Project title: Epigenomic profiling of human microglial transcription factors to elucidate Alzheimer’s disease pathogenesis
Supervisors: Dr Nathan Skene, Dr Alexi Nott
Location: Level 7, Sir Michael Uren Hub, White City Campus, 86 Wood Lane, W12 0BZ
About me
My educational journey in the sciences began with a BSc in Genomics at the University of Bologna, followed by a MSc in Genomic Medicine at Imperial College London. During my MSc project in the Skene Lab, I worked on developing Targeted Insertion of Promoters Sequencing (TIP-seq), a method for epigenomic profiling, which led to my decision to continue as a PhD student in the same group.
I am now in the third year of my PhD, focusing on microglia, the resident immune cells of the brain, in the context of Alzheimer’s disease (AD). My current work centres on developing and optimising a protocol to sort microglial nuclei from post-mortem human cortex and validating this approach using single-cell RNA sequencing. The aim is to use this optimised protocol to profile microglia-specific transcription factors in enriched microglial populations and integrate these data with AD GWAS findings.
Outside of the lab, I enjoy sports, spending time with family and friends, and travelling to explore new places and perspectives.
Conferences
Poster presenter at the UK DRI Connectome 2024
Poster presenter at CURE-ND in Bonn (2024) and Paris (2025)
Qualifications
- 2022-2023: MSc Genomic Medicine, Imperial College London
- 2019-2022: BSc Genomics, University of Bologna
Contact details
Email: isidora.gocmanac22@imperial.ac.uk
LinkedIn: isidora-gocmanac-16b36124b
