Testing a participant of a dementia study at Imperial College London's School of Public Health

What type of studies are being conducted?

Studies may vary from simple questionnaires to clinical trials investigating new preventative treatments. Those on the register will be given full details of each study and will have time to consider whether they would like to get involved. You are under no obligation to take part in any study just because you have agreed to be on the register.

Current Studies

CHARIOT COVID-19 Rapid Response study (CCRR)

A collaborative initiative run from Imperial College London between groups within the School of Public Health and the National Heart and Lung Institute. A key objective of this study is to examine, and track over time, the age-group specific prevalence of past symptomatic COVID-19 infection and incidence (new cases) of symptomatic COVID-19 infection in older adults (50+ years) in London and the surrounding area. This will enable the ‘real-time’ monitoring of the pandemic in a small geographical area, linking self-reported community disease surveillance (proxy for mild to moderate disease) with laboratory-confirmed disease surveillance (proxy for disease requiring hospitalisation).

Secondly, we aim to measure the impact of the COVID-19 epidemic and preventive measures (social isolation/distancing) on the mental and physical well-being of the population. We hope these findings will Identify lifestyle, biomedical and psychosocial factors that determine vulnerability and resilience to COVID-19 infection.

The study has invited ~40,000 CHARIOT register participants, to complete an online questionnaire weekly for up to a year. The Register participants may also refer members of their household to participate, provided they are aged 18+. The weekly questionnaire will contain questions surround COVID-19 symptomology and exposure risks. Participants will also be asked questions surrounding their health behaviour and wellbeing 6-weekly.

 

CHARIOT:PRO Substudy 2

Participants that were excluded from the CHARIOT: PRO Substudy in a randomised process are being invited to attend a one-off visit at the Research Hub at Charing Cross Hospital. They will complete further testing and samples.

 

This study is no longer seeking new volunteers.

 

Volunteers who have consented to join the CHARIOT register are invited to participate in our research studies.

Please visit our Get involved page to find out more.

 

 

The CHARIOT: PRO Substudy

An observational study examining changes in cognition over time, and how we can best identify these at an early stage. Involves a medical health check, physical and neurological examinations and cognitive assessments.

 

Volunteers who have consented to join the CHARIOT register are invited to participate in our research studies.

Please visit our Get involved page to find out more.

Previous research studies

CHARIOT: PRO Main Study

An observational study examining changes in cognition over time, and how we can best identify these at an early stage. Involves medical health check, physical and neurological examinations and cognitive assessments.

Generation 1 and 2

The Generation study was sponsored by Novartis and Amgen as part of the Alzheimer’s prevention initiative. An anti-amyloid drug was being assessed for safety and efficacy in the prevention or delay of the onset of Alzheimer's in people at risk for developing symptoms based on their age and genetic status. This study was discontinued across all sites worldwide on 11th July due to safety concerns. The AGE Research Unit screened many volunteers for inclusion in the trial; however, only a small number were actually started on treatment. Thus, we are pleased that not many of our participants were exposed to potential risks to their safety. People who were on treatment are being followed up for 6 months to provide information on their health and cognitive status.

Press Release

Previous Studies

Neurovision

This study involves research into changes in the eye that might accompany the early development of Alzheimer’s Disease. We use an experimental imaging technique to highlight plaques in the back of the eye.  

The UK Prescreening Study

A study to assess memory function in individuals who feel they have noticed recent changes in their memory and to identify people interested in being involved in preventative trials.

Previous Studies

TOMMORROW

An international clinical trial to determine whether a genetic biomarker can predict an individual’s risk of developing memory problems and determine whether a specific treatment would help delay the onset of memory problems in people who are at high risk.

MULTIMODE Study

Volunteers who have consented to join the CHARIOT register are invited to participate in our research studies.

Please visit our Get involved page to find out more.