BibTex format
@article{Grubaugh:2017:10.1101/104794,
author = {Grubaugh, ND and Ladner, JT and Kraemer, MUG and Dudas, G and Tan, AL and Gangavarapu, K and Wiley, MR and White, S and Thézé, J and Magnani, DM and Prieto, K and Reyes, D and Bingham, A and Paul, LM and Robles-Sikisaka, R and Oliveira, G and Pronty, D and Metsky, HC and Baniecki, ML and Barnes, KG and Chak, B and Freije, CA and Gladden-Young, A and Gnirke, A and Luo, C and MacInnis, B and Matranga, CB and Park, DJ and Qu, J and Schaffner, SF and Tomkins-Tinch, C and West, KL and Winnicki, SM and Wohl, S and Yozwiak, NL and Quick, J and Fauver, JR and Khan, K and Brent, SE and Reiner, RC and Lichtenberger, PN and Ricciardi, M and Bailey, VK and Watkins, DI and Cone, MR and Kopp, EW and Hogan, KN and Cannons, AC and Jean, R and Garry, RF and Loman, NJ and Faria, NR and Porcelli, MC and Vasquez, C and Nagle, ER and Cummings, DAT and Stanek, D and Rambaut, A and Sanchez-Lockhart, M and Sabeti, PC and Gillis, LD and Michael, SF and Bedford, T and Pybus, OG and Isern, S and Palacios, G and },
doi = {10.1101/104794},
title = {Multiple introductions of Zika virus into the United States revealed through genomic epidemiology},
url = {http://dx.doi.org/10.1101/104794},
year = {2017}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - <jats:p>Zika virus (ZIKV) is causing an unprecedented epidemic linked to severe congenital syndromes<jats:sup>1,2</jats:sup>. In July 2016, mosquito-borne ZIKV transmission was first reported in the continental United States and since then, hundreds of locally-acquired infections have been reported in Florida<jats:sup>3</jats:sup>. To gain insights into the timing, source, and likely route(s) of introduction of ZIKV into the continental United States, we tracked the virus from its first detection in Miami, Florida by direct sequencing of ZIKV genomes from infected patients and<jats:italic>Aedes aegypti</jats:italic>mosquitoes. We show that at least four distinct ZIKV introductions contributed to the outbreak in Florida and that local transmission likely started in the spring of 2016 - several months before its initial detection. By analyzing surveillance and genetic data, we discovered that ZIKV moved among transmission zones in Miami. Our analyses show that most introductions are phylogenetically linked to the Caribbean, a finding corroborated by the high incidence rates and traffic volumes from the region into the Miami area. By comparing mosquito abundance and travel flows, we describe the areas of southern Florida that are especially vulnerable to ZIKV introductions. Our study provides a deeper understanding of how ZIKV initiates and sustains transmission in new regions.</jats:p>
AU - Grubaugh,ND
AU - Ladner,JT
AU - Kraemer,MUG
AU - Dudas,G
AU - Tan,AL
AU - Gangavarapu,K
AU - Wiley,MR
AU - White,S
AU - Thézé,J
AU - Magnani,DM
AU - Prieto,K
AU - Reyes,D
AU - Bingham,A
AU - Paul,LM
AU - Robles-Sikisaka,R
AU - Oliveira,G
AU - Pronty,D
AU - Metsky,HC
AU - Baniecki,ML
AU - Barnes,KG
AU - Chak,B
AU - Freije,CA
AU - Gladden-Young,A
AU - Gnirke,A
AU - Luo,C
AU - MacInnis,B
AU - Matranga,CB
AU - Park,DJ
AU - Qu,J
AU - Schaffner,SF
AU - Tomkins-Tinch,C
AU - West,KL
AU - Winnicki,SM
AU - Wohl,S
AU - Yozwiak,NL
AU - Quick,J
AU - Fauver,JR
AU - Khan,K
AU - Brent,SE
AU - Reiner,RC
AU - Lichtenberger,PN
AU - Ricciardi,M
AU - Bailey,VK
AU - Watkins,DI
AU - Cone,MR
AU - Kopp,EW
AU - Hogan,KN
AU - Cannons,AC
AU - Jean,R
AU - Garry,RF
AU - Loman,NJ
AU - Faria,NR
AU - Porcelli,MC
AU - Vasquez,C
AU - Nagle,ER
AU - Cummings,DAT
AU - Stanek,D
AU - Rambaut,A
AU - Sanchez-Lockhart,M
AU - Sabeti,PC
AU - Gillis,LD
AU - Michael,SF
AU - Bedford,T
AU - Pybus,OG
AU - Isern,S
AU - Palacios,G
AU - Andersen,KG
DO - 10.1101/104794
PY - 2017///
TI - Multiple introductions of Zika virus into the United States revealed through genomic epidemiology
UR - http://dx.doi.org/10.1101/104794
UR - https://doi.org/10.1101/104794
ER -