BibTex format
@article{Nhan:2019:ofid/ofz284,
author = {Nhan, LNT and Turner, HC and Khanh, TH and Hung, NT and Lien, LB and Hong, NTT and Nhu, LNT and Ny, NTH and Nguyet, LA and Thanh, TT and Van, HMT and Viet, HL and Tung, TH and Phuong, TTL and Devine, A and Thwaites, G and Chau, NVV and Thwaites, L and van, Doorn HR and Tan, LV},
doi = {ofid/ofz284},
journal = {Open Forum Infectious Diseases},
title = {Economic burden attributed to children presenting to hospitals with hand, foot, and mouth disease in Vietnam},
url = {http://dx.doi.org/10.1093/ofid/ofz284},
volume = {6},
year = {2019}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - BACKGROUND: Hand, foot, and mouth disease (HFMD) has become a major public health concern in the Asia-Pacific region. Knowledge of its economic burden is essential for policy makers in prioritizing the development and implementation of interventions. METHODS: A multi-hospital-based study was prospectively conducted at 3 major hospitals in Ho Chi Minh City, Vietnam, during 2016-2017. Data on direct and productivity costs were collected alongside clinical information and samples and demographic information from study participants. RESULTS: A total of 466 patients were enrolled. Two hundred three of 466 (43.6%) patients lived in Ho Chi Minh City, and 72/466 (15.5%) had severe HFMD. An enterovirus was identified in 74% of 466 patients, with EV-A71, CV-A6, CV-A10, and CV-A16 being the most common viruses identified (236/466, 50.6%). The mean economic burden per case was estimated at US$400.80 (95% confidence interval [CI], $353.80-$448.90), of which the total direct (medical) costs accounted for 69.7%. There were considerable differences in direct medical costs between groups of patients with different clinical severities and pathogens (ie, EV-A71 vs non-EV-A71). In Vietnam, during 2016-2017, the economic burden posed by HFMD was US$90 761 749 (95% CI, $79 033 973-$103 009 756). CONCLUSIONS: Our findings are of public health significance because for the first time we demonstrate that HFMD causes a substantial economic burden in Vietnam, and although multivalent vaccines are required to control HFMD, effective EV-A71 vaccine could substantially reduce the burden posed by severe HFMD. The results will be helpful for health policy makers in prioritizing resources for the development and implementation of intervention strategies to reduce the burden of HFMD.
AU - Nhan,LNT
AU - Turner,HC
AU - Khanh,TH
AU - Hung,NT
AU - Lien,LB
AU - Hong,NTT
AU - Nhu,LNT
AU - Ny,NTH
AU - Nguyet,LA
AU - Thanh,TT
AU - Van,HMT
AU - Viet,HL
AU - Tung,TH
AU - Phuong,TTL
AU - Devine,A
AU - Thwaites,G
AU - Chau,NVV
AU - Thwaites,L
AU - van,Doorn HR
AU - Tan,LV
DO - ofid/ofz284
PY - 2019///
SN - 2328-8957
TI - Economic burden attributed to children presenting to hospitals with hand, foot, and mouth disease in Vietnam
T2 - Open Forum Infectious Diseases
UR - http://dx.doi.org/10.1093/ofid/ofz284
UR - https://www.ncbi.nlm.nih.gov/pubmed/31363772
VL - 6
ER -