BibTex format
@article{Nusbaum:2005:10.1038/nature03983,
author = {Nusbaum, C and Zody, MC and Borowsky, ML and Kamal, M and Kodira, CD and Taylor, TD and Whittaker, CA and Chang, JL and Cuomo, CA and Dewar, K and FitzGerald, MG and Yang, X and Abouelleil, A and Allen, NR and Anderson, S and Bloom, T and Bugalter, B and Butler, J and Cook, A and DeCaprio, D and Engels, R and Garber, M and Gnirke, A and Hafez, N and Hall, JL and Norman, CH and Itoh, T and Jaffe, DB and Kuroki, Y and Lehoczky, J and Lui, A and Macdonald, P and Mauceli, E and Mikkelsen, TS and Naylor, JW and Nicol, R and Nguyen, C and Noguchi, H and O'Leary, SB and O'Neill, K and Piqani, B and Smith, CL and Talamas, JA and Topham, K and Totoki, Y and Toyoda, A and Wain, HM and Young, SK and Zeng, Q and Zimmer, AR and Fujiyama, A and Hattori, M and Birren, BW and Sakaki, Y and Lander, ES},
doi = {10.1038/nature03983},
journal = {Nature},
pages = {551--555},
title = {DNA sequence and analysis of human chromosome 18.},
url = {http://dx.doi.org/10.1038/nature03983},
volume = {437},
year = {2005}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Chromosome 18 appears to have the lowest gene density of any human chromosome and is one of only three chromosomes for which trisomic individuals survive to term. There are also a number of genetic disorders stemming from chromosome 18 trisomy and aneuploidy. Here we report the finished sequence and gene annotation of human chromosome 18, which will allow a better understanding of the normal and disease biology of this chromosome. Despite the low density of protein-coding genes on chromosome 18, we find that the proportion of non-protein-coding sequences evolutionarily conserved among mammals is close to the genome-wide average. Extending this analysis to the entire human genome, we find that the density of conserved non-protein-coding sequences is largely uncorrelated with gene density. This has important implications for the nature and roles of non-protein-coding sequence elements.
AU - Nusbaum,C
AU - Zody,MC
AU - Borowsky,ML
AU - Kamal,M
AU - Kodira,CD
AU - Taylor,TD
AU - Whittaker,CA
AU - Chang,JL
AU - Cuomo,CA
AU - Dewar,K
AU - FitzGerald,MG
AU - Yang,X
AU - Abouelleil,A
AU - Allen,NR
AU - Anderson,S
AU - Bloom,T
AU - Bugalter,B
AU - Butler,J
AU - Cook,A
AU - DeCaprio,D
AU - Engels,R
AU - Garber,M
AU - Gnirke,A
AU - Hafez,N
AU - Hall,JL
AU - Norman,CH
AU - Itoh,T
AU - Jaffe,DB
AU - Kuroki,Y
AU - Lehoczky,J
AU - Lui,A
AU - Macdonald,P
AU - Mauceli,E
AU - Mikkelsen,TS
AU - Naylor,JW
AU - Nicol,R
AU - Nguyen,C
AU - Noguchi,H
AU - O'Leary,SB
AU - O'Neill,K
AU - Piqani,B
AU - Smith,CL
AU - Talamas,JA
AU - Topham,K
AU - Totoki,Y
AU - Toyoda,A
AU - Wain,HM
AU - Young,SK
AU - Zeng,Q
AU - Zimmer,AR
AU - Fujiyama,A
AU - Hattori,M
AU - Birren,BW
AU - Sakaki,Y
AU - Lander,ES
DO - 10.1038/nature03983
EP - 555
PY - 2005///
SP - 551
TI - DNA sequence and analysis of human chromosome 18.
T2 - Nature
UR - http://dx.doi.org/10.1038/nature03983
UR - https://www.ncbi.nlm.nih.gov/pubmed/16177791
VL - 437
ER -