@article{Swann:2020:10.1101/2020.07.14.20153320,
author = {Swann, OV and Holden, K and Turtle, L and Pollock, L and Fairfield, CJ and Drake, TM and Seth, S and Egan, C and Hardwick, HE and Halpin, S and Girvan, M and Donohue, C and Pritchard, M and Patel, LB and Ladhani, S and Sigfrid, L and Sinha, IP and Olliaro, P and Nguyen-Van-Tam, JS and Horby, PW and Merson, L and Carson, G and Dunning, J and Openshaw, PJM and Baillie, JK and Harrison, EM and Docherty, A and Semple, MG},
doi = {10.1101/2020.07.14.20153320},
title = {Clinical characteristics of children and young people hospitalised with covid-19 in the United Kingdom: prospective multicentre observational cohort study},
url = {http://dx.doi.org/10.1101/2020.07.14.20153320},
year = {2020}
}

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TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>To characterise the clinical features of children and young people admitted to hospital with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the UK, and explore factors associated with admission to critical care, mortality, and development of multisystem inflammatory syndrome in children and adolescents temporarily related to covid-19 (MIS-C).</jats:p></jats:sec><jats:sec><jats:title>Design</jats:title><jats:p>Prospective observational cohort study with rapid data gathering and near real time analysis.</jats:p></jats:sec><jats:sec><jats:title>Setting</jats:title><jats:p>260 acute care hospitals in England, Wales, and Scotland between 17th January and 5<jats:sup>th</jats:sup>June 2020, with a minimal follow-up time of two weeks (to 19<jats:sup>th</jats:sup>June 2020).</jats:p></jats:sec><jats:sec><jats:title>Participants</jats:title><jats:p>451 children and young people aged less than 19 years admitted to 116 hospitals and enrolled into the International Severe Acute Respiratory and emergency Infections Consortium (ISARIC) WHO Clinical Characterisation Protocol UK study with laboratory-confirmed SARS-CoV-2.</jats:p></jats:sec><jats:sec><jats:title>Main Outcome Measures</jats:title><jats:p>Admission to critical care (high dependency or intensive care), in-hospital mortality, or meeting the WHO preliminary case definition for MIS-C.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Median age was 3.9 years [interquartile range (IQR) 0.3-12.9 years], 36% (162/451) were under 12 months old, and 57% (256/450) were male. 56% (224/401) were White, 12% (49/401) South Asian and 10% (40/401) B
AU  - Swann,OV
AU  - Holden,K
AU  - Turtle,L
AU  - Pollock,L
AU  - Fairfield,CJ
AU  - Drake,TM
AU  - Seth,S
AU  - Egan,C
AU  - Hardwick,HE
AU  - Halpin,S
AU  - Girvan,M
AU  - Donohue,C
AU  - Pritchard,M
AU  - Patel,LB
AU  - Ladhani,S
AU  - Sigfrid,L
AU  - Sinha,IP
AU  - Olliaro,P
AU  - Nguyen-Van-Tam,JS
AU  - Horby,PW
AU  - Merson,L
AU  - Carson,G
AU  - Dunning,J
AU  - Openshaw,PJM
AU  - Baillie,JK
AU  - Harrison,EM
AU  - Docherty,A
AU  - Semple,MG
DO  - 10.1101/2020.07.14.20153320
PY  - 2020///
TI  - Clinical characteristics of children and young people hospitalised with covid-19 in the United Kingdom: prospective multicentre observational cohort study
UR  - http://dx.doi.org/10.1101/2020.07.14.20153320
ER  - 

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