BibTex format
@article{Sabino:2022:10.3390/v14051042,
author = {Sabino, JS and Amorim, MR and de, Souza WM and Marega, LF and Mofatto, LS and Toledo-Teixeira, DA and Forato, J and Stabeli, RG and Costa, ML and Spilki, FR and Sabino, EC and Faria, NR and Benites, BD and Addas-Carvalho, M and Stucchi, RSB and Vasconcelos, DM and Weaver, SC and Granja, F and Proenca-Modena, JL and Vilela, MMDS},
doi = {10.3390/v14051042},
journal = {Viruses-Basel},
title = {Clearance of persistent SARS-CoV-2 RNA detection in a NF kappa B-Deficient patient in association with the ingestion of human breast milk: a case report},
url = {http://dx.doi.org/10.3390/v14051042},
volume = {14},
year = {2022}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Currently, there are no evidence-based treatment options for long COVID-19, and it is known that SARS-CoV-2 can persist in part of the infected patients, especially those with immunosuppression. Since there is a robust secretion of SARS-CoV-2-specific highly-neutralizing IgA antibodies in breast milk, and because this immunoglobulin plays an essential role against respiratory virus infection in mucosa cells, being, in addition, more potent in neutralizing SARS-CoV-2 than IgG, here we report the clinical course of an NFκB-deficient patient chronically infected with the SARS-CoV-2 Gamma variant, who, after a non-full effective treatment with plasma infusion, received breast milk from a vaccinated mother by oral route as treatment for COVID-19. After such treatment, the symptoms improved, and the patient was systematically tested negative for SARS-CoV-2. Thus, we hypothesize that IgA and IgG secreted antibodies present in breast milk could be useful to treat persistent SARS-CoV-2 infection in immunodeficient patients
AU - Sabino,JS
AU - Amorim,MR
AU - de,Souza WM
AU - Marega,LF
AU - Mofatto,LS
AU - Toledo-Teixeira,DA
AU - Forato,J
AU - Stabeli,RG
AU - Costa,ML
AU - Spilki,FR
AU - Sabino,EC
AU - Faria,NR
AU - Benites,BD
AU - Addas-Carvalho,M
AU - Stucchi,RSB
AU - Vasconcelos,DM
AU - Weaver,SC
AU - Granja,F
AU - Proenca-Modena,JL
AU - Vilela,MMDS
DO - 10.3390/v14051042
PY - 2022///
SN - 1999-4915
TI - Clearance of persistent SARS-CoV-2 RNA detection in a NF kappa B-Deficient patient in association with the ingestion of human breast milk: a case report
T2 - Viruses-Basel
UR - http://dx.doi.org/10.3390/v14051042
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000804365100001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - https://www.mdpi.com/1999-4915/14/5/1042
VL - 14
ER -