BibTex format
@article{Schiffler:2023:10.3390/microorganisms11122888,
author = {Schiffler, FB and Pereira, AHB and Moreira, SB and Arruda, IF and Moreira, FRR and D'arc, M and Claro, IM and Pissinatti, TDA and Cavalcante, LTDF and Miranda, TDS and Cosentino, MAC and de, Oliveira RC and Fernandes, J and Assis, MRDS and de, Oliveira JG and da, Silva TAC and Galliez, RM and Faffe, DS and de, Jesus JG and da, Silva MSB and Bezerra, MF and Ferreira, ODC and Tanuri, A and Castineiras, TM and Aguiar, RS and Faria, NR and de, Almeida AP and Pissinatti, A and Sabino, EC and Amendoeira, MRR and de, Lemos ERS and Ubiali, DG and Santos, AFA},
doi = {10.3390/microorganisms11122888},
journal = {Microorganisms},
title = {Lessons from a multilaboratorial task force for diagnosis of a fatal toxoplasmosis outbreak in captive primates in Brazil},
url = {http://dx.doi.org/10.3390/microorganisms11122888},
volume = {11},
year = {2023}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Toxoplasmosis is an important zoonotic disease caused by the parasite Toxoplasma gondii and is especially fatal for neotropical primates. In Brazil, the Ministry of Health is responsible for national epizootic surveillance, but some diseases are still neglected. Here, we present an integrated investigation of an outbreak that occurred during the first year of the COVID-19 pandemic among eleven neotropical primates housed at a primatology center in Brazil. After presenting non-specific clinical signs, all animals died within four days. A wide range of pathogens were evaluated, and we successfully identified T. gondii as the causative agent within four days after necropsies. The liver was the most affected organ, presenting hemorrhage and hepatocellular necrosis. Tachyzoites and bradyzoite cysts were observed in histological examinations and immunohistochemistry in different organs; in addition, parasitic DNA was detected through PCR in blood samples from all specimens evaluated. A high prevalence of Escherichia coli was also observed, indicating sepsis. This case highlights some of the obstacles faced by the current Brazilian surveillance system. A diagnosis was obtained through the integrated action of researchers since investigation for toxoplasmosis is currently absent in national guidelines. An interdisciplinary investigation could be a possible model for future epizootic investigations in animals.
AU - Schiffler,FB
AU - Pereira,AHB
AU - Moreira,SB
AU - Arruda,IF
AU - Moreira,FRR
AU - D'arc,M
AU - Claro,IM
AU - Pissinatti,TDA
AU - Cavalcante,LTDF
AU - Miranda,TDS
AU - Cosentino,MAC
AU - de,Oliveira RC
AU - Fernandes,J
AU - Assis,MRDS
AU - de,Oliveira JG
AU - da,Silva TAC
AU - Galliez,RM
AU - Faffe,DS
AU - de,Jesus JG
AU - da,Silva MSB
AU - Bezerra,MF
AU - Ferreira,ODC
AU - Tanuri,A
AU - Castineiras,TM
AU - Aguiar,RS
AU - Faria,NR
AU - de,Almeida AP
AU - Pissinatti,A
AU - Sabino,EC
AU - Amendoeira,MRR
AU - de,Lemos ERS
AU - Ubiali,DG
AU - Santos,AFA
DO - 10.3390/microorganisms11122888
PY - 2023///
SN - 2076-2607
TI - Lessons from a multilaboratorial task force for diagnosis of a fatal toxoplasmosis outbreak in captive primates in Brazil
T2 - Microorganisms
UR - http://dx.doi.org/10.3390/microorganisms11122888
UR - https://www.mdpi.com/2076-2607/11/12/2888
VL - 11
ER -