In this section
@article{Donnelly:1997:10.1098/rspb.1997.0229,
author = {Donnelly, CA and Ferguson, NM and Ghani, AC and Wilesmith, JW and Anderson, RM},
doi = {10.1098/rspb.1997.0229},
journal = {Proc Biol Sci},
pages = {1647--1656},
title = {Analysis of dam-calf pairs of BSE cases: confirmation of a maternal risk enhancement},
url = {http://dx.doi.org/10.1098/rspb.1997.0229},
volume = {264},
year = {1997}
}
TY - JOUR
AB - We investigate whether a calf born to a dam that develops bovine spongiform encephalopathy (BSE) (prior or subsequent to the birth) is itself at an enhanced risk of developing BSE. Analyses utilize the main database on reported BSE cases in the British cattle herd maintained by the Central Veterinary Laboratory in Weybridge to trace the dams of BSE-affected animals born following the ruminant feed ban in July 1988. The data reveal a significantly enhanced risk of disease in calves born to BSE-affected dams, with the risk being greatest when birth occurs after the onset of clinical signs of disease in the dam. The dependence of the maternally enhanced risk on the maternal incubation stage at birth argues for a significant component of direct maternal transmission of the aetiological agent of BSE, and offers little support for the hypothesis of genetic predisposition. Using a statistical likelihood model, we obtain estimates of the rate of direct maternal transmission by maternal incubation stage; however, biases in the available data make these values minimum estimates.
AU - Donnelly,CA
AU - Ferguson,NM
AU - Ghani,AC
AU - Wilesmith,JW
AU - Anderson,RM
DO - 10.1098/rspb.1997.0229
EP - 1656
PY - 1997///
SN - 0962-8452
SP - 1647
TI - Analysis of dam-calf pairs of BSE cases: confirmation of a maternal risk enhancement
T2 - Proc Biol Sci
UR - http://dx.doi.org/10.1098/rspb.1997.0229
UR - http://www.ncbi.nlm.nih.gov/pubmed/9404028
VL - 264
ER -
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