On Wednesday 04th October we will be welcoming speaker Professor Nicola J Mutch to the Vascular Science Seminar Series.

Details as follows:

Date: Wednesday 04th October

Time: 1 – 2pm (UK time) – please note this new time going forward for all VS seminar talks

Talk title: Cellular Connection with Fibrinolysis

Hosted by Professor Anna Randi

Location: Hybrid in person Room 527/528 Justin Mason Seminar 5th Floor, ICTEM Building, Hammersmith Campus and Online

Short Bio

Prof Nicola Mutch is a Personal Chair University of Aberdeen, Scotland.  She carried out her undergraduate and postgraduate studies at the University of Aberdeen specialising in haemostasis, thrombosis and vascular biology.  She subsequently moved to the University of Illinois for a post-doctoral position for 4 years before returning to her first independent position in Cardiovascular Biology at The University of Leeds.  She was awarded a personal fellowship from the British Heart Foundation and returned to the University of Aberdeen in 2012 to pursue her work and build an independent group.  Prof Mutch research interests focus on the physiological and pathological mechanisms underpinning haemostasis, thrombosis and vascular biology by employing a translational approach from basic protein biochemistry to modelling thrombosis and patient-based studies.  The overarching goal is to understand the mechanisms and drivers underpinning these cardiovascular and immunothrombotic diseases to develop and define more appropriate and personalised treatment strategies. Prof Mutch has served leadership roles in national and international haemostasis and thrombosis community, including the International Society of Thrombosis and Haemostasis, including Chair of the SSC of the ISTH; Chair of the Fibrinolysis subcommittee, Local planning committee for ISTH London 2022 and current Chair of the Annual Congress Planning Committee. She is Past Chair of the International Society of Fibrinolysis & Proteolysis and current President of the British Society of Haemostasis & Thrombosis. Prof Mutch serves on the Editorial board of the Journal of Thrombosis & Haemostasis, as an Associate Editor for Frontiers in Cardiovascular Disease, Thrombosis section and is an Editor of Platelets.

Talk Description

The talk will describe how firbinolysis, the process of the breakdown of fibrin, and plasminogen activation, generation of plasmin, are regulated on different cellular surfaces via various binding partners.  It will discuss the importance of shear stress in these reactions and importantly reveal that there are distinct differences in the behaviour of the plasminogen activators tPA and uPA.

A Vascular Science Seminar series site on MS Teams has been created for you to sign up to and join to be able to attend the seminar if you are joining online. To do so please click this link  which will request access to the Team site and Seminar if you are not already a member.

Please do this ahead of the seminar talk. 

VS Seminars Team

Getting here