In this section
@article{Wong:2007:10.1073/pnas.0705499104,
author = {Wong, SY and Haack, H and Kissil, JL and Barry, M and Bronson, RT and Shen, SS and Whittaker, CA and Crowley, D and Hynes, RO},
doi = {10.1073/pnas.0705499104},
journal = {Proc Natl Acad Sci U S A},
pages = {12784--12789},
title = {Protein 4.1B suppresses prostate cancer progression and metastasis.},
url = {http://dx.doi.org/10.1073/pnas.0705499104},
volume = {104},
year = {2007}
}
TY - JOUR
AB - Protein 4.1B is a 4.1/ezrin/radixin/moesin domain-containing protein whose expression is frequently lost in a variety of human tumors, including meningiomas, non-small-cell lung cancers, and breast carcinomas. However, its potential tumor-suppressive function under in vivo conditions remains to be validated. In a screen for genes involved with prostate cancer metastasis, we found that 4.1B expression is reduced in highly metastatic tumors. Down-regulation of 4.1B increased the metastatic propensity of poorly metastatic cells in an orthotopic model of prostate cancer. Furthermore, 4.1B-deficient mice displayed increased susceptibility for developing aggressive, spontaneous prostate carcinomas. In both cases, enhanced tumor malignancy was associated with reduced apoptosis. Because expression of Protein 4.1B is frequently down-regulated in human clinical prostate cancer, as well as in a spectrum of other tumor types, these results suggest a more general role for Protein 4.1B as a negative regulator of cancer progression to metastatic disease.
AU - Wong,SY
AU - Haack,H
AU - Kissil,JL
AU - Barry,M
AU - Bronson,RT
AU - Shen,SS
AU - Whittaker,CA
AU - Crowley,D
AU - Hynes,RO
DO - 10.1073/pnas.0705499104
EP - 12789
PY - 2007///
SN - 0027-8424
SP - 12784
TI - Protein 4.1B suppresses prostate cancer progression and metastasis.
T2 - Proc Natl Acad Sci U S A
UR - http://dx.doi.org/10.1073/pnas.0705499104
UR - https://www.ncbi.nlm.nih.gov/pubmed/17640904
VL - 104
ER -
For any enquiries related to the MRC Centre please contact:
Scientific Manager
Susannah Fisher
mrc.gida@imperial.ac.uk
External Relationships and Communications Manager
Dr Sabine van Elsland
s.van-elsland@imperial.ac.uk