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BibTex format

author = {Nickel, S and Serwa, RA and Kaschani, F and Ninck, S and Zweerink, S and Tate, EW and Kaiser, M},
doi = {10.1002/chem.201500934},
journal = {Chemistry-A European Journal},
pages = {10721--10728},
title = {Chemoproteomic Evaluation of the Polyacetylene Callyspongynic Acid},
url = {},
volume = {21},
year = {2015}

RIS format (EndNote, RefMan)

AB - Polyacetylenes are a class of alkyne-containing natural products. Although potent bioactivities and thus possible applications as chemical probes have already been reported for some polyacetylenes, insights into the biological activities or molecular mode of action are still rather limited in most cases. To overcome this limitation, we describe the application of the polyacetylene callyspongynic acid in the development of an experimental roadmap for characterizing potential protein targets of alkyne-containing natural products. To this end, we undertook the first chemical synthesis of callyspongynic acid. We then used in situ chemical proteomics methods to demonstrate extensive callyspongynic acid-mediated chemical tagging of endoplasmic reticulum-associated lipid-metabolizing and modifying enzymes. We anticipate that an elucidation of protein targets of natural products may serve as an effective guide to the development of subsequent biological assays that aim to identify chemical phenotypes and bioactivities.
AU - Nickel,S
AU - Serwa,RA
AU - Kaschani,F
AU - Ninck,S
AU - Zweerink,S
AU - Tate,EW
AU - Kaiser,M
DO - 10.1002/chem.201500934
EP - 10728
PY - 2015///
SN - 1521-3765
SP - 10721
TI - Chemoproteomic Evaluation of the Polyacetylene Callyspongynic Acid
T2 - Chemistry-A European Journal
UR -
UR -
VL - 21
ER -