BibTex format
@article{de:2025:10.1016/j.lana.2025.101229,
author = {de, Lima STS and Claro, IM and Hua, X and Dejesus, R and Serres, K and Mello, LMS and Forato, J and Moreira, FRR and Kato, RB and Guimaraes, GN and Scachetti, GC and Andrade, PDS and Duarte, LMF and de, Lima MET and Ferraz, CPM and Vianna, MPN and Santiago, RM and Braga, ELR and Carneiro, IS and Firmino, ACL and Cabral, MG and Souza, C and Mello, LP and Li, S and Sabino, EC and Sallum, MAM and Weaver, SC and Faria, NR and Romano, CM and Dellicour, S and Proenca-Modena, JL and de, Souzaa WM},
doi = {10.1016/j.lana.2025.101229},
journal = {The Lancet Regional Health. Americas},
title = {Active West Nile virus transmission in Brazil: an epidemiological study},
url = {http://dx.doi.org/10.1016/j.lana.2025.101229},
volume = {51},
year = {2025}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - BackgroundWest Nile virus (WNV) is a mosquito-borne flavivirus that can cause neurological and fatal disease in animals and humans. Since its introduction into the USA in 1999, WNV has become the leading arbovirus in North America. In contrast, no major WNV outbreak has been reported in South America. Our study investigated active WNV circulation in Brazil.MethodsWe examined WNV epidemiological, molecular, genomic, and serological data from Brazil from January 2014 to December 2024. We also conducted WNV testing in 561 patients with febrile illness, neuroinvasive disease, or death between January 2019 and January 2024 in Ceará State, Brazil. Next, we conducted time series, mapping, ecological niche modeling, age-sex distribution, phylogenetic analyses, and statistical hypothesis tests.FindingsBetween January 2014 and December 2024, 110 West Nile cases were reported from 13 of 27 Brazilian states. In addition, our retrospective study in Ceará State revealed 12.1% (68 of 561 patients) were WNV cases, peaking in 2023, when 42.6% (29 of 68) of cases occurred. Among WNV cases, 7 (10.3%) had detected WNV RNA in serum, cerebrospinal fluid, or both, whereas 62 (89.7%) were IgM-positive, with 29 presenting with neurological complications, 35 with febrile illness, and four fatalities. WNV cases were reported in all months, with the highest numbers between May and August. Most cases were female (female-to-male ratio, 1.1:1), and the median age of patients was 40 years (interquartile range, 20–57). Our phylogenetic analysis showed that WNV lineage 1a circulated in Ceará State and caused a fatal horse case. Our ecological niche models identified several areas, mainly situated in the Northeast region, linked to a potentially higher risk of human exposure to local WNV circulation.InterpretationThese findings comprehensively described consistent WNV circulation in Brazil and may contribute to informing public health policy, focusing on the strategies to d
AU - de,Lima STS
AU - Claro,IM
AU - Hua,X
AU - Dejesus,R
AU - Serres,K
AU - Mello,LMS
AU - Forato,J
AU - Moreira,FRR
AU - Kato,RB
AU - Guimaraes,GN
AU - Scachetti,GC
AU - Andrade,PDS
AU - Duarte,LMF
AU - de,Lima MET
AU - Ferraz,CPM
AU - Vianna,MPN
AU - Santiago,RM
AU - Braga,ELR
AU - Carneiro,IS
AU - Firmino,ACL
AU - Cabral,MG
AU - Souza,C
AU - Mello,LP
AU - Li,S
AU - Sabino,EC
AU - Sallum,MAM
AU - Weaver,SC
AU - Faria,NR
AU - Romano,CM
AU - Dellicour,S
AU - Proenca-Modena,JL
AU - de,Souzaa WM
DO - 10.1016/j.lana.2025.101229
PY - 2025///
SN - 2667-193X
TI - Active West Nile virus transmission in Brazil: an epidemiological study
T2 - The Lancet Regional Health. Americas
UR - http://dx.doi.org/10.1016/j.lana.2025.101229
UR - https://www.sciencedirect.com/science/article/pii/S2667193X2500239X?via%3Dihub
VL - 51
ER -