Zhongjie Yin

I have completed my PhD in the Department of Chemical Engineering. The aim of my project is to develop a strongly coupled, subject-specific FSI model capable of simulating the motion of aortic valve and its surrounding haemodynamics throughout a cardiac cycle. Model predictions will be compared with in vivo data. 

I completed my undergraduate study in Mechanical Engineering at the Anhui University of Technology, where I gained basic mathematics, physics, and mechanics knowledge. One day I came across the interdisciplinary field of cardiovascular biomechanics and found my mechanical engineering background could provide a different perspective, so I continued my MEng in Biomechanics and Medical Engineering at Peking University, where I completed my research topic of left ventricular wall biomechanical analysis in Cardiovascular Mechanics and Interventional Cardiology Laboratory.

Biography

2025 -
Commissioning Editor, Springer Nature, Shanghai, China

2020 - 2025
PhD in Chemical Engineering, Department of Chemical Engineering, Imperial College London, UK 

2017 - 2020
MEng in Biomechanics and Medical Engineering, College of Engineering, Peking University, China

2013 - 2017
BEng in Machine Design, Manufacturing and Its Automation, School of Mechanical Engineering, Anhui University of Technology, China  

Research Interests

My research interests include numerical simulations to explain how fluid, structure, and other factors interact in the cardiovascular system, how these interactions eventually lead to cardiovascular disease, and how medical devices play a role in changing these interactions and ultimately treating the disease.

Project Title

"Fluid-structure interaction analysis of natural and bioprosthetic aortic valves"

Supervisor(s)

Professor Xiao Yun Xu

Department of Chemical Engineering, Imperial College London, UK

Dr Saeed Mirsadraee

Royal Brompton and Harefield Hospitals, UK

Dr. Selene Pirola

Assistant Professor of Cardiovascular Biomechanics, BioMechanical Engineering, 3ME, TU Delft

Publications

• Yin, Z., Armour, C., Kandail, H., O’Regan, D. P., Bahrami, T., Mirsadraee, S., Pirola, S., & Xu, X. Y. (2025). The impact of coronary outflow and non‑Newtonian fluid property on aortic valve haemodynamics. Biomechanics and Modeling in Mechanobiology, 24(4), 1401–1416.
• Yin, Z., Armour, C., Pirola, S., Kandail, H., Kan, X., Garg, P., Li, R., Bahrami, T., Mirsadraee, S., & Xu, X. Y. (2025). A fully coupled fluid‑structure interaction model for patient‑specific analysis of bioprosthetic aortic valve haemodynamics. Frontiers in Bioengineering and Biotechnology, 13, Article 1584509. 
• Yin, Z., Armour, C., Kandail, H., O'Regan, D.P., Bahrami, T., Mirsadraee, S., Pirola, S. and Xu, X.Y., (2024). Fluid–structure interaction analysis of a healthy aortic valve and its surrounding haemodynamics. International Journal for Numerical Methods in Biomedical Engineering, p.e3865.
• Yin, Z., Zhang, W., Zhao, D., Sulejmani, F., Feng, Y., Huo, Y., & Tan, W. 2020. Cardiac wall mechanics analysis in hypertension-induced heart failure rats with preserved ejection fraction. Journal of biomechanics, 98, 109428.

Awards and Funding

Fully funded PhD scholarship awarded by the Department of Chemical Engineering, Imperial College London.

Teaching Experience

• Graduate teaching assistant in Department of Chemical Engineering, Imperial College London:      Reaction Design Project (Control Component)- 2nd Year Undergraduate (2022/23)
• Graduate teaching assistant in Department of Chemical Engineering, Imperial College London:
  Matlab Tutorial- 1st Year Undergraduate (2021/22)
• Graduate teaching assistant in College of Engineering, Peking University:
  Biofluid Mechanics- Postgraduate (2018/19)