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  • Journal article
    Pearce FA, Lim SH, Bythell M, Lanyon P, Hogg R, Taylor A, Powter G, Cooke GS, Ward H, Chilcot J, Thomas H, Mumford L, McAdoo SP, Pettigrew GJ, Lightstone L, Willicombe Met al., 2023,

    Antibody prevalence after three or more COVID-19 vaccine doses in individuals who are immunosuppressed in the UK: a cross-sectional study from MELODY

    , The Lancet Rheumatology, Vol: 5, Pages: e461-e473, ISSN: 2665-9913

    BackgroundIn the UK, additional COVID-19 vaccine booster doses and treatments are offered to people who are immunosuppressed to protect against severe COVID-19, but how best to choose the individuals that receive these vaccine booster doses and treatments is unclear. We investigated the association between seropositivity to SARS-CoV-2 spike protein with demographic, disease, and treatment-related characteristics after at least three COVID-19 vaccines in three cohorts of people who are immunosuppressed.MethodsIn a cross-sectional study using UK national disease registries, we identified, contacted, and recruited recipients of solid organ transplants, participants with rare autoimmune rheumatic diseases, and participants with lymphoid malignancies who were 18 years or older, resident in the UK, and who had received at least three doses of a COVID-19 vaccine. The study was open to recruitment from Dec 7, 2021, to June 26, 2022. Participants received a lateral flow immunoassay test for SARS-CoV-2 spike antibodies to complete at home, and an online questionnaire. Multivariable logistic regression was used to estimate the mutually adjusted odds of seropositivity against each characteristic.FindingsBetween Feb 14 and June 26, 2022, we screened 101 972 people (98 725 invited, 3247 self-enrolled) and recruited 28 411 (27·9%) to the study. 23 036 (81·1%) recruited individuals provided serological data. Of these, 9927 (43·1%) were recipients of solid organ transplants, 6516 (28·3%) had rare autoimmune rheumatic diseases, and 6593 (28·6%) had lymphoid malignancies. 10 485 (45·5%) participants were men and 12 535 (54·4%) were women (gender was not reported for 16 [<0·1%] participants), and 21661 (94·0%) participants were of White ethnicity. The median age of participants with solid organ transplants was 60 years (SD 50–67), with rare autoimmune rheumatic diseases was

  • Journal article
    Smith RM, Jones RB, Specks U, Bond S, Nodale M, Al-jayyousi R, Andrews J, Bruchfeld A, Camilleri B, Carette S, Cheung CK, Derebail V, Doulton T, Ferraro A, Forbess L, Fujimoto S, Furuta S, Gewurz-Singer O, Harper L, Ito-Ihara T, Khalidi N, Klocke R, Koening C, Komagata Y, Langford C, Lanyon P, Luqmani R, McAlear C, Moreland LW, Mynard K, Nachman P, Pagnoux C, Peh CA, Pusey C, Ranganathan D, Rhee RL, Spiera R, Sreih AG, Tesar V, Walters G, Wroe C, Jayne D, Merkel PAet al., 2023,

    Rituximab versus azathioprine for maintenance of remission for patients with ANCA-associated vasculitis and relapsing disease: an international randomised controlled trial

    , ANNALS OF THE RHEUMATIC DISEASES, Vol: 82, Pages: 937-944, ISSN: 0003-4967
  • Journal article
    Lee PY, Davidson BA, Abraham RS, Alter B, Arostegui JI, Bell K, Belot A, Bergerson JRE, Bernard TJ, Brogan PA, Berkun Y, Deuitch NT, Dimitrova D, Georgin-Lavialle SA, Gattorno M, Grimbacher B, Hashem H, Hershfield MS, Ichord RN, Izawa K, Kanakry JA, Khubchandani RP, Klouwer FCC, Luton EA, Man AW, Meyts I, Van Montfrans JM, Ozen S, Saarela J, Santo GC, Sharma A, Soldatos A, Sparks R, Torgerson TR, Uriarte IL, Youngstein TAB, Zhou Q, Aksentijevich I, Kastner DL, Chambers EP, Ombrello AKet al., 2023,

    Evaluation and Management of Deficiency of Adenosine Deaminase 2 An International Consensus Statement

    , JAMA NETWORK OPEN, Vol: 6, ISSN: 2574-3805
  • Journal article
    Taylor E, Tona F, Singh-Curry V, Venter M, Carulli M, Tench C, Youngstein T, Dixon Let al., 2023,

    DWI scalp dot sign: superficial temporal artery restricted diffusion in giant cell arteritis

    , RHEUMATOLOGY, Vol: 62, Pages: E119-E121, ISSN: 1462-0324
  • Journal article
    Youngstein T, Haskard D, 2023,

    Obituary: Professor Justin Charles Mason

    , RHEUMATOLOGY, Vol: 62, Pages: 1716-1717, ISSN: 1462-0324
  • Journal article
    Nazarzadeh M, Bidel Z, Mohseni H, Canoy D, Pinho-Gomes A-C, Hassaine A, Dehghan A, Tregouet D-A, Smith NL, Rahimi Ket al., 2023,

    Blood pressure and risk of venous thromboembolism: a cohort analysis of 5.5 million UK adults and Mendelian randomization studies

    , Cardiovascular Research, Vol: 119, Pages: 835-842, ISSN: 0008-6363

    AimsEvidence for the effect of elevated blood pressure (BP) on the risk of venous thromboembolism (VTE) has been conflicting. We sought to assess the association between systolic BP and the risk of VTE.Methods and resultsThree complementary studies comprising an observational cohort analysis, a one-sample and two-sample Mendelian randomization were conducted using data from 5 588 280 patients registered in the Clinical Practice Research Datalink (CPRD) dataset and 432 173 UK Biobank participants with valid genetic data. Summary statistics of International Network on Venous Thrombosis genome-wide association meta-analysis was used for two-sample Mendelian randomization. The primary outcome was the first occurrence of VTE event, identified from hospital discharge reports, death registers, and/or primary care records. In the CPRD cohort, 104 017(1.9%) patients had a first diagnosis of VTE during the 9.6-year follow-up. Each 20 mmHg increase in systolic BP was associated with a 7% lower risk of VTE [hazard ratio: 0.93, 95% confidence interval (CI): (0.92–0.94)]. Statistically significant interactions were found for sex and body mass index, but not for age and subtype of VTE (pulmonary embolism and deep venous thrombosis). Mendelian randomization studies provided strong evidence for the association between systolic BP and VTE, both in the one-sample [odds ratio (OR): 0.69, (95% CI: 0.57–0.83)] and two-sample analyses [OR: 0.80, 95% CI: (0.70–0.92)].ConclusionWe found an increased risk of VTE with lower BP, and this association was independently confirmed in two Mendelian randomization analyses. The benefits of BP reduction are likely to outweigh the harms in most patient groups, but in people with predisposing factors for VTE, further BP reduction should be made cautiously.

  • Conference paper
    Dib M-J, Meena D, Zagkos L, Dipender G, Elliott P, Dehghan A, Tzoulaki Iet al., 2023,

    Sex-Specific Genetic Interrogation of Cardiovascular Disease Drug Targets

    , American Heart Association's Epidemiology and Prevention/Lifestyle and Cardiometabolic Health Scientific Sessions, Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0009-7322
  • Conference paper
    Meena D, Huang J, Dehghan A, Tzoulaki Iet al., 2023,

    Age at Menarche, Adulthood Body Mass Index and Risk of Subclinical Atherosclerosis: A Mendelian Randomization Study

    , American Heart Association's Epidemiology and Prevention/Lifestyle and Cardiometabolic Health Scientific Sessions, Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0009-7322
  • Journal article
    Dixon L, Colquhoun M, Taylor E, Carlucci F, Limback-stanic C, Singh-Curry V, tona F, Youngstein Tet al., 2023,

    Orbital giant cell arteritis: two cases of bilateral orbital inflammation and arterial diffusion restriction on MRI

    , Journal of Neurology, Vol: 270, Pages: 2793-2797, ISSN: 0340-5354
  • Journal article
    Dhaun N, Pugh D, Youngstein T, 2023,

    Percutaneous Intervention in Takayasu Arteritis Potential Advantages of Procedural Perseverance

    , JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 81, Pages: 65-67, ISSN: 0735-1097

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