Workshop, 16 November 2018
On Friday 16 November 2018, over 50 speakers and delegates attended a workshop convened by Professor Paul Matthews (Imperial College London) and Professor Henrik Zetterberg (UCL) at 58 Prince's Gate, South Kensington, London.
The workshop, sponsored by Biogen, was a huge success with excellent engagement and discussion throughout the day.
View the full programme, including slides and videos of our presentations and find out more about our speakers and their research by clicking on the links below.
Programme
Session I
- The neurobiology of neurofilaments, Jean-Pierre Julien, Laval University, Quebec
- Clinical observations of NfL and NfH in CSF and serum, Henrik Zetterberg, UK DRI
- Methodological considerations for assays for NfL and NfH, Jens Kuhle, University of Basel
Session I presentations
Session II
- Synaptic NfL and clearance of the protein, Ralph Nixon, NYU School of Medicine
- Mechanisms of protein clearance from the CNS compartment, Roy Weller, University of Southampton
- Degradation of intermediate filaments, Pascale Bomont, University of Montpellier
Session II presentations
Session III
- Neurofilament dynamics and its relevance to neurological disease, Heather Durham, Montreal Neurological Institute, McGill University
- Stable isotope studies of protein turnover in the CNS, Nicolas Barthelmy, Washington University School of Medicine, St Louis
Session III presentations
Speakers
Jean-Pierre Julien
Laval University, Quebec
The neurobiology of neurofilaments
Recommended publications:
Henrik Zetterberg
UCL
Clinical observations of NfL and NfH in CSF and serum
Recommended publications:
Jens Kuhle
University of Basel
Methodological considerations for assays for NfL and NfH
Recommended publications:
Speakers
Ralph Nixon
NYU School of Medicine
Synaptic NfL and clearance of the protein
Recommended publications:
Roy Weller
University of Southampton
Mechanisms of protein clearance from the CNS compartment
Recommended publications:
Speakers
Heather Durham
Montreal Neurological Institute, McGill University
Neurofilament dynamics and its relevance to neurological disease
Recommended publications:
Nicolas Barthelemy
Washington University School of Medicine, St Louis
Stable isotope studies of protein turnover in the CNS
Recommended publications:
Paul Matthews
Imperial College London
Meeting convener
View the full list of recommended publications.
A huge thank you to all involved in the workshop. We hope that the discussions continue. If you are keen to get involved or join in the conversation, please contact ukdri@imperial.ac.uk.
Finally, the organisers would like to thank Nicolas Barthelemy who, despite his best efforts, was unable to attend the meeting in person due to a plane situation beyond his control (see the photo for a clue as to what this was) but we are grateful that he was able to join us to give his presentation via a last minute webinar!
How temperature and circadian rhythms intersect to regulate a protein shown to protect against neurodegeneration
A new study led by Dr Marco Brancaccio (UK DRI at Imperial) and Dr Marieke Hoekstra (former UK DRI at Imperial, now VIB-KU Leuven Center for Brain & Disease Research) offers a deeper insight into how a neuroprotective pathway is regulated both by temperature and the body clock. This research, published in the journal PNAS, could open up new therapeutic avenues for neurodegenerative disease. Read more on the UK DRI website
Introducing Cynthia Sandor: Pioneering earlier detection of Parkinson’s
Dr Cynthia Sandor, former Emerging Leader at the UK DRI at Cardiff, joins the UK DRI at Imperial as a Group Leader, where she will be tackling early diagnosis of Parkinson’s.
With a background in genetics, Dr Sandor uses computational methods to bring greater understanding to the underlying molecular mechanisms of Parkinson’s. Read more about Cynthia's work on the UK DRI website.
