BibTex format
@article{Oliver:2010:10.1101/gad.1897010,
author = {Oliver, TG and Mercer, KL and Sayles, LC and Burke, JR and Mendus, D and Lovejoy, KS and Cheng, M-H and Subramanian, A and Mu, D and Powers, S and Crowley, D and Bronson, RT and Whittaker, CA and Bhutkar, A and Lippard, SJ and Golub, T and Thomale, J and Jacks, T and Sweet-Cordero, EA},
doi = {10.1101/gad.1897010},
journal = {Genes Dev},
pages = {837--852},
title = {Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer.},
url = {http://dx.doi.org/10.1101/gad.1897010},
volume = {24},
year = {2010}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Chemotherapy resistance is a major obstacle in cancer treatment, yet the mechanisms of response to specific therapies have been largely unexplored in vivo. Employing genetic, genomic, and imaging approaches, we examined the dynamics of response to a mainstay chemotherapeutic, cisplatin, in multiple mouse models of human non-small-cell lung cancer (NSCLC). We show that lung tumors initially respond to cisplatin by sensing DNA damage, undergoing cell cycle arrest, and inducing apoptosis-leading to a significant reduction in tumor burden. Importantly, we demonstrate that this response does not depend on the tumor suppressor p53 or its transcriptional target, p21. Prolonged cisplatin treatment promotes the emergence of resistant tumors with enhanced repair capacity that are cross-resistant to platinum analogs, exhibit advanced histopathology, and possess an increased frequency of genomic alterations. Cisplatin-resistant tumors express elevated levels of multiple DNA damage repair and cell cycle arrest-related genes, including p53-inducible protein with a death domain (Pidd). We demonstrate a novel role for PIDD as a regulator of chemotherapy response in human lung tumor cells.
AU - Oliver,TG
AU - Mercer,KL
AU - Sayles,LC
AU - Burke,JR
AU - Mendus,D
AU - Lovejoy,KS
AU - Cheng,M-H
AU - Subramanian,A
AU - Mu,D
AU - Powers,S
AU - Crowley,D
AU - Bronson,RT
AU - Whittaker,CA
AU - Bhutkar,A
AU - Lippard,SJ
AU - Golub,T
AU - Thomale,J
AU - Jacks,T
AU - Sweet-Cordero,EA
DO - 10.1101/gad.1897010
EP - 852
PY - 2010///
SP - 837
TI - Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer.
T2 - Genes Dev
UR - http://dx.doi.org/10.1101/gad.1897010
UR - https://www.ncbi.nlm.nih.gov/pubmed/20395368
VL - 24
ER -