Search or filter publications

Search publications Search

Filter by type:

Filter by publication type

• Book
• Book chapter
• Conference paper
• Journal article
• Other
• Patent
• Poster
• Report
• Scholarly edition
• Software
• Thesis dissertation
• Working paper

Filter by year:

Filter from 202420232022202120202019201820172016201520142013201220112010200920082007200620052004200320022001200019991998199719961995199419931992199119901989198819871986198519841983198219811980197919781977197619751974197319721971197019691968 to Filter to 202420232022202120202019201820172016201520142013201220112010200920082007200620052004200320022001200019991998199719961995199419931992199119901989198819871986198519841983198219811980197919781977197619751974197319721971197019691968

---

Search results

• Journal article
  Donnelly CA, Fisher MC, Fraser C, Ghani AC, Riley S, Ferguson NM, Anderson RMet al., 2004,

  Epidemiological and genetic analysis of severe acute respiratory syndrome

  , Lancet Infectious Diseases, Vol: 4, Pages: 672-683, ISSN: 1473-3099

  The severe acute respiratory syndrome (SARS) epidemics in 2002–2003 showed how quickly a novel infectious disease can spread both within communities and internationally. We have reviewed the epidemiological and genetic analyses that have been published both during and since these epidemics, and show how quickly data were collected and analyses undertaken. Key factors that determine the speed and scale of transmission of an infectious disease were estimated using statistical and mathematical modelling approaches, and phylogenetic analyses provided insights into the origin and evolution of the SARS-associated coronavirus. The SARS literature continues to grow, and it is hoped that international collaboration in the analysis of epidemiological and contact-network databases will provide further insights into the spread of this newly emergent infectious disease.

  • Abstract
  • Publisher Web Link
  • Cite
• Journal article
  Bidartondo MI, Burghardt B, Gebauer G, Bruns TD, Read DJet al., 2004,

  Changing partners in the dark: isotopic and molecular evidence of ectomycorrhizal liaisons between forest orchids and trees.

  , Proceedings of the Royal Society B, Vol: 271, Pages: 1799-1806, ISSN: 0962-8452

  In the mycorrhizal symbiosis, plants exchange photosynthates for mineral nutrients acquired by fungi from the soil. This mutualistic arrangement has been subverted by hundreds of mycorrhizal plant species that lack the ability to photosynthesize. The most numerous examples of this behaviour are found in the largest plant family, the Orchidaceae. Although these non-photosynthetic orchid species are known to be highly specialized exploiters of the ectomycorrhizal symbiosis, photosynthetic orchids are thought to use free-living saprophytic, or pathogenic, fungal lineages. However, we present evidence that putatively photosynthetic orchids from five species which grow in the understorey of forests: (i) form mycorrhizas with ectomycorrhizal fungi of forest trees; and (ii) have stable isotope signatures indicating distinctive pathways for nitrogen and carbon acquisition approaching those of non-photosynthetic orchids that associate with ectomycorrhizal fungi of forest trees. These findings represent a major shift in our understanding of both orchid ecology and evolution because they explain how orchids can thrive in low-irradiance niches and they show that a shift to exploiting ectomycorrhizal fungi precedes viable losses of photosynthetic ability in orchid lineages.

  • Abstract
  • Cite
• Journal article
  Cosio BG, Tsaprouni L, Ito K, Jazrawi E, Adcock IM, Barnes PJet al., 2004,

  Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages

  , Journal of Experimental Medicine, Vol: 200, Pages: 689-695, ISSN: 1540-9538
  • Open Access Link
  • Cite
• Journal article
  Caramori G, Ito K, Adcock IM, 2004,

  Targeting Th2 cells in asthmatic airways.

  , Curr Drug Targets Inflamm Allergy, Vol: 3, Pages: 243-255, ISSN: 1568-010X

  The most effective anti-asthmatic drugs currently available include inhaled beta2-agonists and glucocorticoids and control asthma in about 95% of patients. The current asthma therapies are not cures and symptoms return soon after the treatment is stopped even after long-term therapy. In addition, severe glucocorticoid-dependent and -resistant asthma still represents a great clinical burden accounting for approximately 50% of the health care costs of asthma and reducing the side-effects of glucocorticoids using novel dissociated steroids, soft steroids or with steroid-sparing agents will prove beneficial. Furthermore, the mechanisms involved in the persistence of inflammation are poorly understood and the reasons why some patients have severe life threatening asthma and others have very mild disease are still unknown. Hopefully, it will soon be possible to identify and manipulate the molecular switches that result in asthmatic inflammation. This may lead to the treatment of susceptible individuals at birth or in the early years and thus prevent the disease from becoming established. Drug development for asthma has been directed at improving currently available drugs and finding new compounds that usually target the Th2-driven airway inflammatory response. Several new drugs have been developed to target specific components of the Th2-driven inflammatory process in asthma (e.g. IgE antibodies, cytokines and/or chemokines, immunomodulators, antagonists of adhesion molecules), although they have not yet been proven to be particularly effective. Some of these new Th2-oriented strategies may in the future not only control symptoms, but also potentially prevent or cure the disease.

  • Abstract
  • Author Web Link
  • Cite
• Journal article
  Weiland SK, Björkstén B, Brunekreef B, Cookson WOC, von Mutius E, Strachan DPet al., 2004,

  Phase II of the international study of asthma and allergies in childhood (ISAAC II):: rationale and methods

  , EUROPEAN RESPIRATORY JOURNAL, Vol: 24, Pages: 406-412, ISSN: 0903-1936
  • Author Web Link
  • Cite
  • Citations: 336
• Journal article
  Fisher MC, De Hoog S, Vanittanakom N, 2004,

  A highly discriminatory multilocus microsatellite typing (MLMT) system for <i>Penicillium marneffei</i>

  , MOLECULAR ECOLOGY NOTES, Vol: 4, Pages: 515-518, ISSN: 1471-8278
  • Author Web Link
  • Cite
  • Citations: 20
• Journal article
  Anderson KL, Billington J, Pettigrew D, Cota E, Simpson P, Roversi P, Chen HA, Urvil P, du Merle L, Barlow PN, Medof ME, Smith RAG, Nowicki B, Le Bouguénec C, Lea SM, Matthews Set al., 2004,

  An atomic resolution model for assembly, architecture, and function of the Dr adhesins

  , MOLECULAR CELL, Vol: 15, Pages: 647-657, ISSN: 1097-2765
  • Author Web Link
  • Cite
  • Citations: 97
• Journal article
  Leake JR, McKendrick SL, Bidartondo M, Read DJet al., 2004,

  Symbiotic germination and development of the myco-heterotroph Monotropa hypopitys in nature and its requirement for locally distributed Tricholoma spp.

  , New Phytologist, Vol: 163, Pages: 405-423, ISSN: 0028-646X

  Germination and symbiotic development of the myco-heterotrophic plant Monotropa hypopitys were studied by sequential recovery of packets of seed buried in dune slacks in relation to distance from mature M. hypopitys and presence and absence of shoots of its autotrophic coassociate Salix repens.Fungal associates of M. hypopitys growing under S. repens in the dune slacks, and under S. caprea and Pinus sylvestris at two other locations in the UK, were identified by molecular analysis.While the earliest stage of germination could be found in the absence both of mature M. hypopitys, and S. repens, further development was dependent upon mycorrhizal colonisation, which was most common close to these plants. Molecular analysis showed that when growing with Salix, M. hypopitys associated with the Salix-specific ectomycorrhizal fungus Tricholoma cingulatum, whereas under Pinus it was colonised by the closely related, Pinaceae-specific, T. terreum.We establish the first definitive chronology of development of M. hypopitys and highlight its critical dependence upon, and specificity for, locally distributed Tricholoma species that link the myco-heterotroph to its autotrophic coassociates. (C) New Phytologist (2004).

  • Abstract
  • Cite
• Journal article
  Caramori G, Ito K, Adcock IM, 2004,

  Transcription factors in asthma and COPD

  , IDRUGS, Vol: 7, Pages: 764-770, ISSN: 1369-7056
  • Author Web Link
  • Cite
  • Citations: 13
• Journal article
  Desai SR, Veeraraghavan S, Hanser DM, Nikolakopolou A, Goh NSL, Nicholson AG, Colby TV, Denton CP, Black CM, Ois RMD, Wells AUet al., 2004,

  CT features of lung disease in patients with systemic sclerosis: Comparison with idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia

  , RADIOLOGY, Vol: 232, Pages: 560-567, ISSN: 0033-8419
  • Author Web Link
  • Cite
  • Citations: 246

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.