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• Journal article
  Agnorelli C, Spriggs M, Godfrey K, Sawicka G, Bohl B, Douglass H, Fagiolini A, Parastoo H, Carhart-Harris R, Nutt D, Erritzoe Det al., 2025,

  Neuroplasticity and psychedelics: a comprehensive examination of classic and non-classic compounds in pre and clinical models

  , Neuroscience and Biobehavioral Reviews, Vol: 172, ISSN: 0149-7634

  Neuroplasticity, the ability of the nervous system to adapt throughout an organism's lifespan, offers potential as both a biomarker and treatment target for neuropsychiatric conditions. Psychedelics, a burgeoning category of drugs, are increasingly prominent in psychiatric research, prompting inquiries into their mechanisms of action. Distinguishing themselves from traditional medications, psychedelics demonstrate rapid and enduring therapeutic effects after a single or few administrations, believed to stem from their neuroplasticity-enhancing properties. This review examines how classic psychedelics (e.g., LSD, psilocybin, N,N-DMT) and non-classic psychedelics (e.g., ketamine, MDMA) influence neuroplasticity. Drawing from preclinical and clinical studies, we explore the molecular, structural, and functional changes triggered by these agents. Animal studies suggest psychedelics induce heightened sensitivity of the nervous system to environmental stimuli (meta-plasticity), re-opening developmental windows for long-term structural changes (hyper-plasticity), with implications for mood and behavior. Translating these findings to humans faces challenges due to limitations in current imaging techniques. Nonetheless, promising new directions for human research are emerging, including the employment of novel positron-emission tomography (PET) radioligands, non-invasive brain stimulation methods, and multimodal approaches. By elucidating the interplay between psychedelics and neuroplasticity, this review informs the development of targeted interventions for neuropsychiatric disorders and advances understanding of psychedelics' therapeutic potential.

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• Journal article
  Cardone P, Alnagger NLN, Martial C, van der Lande GJM, Sandell R, Carhart-Harris R, Gosseries Oet al., 2025,

  Psilocybin for disorders of consciousness: A case-report study

  , CLINICAL NEUROPHYSIOLOGY, Vol: 173, Pages: 181-189, ISSN: 1388-2457
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  • Citations: 2
• Journal article
  Timmermann Slater CB, Sanders J, Reydellet D, Barba T, Luan L, Soto Angona O, Ona G, Allocca G, Smith C, Daily Z, Mason N, Kloft-Heller L, Kuchar M, Janeckova L, Palenicek T, Erritzoe D, Ramaekers J, Carhart-Harris R, Uthaug Met al., 2025,

  Exploring 5-MeO-DMT as a pharmacological model for deconstructed consciousness

  , Neuroscience of Consciousness, Vol: 2025, ISSN: 2057-2107

  5-MeO-DMT is a short-acting psychedelic that is anecdotally reported to induce a radical disruption of the self and a paradoxical quality of aroused, waking awareness that is nevertheless devoid of any specific perceptual contents. Here, we conducted an exploratory observational study of the phenomenological and neuronal effects of this compound. We collected micro-phenomenological interviews, psychometric questionnaires, and electroencephalography (EEG) in naturalistic ceremonial settings where 5-MeO-DMT was ingested. Results revealed that the 5-MeO-DMT experience followed a dynamic progression that—only in the most extreme cases—manifested as a complete absence of self-experience and other phenomenal content with preserved awareness. Furthermore, visual imagery, bodily self-disruption, narrative self-disruption, and reduced phenomenal distinctions occurred in a variable fashion. EEG analyses revealed the 5-MeO-DMT experience was characterised by (global) alpha and (posterior) beta power reductions, implying a mode of brain functioning where top-down models are inhibited. Our preliminary phenomenological findings confirm the potential utility of 5-MeO-DMT as a pharmacological model for deconstructed consciousness while noting the limitations of employing retrospective questionnaires for this purpose. Considering the exploratory nature of this study and its limitations inherent to its naturalistic nature, further research employing real-time experience sampling and phenomenologically trained participants in controlled environments could expand our findings to meaningfully inform the potential of this tool for the scientific study of consciousness.

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• Journal article
  Singleton SP, Timmermann C, Luppi AI, Eckernas E, Roseman L, Carhart-Harris RL, Kuceyeski Aet al., 2025,

  Network control energy reductions under DMT relate to serotonin receptors, signal diversity, and subjective experience

  , COMMUNICATIONS BIOLOGY, Vol: 8
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• Journal article
  Pasquini L, Simon AJ, Gallen CL, Kettner H, Roseman L, Gazzaley A, Carhart-Harris RL, Timmermann Cet al., 2025,

  Dynamic medial parietal and hippocampal deactivations under DMT relate to sympathetic output and altered sense of time, space, and the self

  , IMAGING NEUROSCIENCE, Vol: 3
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  • Citations: 1
• Journal article
  Havenith MN, Leidenberger M, Brasanac J, Corvacho M, Carmo Figueiredo I, Schwarz L, Uthaug M, Rakusa S, Bernardic M, Vasquez-Mock L, Perez Rosal S, Carhart-Harris R, Gold SM, Jungaberle H, Jungaberle Aet al., 2025,

  Decreased CO₂ saturation during circular breathwork supports emergence of altered states of consciousness

  , COMMUNICATIONS PSYCHOLOGY, Vol: 3
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  • Citations: 8
• Journal article
  Coleman CR, Shinozuka K, Tromm R, Dipasquale O, Kaelen M, Roseman L, Muthukumaraswamy S, Nutt DJ, Barnett L, Carhart-Harris Ret al., 2025,

  The Role of the Dorsolateral Prefrontal Cortex in Ego Dissolution and Emotional Arousal During the Psychedelic State

  , HUMAN BRAIN MAPPING, Vol: 46, ISSN: 1065-9471
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• Journal article
  Zhou K, de Wied D, Carhart-Harris RL, Kettner Het al., 2025,

  Prediction of hallucinogen persisting perception disorder and thought disturbance symptoms following psychedelic use

  , PNAS NEXUS, Vol: 4
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  • Citations: 2
• Journal article
  Roseman L, 2025,

  A reflection on paradigmatic tensions within the FDA advisory committee for MDMA-assisted therapy

  , JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 39, Pages: 313-315, ISSN: 0269-8811
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  • Citations: 1
• Journal article
  Piccinini JI, Perl YS, Pallavicini C, Deco G, Kringelbach M, Nutt D, Carhart-Harris R, Timmermann C, Tagliazucchi Eet al., 2025,

  Transient destabilization of whole brain dynamics induced by N,N-Dimethyltryptamine (DMT)

  , COMMUNICATIONS BIOLOGY, Vol: 8
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