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Conference paperDaly MJ, Goldstein DB, Rioux JD, et al., 2005,
Discussion
, Pages: 19-30, ISSN: 1528-2511 -
Conference paperAbbas AK, Cookson W, Foote SJ, et al., 2005,
Discussion
, Pages: 52-56, ISSN: 1528-2511 -
Conference paperCookson W, Rioux JD, Wijmenga C, et al., 2005,
Discussion
, Pages: 107-112, ISSN: 1528-2511 -
Conference paperBismarck A, Baltazar y Jimenez A, 2005,
Truly green composites: Fibre, polymer & interface characterisation
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Conference paperFeary JR, Crutchley J, Dowson LJ, 2005,
An audit of long term oxygen therapy in Wolverhampton: Implications for the new oxygen guidelines
, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: II64-II64, ISSN: 0040-6376 -
Conference paperHafler DA, Rao A, Goodnow CC, et al., 2005,
Discussion
, Pages: 192-199, ISSN: 1528-2511 -
Conference paperTing J, Wakeland EK, Wijmenga C, et al., 2005,
Discussion
, Pages: 88-93, ISSN: 1528-2511 -
Journal articleSafinia L, Datan N, Höhse M, et al., 2005,
Towards a methodology for the effective surface modification of porous polymer scaffolds
, BIOMATERIALS, Vol: 26, Pages: 7537-7547, ISSN: 0142-9612- Author Web Link
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- Citations: 74
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Journal articleHollax EJ, Davies J, Griesenbach U, et al., 2005,
Beta-defensin genomic copy number is not a modifier locus for cystic fibrosis
, J Negat Results Biomed, Vol: 7 -
Journal articleAdcock IM, Ito K, Barnes PJ, 2005,
Histone deacetylation: an important mechanism in inflammatory lung diseases.
, COPD, Vol: 2, Pages: 445-455, ISSN: 1541-2555Inflammatory lung diseases are characterised by increased expression of multiple inflammatory genes that are regulated by proinflammatory transcription factors, such as NF-kappaB. Gene expression is regulated by modifications such as acetylation of core histones through the concerted action of coactivators such as CBP (cAMP-response element binding protein (CREB)-binding protein) which have intrinsic histone acetyltransferase (HAT) activity and are able to recruit other HAT enzymes. Conversely gene repression is mediated via histone deacetylases (HDAC) and other corepressors. In biopsies from asthmatic subjects there is an increase in HAT activity and some reduction in HDAC activity. Both of these changes are partially reversed by corticosteroid therapy. Corticosteroids switch off inflammatory genes in asthma through a combination of a direct inhibition of HAT activity and by the recruitment of HDAC2 to the activated NF-kappaB-stimulated inflammatory gene complex. In chronic obstructive pulmonary disease (COPD), a corticosteroid insensitive disease, there is a reduction in HDAC activity and HDAC2 expression, which may account for the amplified inflammation and resistance to the actions of corticosteroids. The reduction in HDAC2 may be secondary to oxidative and nitrative stress as a result of cigarette smoking and severe inflammation. This may also occur to differing degrees in severe asthma, smoking asthmatic patients and cystic fibrosis. Similar mechanisms may also account for the steroid resistance seen within latent adenovirus infections. The reduction in HDAC activity induced by oxidative stress can be restored by theophylline, acting through specific kinases, which may be able to reverse steroid resistance in COPD and other inflammatory lung diseases. The modulation of HAT/HDAC activity may lead to the development of novel anti-inflammatory approaches to inflammatory lung diseases that are currently difficult to treat.
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