In this section
@article{Williams:2025:10.1016/j.vaccine.2025.127856,
author = {Williams, LR and Voysey, M and Pollard, AJ and Grassly, NC},
doi = {10.1016/j.vaccine.2025.127856},
journal = {Vaccine},
title = {A statistical method for evaluating vaccine-induced immune correlates of protection against infection and disease progression: application to the ChAdOx1-S nCoV-19 phase 3 trial},
url = {http://dx.doi.org/10.1016/j.vaccine.2025.127856},
volume = {67},
year = {2025}
}
TY - JOUR
AB - Background: Correlates of protection (CoPs), defined as immune markers statistically correlated with vaccine efficacy (VE), can be used to accelerate vaccine development. Different components of the immune response may be important for protection against infection and against progression from asymptomatic infection to symptomatic or severe disease. However, CoPs are typically evaluated for these outcomes separately, which can lead to some CoPs not being identified. We propose a novel statistical framework for the integrated evaluation of CoPs for infections with multiple potential outcomes.Methods: We developed a model of the natural history of an infection that can identify CoPs at each stage of infection and disease progression and implemented this model in a Bayesian estimation framework. We validated the model on simulated data then applied it to individual-level clinical and serum neutralising and binding antibody data from COV002 (NCT04400838), a phase II/III trial of the ChAdOx1 nCoV-19 (AZD1222) vaccine. We explored logistic and non-parametric (cubic spline) relationships between VE and the candidate CoPs.Results: Both parametric and non-parametric forms of the model accurately estimated the relationships between the immune CoP and VE against infection (VEin) and against progression to symptoms given infection (VEpr) in 1000 simulated trial datasets. In the COV002 correlates subset (2227 participants, 5315 samples), SARS-CoV-2 spike-specific IgG was positively associated with both VEin and VEpr (average proportion of VE mediated by spike specific IgG, 27 % (95 % CI 2–88 %) for VEin and 41 % (95 % CI 0–96 %) for VEpr). Pseudoneutralisation antibody titres and receptor binding domain (RBD) specific serum IgG showed similar correlations.Conclusion: Integrated analysis of multiple disease outcomes and candidate CoPs enables the identification of CoPs that operate at different stages of disease progression, which are missed when evaluating outcomes se
AU - Williams,LR
AU - Voysey,M
AU - Pollard,AJ
AU - Grassly,NC
DO - 10.1016/j.vaccine.2025.127856
PY - 2025///
SN - 0264-410X
TI - A statistical method for evaluating vaccine-induced immune correlates of protection against infection and disease progression: application to the ChAdOx1-S nCoV-19 phase 3 trial
T2 - Vaccine
UR - http://dx.doi.org/10.1016/j.vaccine.2025.127856
UR - https://doi.org/10.1016/j.vaccine.2025.127856
VL - 67
ER -
For any enquiries related to the MRC Centre please contact:
Scientific Manager
Susannah Fisher
mrc.gida@imperial.ac.uk
External Relationships and Communications Manager
Dr Sabine van Elsland
s.van-elsland@imperial.ac.uk