Marianna Papageorgopoulou
Project title: Multi-omic Characterisation of the Molecular Neuropathology of ABCA7 Variants in Alzheimer’s Disease
Supervisor: Professor Paul Matthews, Dr Johanna Jackson, Dr David Owen
Location: Level 7, Sir Michael Uren Hub, White City Campus, 86 Wood Lane, W12 0BZ
About Me
I joined the Matthews Lab as a Research Assistant after completing my MSc in Translational Neuroscience at Imperial College London. With a background in Biomedical Science from King’s College London, my research journey has primarily focused on transcriptomics and genomics as part of the Multiomics Atlas Project. Following two years of enriching research experience, I commenced my PhD to explore how ABCA7 genetic variants contribute to the risk of Late-Onset Alzheimer’s disease, delving into the molecular and neuropathological pathways underlying this susceptibility. I am thrilled to continue working alongside a dynamic team in the Matthews Lab and the UKDRI at Imperial, contributing to research that targets dementia, a condition with far-reaching impacts on society.
Qualifications
- 2017-2021: BSc (First Class Hons) Biomedical Sciences, King’s College London
- 2021-2022: MSc Translational Neuroscience (Merit), Imperial College London
Research Interests
Molecular mechanisms of Alzheimer’s Disease, genetics of dementia, multi-omics, transcriptomics, genomics
Outreach
- Great Exhibition Road Festival 2024 – Activity Organiser
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Great Exhibition Road Festival 2023 – Volunteer
- ARUK 2023 – Poster Presentation
- Connectome 2023 – Poster Presentation
- Connectome 2025 – Poster Presentation
- ADPD 2025 – Poster Presentation
- ADPD 2026 – Invited for Oral Presentation
Publications
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Caramello A, Fancy N, Tournerie C, Eklund M, Chau V, Adair E, et al. Intracellular accumulation of amyloid-ß is a marker of selective neuronal vulnerability in Alzheimer’s disease. Nature Communications. 2025;16(1):5189.
- Fancy NN, Smith AM, Caramello A, Tsartsalis S, Davey K, Muirhead RCJ, et al. Characterisation of premature cell senescence in Alzheimer’s disease using single nuclear transcriptomics. Acta Neuropathologica. 2024;147(1):78.
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Stratton J, Yaqubi M, Thomas M, Talbot-Martin J, Mohammadnia A, Allot A, et al. Characterising processing conditions that artifactually bias human brain tissue transcriptomes. 2024.
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Schneegans E, Fancy N, Thomas M, Adair E, Willumsen N, Papageorgopoulou M, et al. Integrative multi-omics reveal glial signatures associated with accelerated cognitive decline in Alzheimer’s disease. medRxiv. 2024:2024.08.27.24312641.
Contact details
Email: marianna.papageorgopoulou@imperial.ac.uk
LinkedIn: marianna-papageorgopoulou-29a0b6153
