BibTex format
@article{Faria:2017:10.1101/105171,
author = {Faria, NR and Quick, J and Morales, I and Thézé, J and Jesus, JG and Giovanetti, M and Kraemer, MUG and Hill, SC and Black, A and da, Costa AC and Franco, LC and Silva, SP and Wu, C-H and Raghwani, J and Cauchemez, S and du, Plessis L and Verotti, MP and de, Oliveira WK and Carmo, EH and Coelho, GE and Santelli, ACFS and Vinhal, LC and Henriques, CM and Simpson, JT and Loose, M and Andersen, KG and Grubaugh, ND and Somasekar, S and Chiu, CY and Muñoz-Medina, JE and Gonzalez-Bonilla, CR and Arias, CF and Lewis-Ximenez, LL and Baylis, SA and Chieppe, AO and Aguiar, SF and Fernandes, CA and Lemos, PS and Nascimento, BLS and Monteiro, HAO and Siqueira, IC and de, Queiroz MG and de, Souza TR and Bezerra, JF and Lemos, MR and Pereira, GF and Loudal, D and Moura, LC and Dhalia, R and França, RF and Magalhães, T and Marques, ET and Jaenisch, T and Wallau, GL and de, Lima MC and Nascimento, V and de, Cerqueira EM and de, Lima MM and Mascarenhas, DL and Moura, Neto JP and Levin, AS and Tozetto-M},
doi = {10.1101/105171},
title = {Epidemic establishment and cryptic transmission of Zika virus in Brazil and the Americas},
url = {http://dx.doi.org/10.1101/105171},
year = {2017}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - <jats:p>Zika virus (ZIKV) transmission in the Americas was first confirmed in May 2015 in Northeast Brazil<jats:sup>1</jats:sup>. Brazil has the highest number of reported ZIKV cases worldwide (>200,000 by 24 Dec 2016<jats:sup>2</jats:sup>) as well as the greatest number of cases associated with microcephaly and other birth defects (2,366 confirmed cases by 31 Dec 2016<jats:sup>2</jats:sup>). Following the initial detection of ZIKV in Brazil, 47 countries and territories in the Americas have reported local ZIKV transmission, with 24 of these reporting ZIKV-associated severe disease<jats:sup>3</jats:sup>. Yet the origin and epidemic history of ZIKV in Brazil and the Americas remain poorly understood, despite the value of such information for interpreting past and future trends in reported microcephaly. To address this we generated 54 complete or partial ZIKV genomes, mostly from Brazil, and report data generated by the ZiBRA project – a mobile genomics lab that travelled across Northeast (NE) Brazil in 2016. One sequence represents the earliest confirmed ZIKV infection in Brazil. Joint analyses of viral genomes with ecological and epidemiological data estimate that ZIKV epidemic was present in NE Brazil by March 2014 and likely disseminated from there, both nationally and internationally, before the first detection of ZIKV in the Americas. Estimated dates of the international spread of ZIKV from Brazil indicate the duration of pre-detection cryptic transmission in recipient regions. NE Brazil’s role in the establishment of ZIKV in the Americas is further supported by geographic analysis of ZIKV transmission potential and by estimates of the virus’ basic reproduction number.</jats:p><jats:sec><jats:title>One Sentence Summary</jats:title><jats:p>Virus genomes reveal the establishment of Zika virus in Brazil and the Americas, and provide an appropriate timeframe
AU - Faria,NR
AU - Quick,J
AU - Morales,I
AU - Thézé,J
AU - Jesus,JG
AU - Giovanetti,M
AU - Kraemer,MUG
AU - Hill,SC
AU - Black,A
AU - da,Costa AC
AU - Franco,LC
AU - Silva,SP
AU - Wu,C-H
AU - Raghwani,J
AU - Cauchemez,S
AU - du,Plessis L
AU - Verotti,MP
AU - de,Oliveira WK
AU - Carmo,EH
AU - Coelho,GE
AU - Santelli,ACFS
AU - Vinhal,LC
AU - Henriques,CM
AU - Simpson,JT
AU - Loose,M
AU - Andersen,KG
AU - Grubaugh,ND
AU - Somasekar,S
AU - Chiu,CY
AU - Muñoz-Medina,JE
AU - Gonzalez-Bonilla,CR
AU - Arias,CF
AU - Lewis-Ximenez,LL
AU - Baylis,SA
AU - Chieppe,AO
AU - Aguiar,SF
AU - Fernandes,CA
AU - Lemos,PS
AU - Nascimento,BLS
AU - Monteiro,HAO
AU - Siqueira,IC
AU - de,Queiroz MG
AU - de,Souza TR
AU - Bezerra,JF
AU - Lemos,MR
AU - Pereira,GF
AU - Loudal,D
AU - Moura,LC
AU - Dhalia,R
AU - França,RF
AU - Magalhães,T
AU - Marques,ET
AU - Jaenisch,T
AU - Wallau,GL
AU - de,Lima MC
AU - Nascimento,V
AU - de,Cerqueira EM
AU - de,Lima MM
AU - Mascarenhas,DL
AU - Moura,Neto JP
AU - Levin,AS
AU - Tozetto-Mendoza,TR
AU - Fonseca,SN
AU - Mendes-Correa,MC
AU - Milagres,FP
AU - Segurado,A
AU - Holmes,EC
AU - Rambaut,A
AU - Bedford,T
AU - Nunes,MRT
AU - Sabino,EC
AU - Alcantara,LCJ
AU - Loman,N
AU - Pybus,OG
DO - 10.1101/105171
PY - 2017///
TI - Epidemic establishment and cryptic transmission of Zika virus in Brazil and the Americas
UR - http://dx.doi.org/10.1101/105171
UR - https://doi.org/10.1101/105171
ER -