BibTex format
@article{Chung:2021:10.1002/ijgo.13466,
author = {Chung, MH and De, Vuyst H and Greene, SA and Topazian, HM and Sayed, S and Moloo, Z and Cagle, A and Nyongesa-Malava, E and Luchters, S and Temmerman, M and Sakr, SR and Mugo, NR and McGrath, CJ},
doi = {10.1002/ijgo.13466},
journal = {International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics},
pages = {118--124},
title = {Loop electrosurgical excision procedure (LEEP) plus top hat for HIV-infected women with endocervical intraepithelial neoplasia in Kenya.},
url = {http://dx.doi.org/10.1002/ijgo.13466},
volume = {152},
year = {2021}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - OBJECTIVE: To determine the utility of detecting endocervical cervical intraepithelial neoplasia (CIN) 2+ with endocervical curettage (ECC) and treating with loop electrosurgical excision procedure (LEEP) plus top hat (+TH) among women with HIV. METHODS: Cytology was followed by coloscopy-directed biopsy if participants had HSIL or ASC-H and biopsy plus ECC if there were glandular cells present. CIN2/3 on ECC and/or inadequate colposcopy (ENL) was treated with LEEP+TH, while CIN2/3 on ectocervix (ECL) received LEEP alone. Recurrent CIN2+ were compared over a 2-year follow-up. RESULTS: Of 5330 participants, 160 underwent ECC, 98 were CIN2/3 on ECC, and 77 received LEEP+TH. ECC detected 15 (9%) more women with CIN2/3 than biopsy alone. Women were more likely to have ENL if they were older (≥45 vs <35 years) (adjusted relative risk [aRR] 2.14; P = 0.009) and on antiretroviral treatment longer (≥2 vs <2 years) (aRR 3.97; P < 0.001). Over the 2-year follow-up, 35 (29%) ENL had recurrent CIN2+ after TH compared to 19 (24%) ECL after LEEP (hazard ratio 1.32; 95% confidence interval 0.75-2.31; P = 0.338). CONCLUSION: Among HIV-infected women, adding ECC did not increase detection of pre-cancerous disease significantly and treatment with LEEP+TH for ENL was comparable to treatment with LEEP for ECL.
AU - Chung,MH
AU - De,Vuyst H
AU - Greene,SA
AU - Topazian,HM
AU - Sayed,S
AU - Moloo,Z
AU - Cagle,A
AU - Nyongesa-Malava,E
AU - Luchters,S
AU - Temmerman,M
AU - Sakr,SR
AU - Mugo,NR
AU - McGrath,CJ
DO - 10.1002/ijgo.13466
EP - 124
PY - 2021///
SP - 118
TI - Loop electrosurgical excision procedure (LEEP) plus top hat for HIV-infected women with endocervical intraepithelial neoplasia in Kenya.
T2 - International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
UR - http://dx.doi.org/10.1002/ijgo.13466
VL - 152
ER -