BibTex format
@article{Hill:2019:10.1101/520437,
author = {Hill, SC and Vasconcelos, J and Neto, Z and Jandondo, D and Zé-Zé, L and Aguiar, RS and Xavier, J and Thézé, J and Mirandela, M and Cândido, ALM and Vaz, F and Sebastião, CDS and Wu, C-H and Kraemer, M and Melo, A and Schamber-Reis, BLF and de, Azevedo GS and Tanuri, A and Higa, LM and Clemente, C and da, Silva SP and da, Silva Candido D and Claro, IM and Domingos, Quibuco N and Domingos, C and Pocongo, B and Watts, AG and Khan, K and Alcantara, LCJ and Sabino, EC and Lackritz, E and Pybus, OG and Alves, M-J and Afonso, J and Faria, NR},
doi = {10.1101/520437},
title = {Emergence of the Zika virus Asian lineage in Angola},
url = {http://dx.doi.org/10.1101/520437},
year = {2019}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - <jats:sec><jats:title>Research In Context</jats:title><jats:sec><jats:title>Evidence before this study</jats:title><jats:p>We searched PubMed without language restrictions using the keywords ‘Zika’ and ‘Africa’ for papers published to October 2018. We also checked available ‘Situation Report’ publications from WHO for evidence of Zika virus (ZIKV) or congenital Zika disease in Africa. ZIKV African lineage has been detected within Africa since the mid 20<jats:sup>th</jats:sup> century, yet evidence for spread of the ZIKV Asian lineage within Africa is limited. Two countries in Africa (Cabo Verde and Angola) have reported ZIKV cases that are believed to be caused by a newly introduced Asian lineage virus. Sequence data are critical for confirming and understanding the spread of ZIKV Asian lineage within Africa, but these data are currently limited to a single 193bp fragment of the ZIKV NS1 gene from Angola. In addition, whilst epidemiological data on ZIKV and suspected microcephaly cases have been reported in detail from Cabo Verde, data from Angola are extremely limited.</jats:p></jats:sec><jats:sec><jats:title>Added value of this study</jats:title><jats:p>We provide a detailed report of detected ZIKV acute cases and suspected microcephaly cases in Angola. We sequence ZIKV genomes from three acutely infected cases. These represent the first three Asian lineage genomes available from Africa, one of which was acquired from a baby with confirmed microcephaly. Analysis of these sequences suggests that ZIKV may have been introduced to Angola between July 2015 and June 2016, after which it likely circulated for at least one year. This provides the first genetic confirmation of autochthonous ZIKV Asian lineage transmission within Africa. We suggest that the virus was more likely introduced to Angola directly from Brazil, rather than from Cabo Verde.
AU - Hill,SC
AU - Vasconcelos,J
AU - Neto,Z
AU - Jandondo,D
AU - Zé-Zé,L
AU - Aguiar,RS
AU - Xavier,J
AU - Thézé,J
AU - Mirandela,M
AU - Cândido,ALM
AU - Vaz,F
AU - Sebastião,CDS
AU - Wu,C-H
AU - Kraemer,M
AU - Melo,A
AU - Schamber-Reis,BLF
AU - de,Azevedo GS
AU - Tanuri,A
AU - Higa,LM
AU - Clemente,C
AU - da,Silva SP
AU - da,Silva Candido D
AU - Claro,IM
AU - Domingos,Quibuco N
AU - Domingos,C
AU - Pocongo,B
AU - Watts,AG
AU - Khan,K
AU - Alcantara,LCJ
AU - Sabino,EC
AU - Lackritz,E
AU - Pybus,OG
AU - Alves,M-J
AU - Afonso,J
AU - Faria,NR
DO - 10.1101/520437
PY - 2019///
TI - Emergence of the Zika virus Asian lineage in Angola
UR - http://dx.doi.org/10.1101/520437
UR - https://doi.org/10.1101/520437
ER -