11, ISSN: 2050-3245<jats:p>Psychedelics are undergoing a clinical research renaissance, with compounds such as psilocybin advancing to Phase 3 trials for treatment-resistant depression and receiving fast-track or breakthrough designations from regulatory agencies. Despite this progress, the field lacks standardized terminology to guide clinical development, dosing, safety monitoring, and regulatory classification. Here, we present a comprehensive framework for psychedelic nomenclature based on pharmacology, subjective effects, dosing, and therapeutic use. A pharmacological classification system is described, encompassing serotonergic, glutamatergic, kappaergic, GABAergic, and atypical psychedelics. Dose-dependent categories—microdose, minidose, mididose, and macrodose—are introduced to standardize the description of dosing levels and intended subjective effects. We also standardize vague terms like “short-acting” or “long-acting” with specific pharmacokinetic parameters, including route, onset, and duration of action. Safety considerations are also explored, particularly cardiovascular and psychological effects, and we discuss the need for risk mitigation protocols in higher-risk compounds like ibogaine. The evolving role of psychotherapy in psychedelic treatment is also examined, proposing terminology to distinguish between “psychedelic therapy” and varying levels of psychological support. A three-phase treatment model—preparation, dosing, and integration—is recommended as a minimum standard for safe and effective care. The lack of comparative research on psychotherapy modalities in psychedelic therapy is identified as a critical gap. Ultimately, a standardized lexicon and clinical framework will support clearer communication, improved trial design, and more equitable access as psychedelic therapies move toward widespread clinical use.</jats:p>
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Journal articleGodfrey K, Douglass H, Erritzoe D, et al., 2025,
The role of GABA, glutamate, and Glx levels in treatment of major depressive disorder: A systematic review and meta-analysis
, PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, Vol: 141, ISSN: 0278-5846 -
Journal articleAngyus M, Osborn S, Haijen E, et al., 2025,
Validation of the Imperial Psychedelic Predictor Scale (vol 54, pg 3539, 2024)
, PSYCHOLOGICAL MEDICINE, Vol: 55, ISSN: 0033-2917 -
Journal articlePurple RJ, Gupta R, Thomas CW, et al., 2025,
Short- and long-term modulation of rat prefrontal cortical activity following single doses of psilocybin
, MOLECULAR PSYCHIATRY, ISSN: 1359-4184- Cite
- Citations: 1
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Journal articleRosas De Andraca FE, Gutknecht A, Mediano P, et al., 2025,
Characterising high-order interdependence via entropic conjugation
, Communications Physics, Vol: 8, ISSN: 2399-3650High-order phenomena are pervasive across complex systems, yet their formal characterisation remains a formidable challenge. The literature provides various information-theoretic quantities that capture high-order interdependencies, but their conceptual foundations and mutual relationships are not well understood. The lack of unifying principles underpinning these quantities impedes a principled selection of appropriate analytical tools for guiding applications. Here we introduce entropic conjugation as a formal principle to investigate the space of possible high-order measures, which clarifies the nature of the existent high-order measures while revealing gaps in the literature. Additionally, entropic conjugation leads to notions of symmetry and skew-symmetry which serve as key indicators ensuring a balanced account of high-order interdependencies. Our analyses highlight the O-information as the unique skew-symmetric measure whose estimation cost scales linearly with system size, which spontaneously emerges as a natural axis of variation among high-order quantities in real-world and simulated systems.
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