Research
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Synthetic Biology underpins advances in the bioeconomy
Biological systems - including the simplest cells - exhibit a broad range of functions to thrive in their environment. Research in the Imperial College Centre for Synthetic Biology is focused on the possibility of engineering the underlying biochemical processes to solve many of the challenges facing society, from healthcare to sustainable energy. In particular, we model, analyse, design and build biological and biochemical systems in living cells and/or in cell extracts, both exploring and enhancing the engineering potential of biology.
As part of our research we develop novel methods to accelerate the celebrated Design-Build-Test-Learn synthetic biology cycle. As such research in the Centre for Synthetic Biology highly multi- and interdisciplinary covering computational modelling and machine learning approaches; automated platform development and genetic circuit engineering ; multi-cellular and multi-organismal interactions, including gene drive and genome engineering; metabolic engineering; in vitro/cell-free synthetic biology; engineered phages and directed evolution; and biomimetics, biomaterials and biological engineering.
Publications
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Journal articleBatty EC, Jensen K, Freemont PS, 2012,
PML NUCLEAR BODIES AND OTHER TRIM-DEFINED SUBCELLULAR COMPARTMENTS
, TRIM/RBCC PROTEINS, Vol: 770, Pages: 39-58, ISSN: 0065-2598- Author Web Link
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- Citations: 6
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Journal articlePan W, Yuan Y, Goncalves J, et al., 2012,
Reconstruction of Arbitrary Biochemical Reaction Networks: A Compressive Sensing Approach
, 2012 IEEE 51ST ANNUAL CONFERENCE ON DECISION AND CONTROL (CDC), Pages: 2334-2339, ISSN: 0743-1546- Author Web Link
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- Citations: 20
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Journal articleOyarzĂșn DA, Stan GB, 2012,
Synthetic gene circuits for metabolic control: design tradeoffs and constraints
, Journal of the Royal Society Interface, Vol: 10 -
Journal articleLossi NS, Dajani R, Freemont P, et al., 2011,
Structure-function analysis of HsiF, a gp25-like component of the type VI secretion system, in Pseudomonas aeruginosa
, MICROBIOLOGY-SGM, Vol: 157, Pages: 3292-3305, ISSN: 1350-0872- Author Web Link
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- Citations: 38
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Journal articleZhang H-T, Chen MZQ, Stan G-B, 2011,
Fast Consensus Via Predictive Pinning Control
, IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS I-REGULAR PAPERS, Vol: 58, Pages: 2247-2258, ISSN: 1549-8328- Author Web Link
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- Citations: 97
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Journal articleDalchau N, Baek SJ, Briggs HM, et al., 2011,
The circadian oscillator gene GIGANTEA mediates a long-term response of the Arabidopsis thaliana circadian clock to sucrose
, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 108, Pages: 5104-5109, ISSN: 0027-8424- Author Web Link
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- Citations: 171
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Journal articlePeccoud J, Anderson JC, Chandran D, et al., 2011,
Essential information for synthetic DNA sequences
, NATURE BIOTECHNOLOGY, Vol: 29, Pages: 22-22, ISSN: 1087-0156- Author Web Link
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- Citations: 33
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Journal articleMacDonald JT, Barnes C, Kitney RI, et al., 2011,
Computational design approaches and tools for synthetic biology
, INTEGRATIVE BIOLOGY, Vol: 3, Pages: 97-108, ISSN: 1757-9694- Author Web Link
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- Citations: 57
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Journal articleYuan Y, Stan G-B, Warnick S, et al., 2011,
Robust dynamical network structure reconstruction.
, Automatica, Vol: 47, Pages: 1230-1235 -
Journal articleDalchau N, Hubbard KE, Robertson FC, et al., 2010,
Correct biological timing in Arabidopsis requires multiple light-signaling pathways
, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 107, Pages: 13171-13176, ISSN: 0027-8424- Author Web Link
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- Citations: 50
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Journal articleMhawej M-J, Brunet-Francois C, Fonteneau R, et al., 2009,
Apoptosis characterizes immunological failure of HIV infected patients
, CONTROL ENGINEERING PRACTICE, Vol: 17, Pages: 798-804, ISSN: 0967-0661- Author Web Link
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- Citations: 8
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Journal articleStan G-B, Belmudes F, Fonteneau R, et al., 2008,
Modelling the influence of activation-induced apoptosis of CD4(+) and CD8(+) T-cells on the immune system response of a HIV-infected patient
, IET SYSTEMS BIOLOGY, Vol: 2, Pages: 94-102, ISSN: 1751-8849- Author Web Link
- Open Access Link
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- Citations: 13
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Journal articleZhang H-T, Chen MZ, Stan G-B, et al., 2008,
Collective Behavior Coordination with Predictive Mechanisms
, IEEE CIRCUITS AND SYSTEMS MAGAZINE, Vol: 8, Pages: 67-85, ISSN: 1531-636X- Author Web Link
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- Citations: 67
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Journal articleZhang H-T, Chen MZ, Zhou T, et al., 2008,
Ultrafast consensus via predictive mechanisms
, EPL, Vol: 83, ISSN: 0295-5075- Author Web Link
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- Citations: 37
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Journal articleStan G-B, Sepulchre R, 2007,
Analysis of interconnected oscillators by dissipativity theory
, IEEE TRANSACTIONS ON AUTOMATIC CONTROL, Vol: 52, Pages: 256-270, ISSN: 0018-9286- Author Web Link
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- Citations: 203
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Journal articleSepulchre R, Stan GB, 2005,
Feedback mechanisms for global oscillations in Lure systems
, SYSTEMS & CONTROL LETTERS, Vol: 54, Pages: 809-818, ISSN: 0167-6911- Author Web Link
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- Citations: 18
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Journal articleStan GB, Embrechts JJ, Archambeau D, 2002,
Comparison of different impulse response measurement techniques
, JOURNAL OF THE AUDIO ENGINEERING SOCIETY, Vol: 50, Pages: 249-262, ISSN: 0004-7554- Author Web Link
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- Citations: 137
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Journal articleEmbrechts JJ, Archambeau D, Stan GB, 2001,
Determination of the scattering coefficient of random rough diffusing surfaces for room acoustics applications
, ACUSTICA, Vol: 87, Pages: 482-494, ISSN: 0001-7884- Author Web Link
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- Citations: 13
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