BibTex format
@article{Zody:2006:10.1038/nature04601,
author = {Zody, MC and Garber, M and Sharpe, T and Young, SK and Rowen, L and O'Neill, K and Whittaker, CA and Kamal, M and Chang, JL and Cuomo, CA and Dewar, K and FitzGerald, MG and Kodira, CD and Madan, A and Qin, S and Yang, X and Abbasi, N and Abouelleil, A and Arachchi, HM and Baradarani, L and Birditt, B and Bloom, S and Bloom, T and Borowsky, ML and Burke, J and Butler, J and Cook, A and DeArellano, K and DeCaprio, D and Dorris, L and Dors, M and Eichler, EE and Engels, R and Fahey, J and Fleetwood, P and Friedman, C and Gearin, G and Hall, JL and Hensley, G and Johnson, E and Jones, C and Kamat, A and Kaur, A and Locke, DP and Madan, A and Munson, G and Jaffe, DB and Lui, A and Macdonald, P and Mauceli, E and Naylor, JW and Nesbitt, R and Nicol, R and O'Leary, SB and Ratcliffe, A and Rounsley, S and She, X and Sneddon, KMB and Stewart, S and Sougnez, C and Stone, SM and Topham, K and Vincent, D and Wang, S and Zimmer, AR and Birren, BW and Hood, L and Lander, ES and Nusbaum, C},
doi = {10.1038/nature04601},
journal = {Nature},
pages = {671--675},
title = {Analysis of the DNA sequence and duplication history of human chromosome 15.},
url = {http://dx.doi.org/10.1038/nature04601},
volume = {440},
year = {2006}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Here we present a finished sequence of human chromosome 15, together with a high-quality gene catalogue. As chromosome 15 is one of seven human chromosomes with a high rate of segmental duplication, we have carried out a detailed analysis of the duplication structure of the chromosome. Segmental duplications in chromosome 15 are largely clustered in two regions, on proximal and distal 15q; the proximal region is notable because recombination among the segmental duplications can result in deletions causing Prader-Willi and Angelman syndromes. Sequence analysis shows that the proximal and distal regions of 15q share extensive ancient similarity. Using a simple approach, we have been able to reconstruct many of the events by which the current duplication structure arose. We find that most of the intrachromosomal duplications seem to share a common ancestry. Finally, we demonstrate that some remaining gaps in the genome sequence are probably due to structural polymorphisms between haplotypes; this may explain a significant fraction of the gaps remaining in the human genome.
AU - Zody,MC
AU - Garber,M
AU - Sharpe,T
AU - Young,SK
AU - Rowen,L
AU - O'Neill,K
AU - Whittaker,CA
AU - Kamal,M
AU - Chang,JL
AU - Cuomo,CA
AU - Dewar,K
AU - FitzGerald,MG
AU - Kodira,CD
AU - Madan,A
AU - Qin,S
AU - Yang,X
AU - Abbasi,N
AU - Abouelleil,A
AU - Arachchi,HM
AU - Baradarani,L
AU - Birditt,B
AU - Bloom,S
AU - Bloom,T
AU - Borowsky,ML
AU - Burke,J
AU - Butler,J
AU - Cook,A
AU - DeArellano,K
AU - DeCaprio,D
AU - Dorris,L
AU - Dors,M
AU - Eichler,EE
AU - Engels,R
AU - Fahey,J
AU - Fleetwood,P
AU - Friedman,C
AU - Gearin,G
AU - Hall,JL
AU - Hensley,G
AU - Johnson,E
AU - Jones,C
AU - Kamat,A
AU - Kaur,A
AU - Locke,DP
AU - Madan,A
AU - Munson,G
AU - Jaffe,DB
AU - Lui,A
AU - Macdonald,P
AU - Mauceli,E
AU - Naylor,JW
AU - Nesbitt,R
AU - Nicol,R
AU - O'Leary,SB
AU - Ratcliffe,A
AU - Rounsley,S
AU - She,X
AU - Sneddon,KMB
AU - Stewart,S
AU - Sougnez,C
AU - Stone,SM
AU - Topham,K
AU - Vincent,D
AU - Wang,S
AU - Zimmer,AR
AU - Birren,BW
AU - Hood,L
AU - Lander,ES
AU - Nusbaum,C
DO - 10.1038/nature04601
EP - 675
PY - 2006///
SP - 671
TI - Analysis of the DNA sequence and duplication history of human chromosome 15.
T2 - Nature
UR - http://dx.doi.org/10.1038/nature04601
UR - https://www.ncbi.nlm.nih.gov/pubmed/16572171
VL - 440
ER -