BibTex format
@article{Telles-de-Deus:2026:10.1038/s41564-026-02302-w,
author = {Telles-de-Deus, J and Claro, IM and Bertanhe, M and Whittaker, C and Port-Carvalho, M and Rocha, EC and Coletti, TM and da, Silva CAM and Valença, IN and Lima-Camara, TN and Bicudo, de Paula M and Cunha, MS and de, Jesus JG and Dos, Santos Andrade P and Cox, V and de, Azevedo NCCF and Guerra, JM and Summa, JL and Teixeira, APP and Bergo, ES and Pereira, M and Moreira, FRR and Felix, AC and de, Paula AV and de, Araujo Eliodoro RH and da, Silva Lima M and de, Oliveira FM and de, Souza VR and Franco, LAM and Nardi, MS and Sanches, TC and da, Silva ETBC and Coimbra, AAC and Dos, Santos PR and Lima, de Gouveia K and Vilela, FESP and Hill, SC and Oliveira, DAG and Piedade, HM and Guimarães-Luiz, T and Abreu, CMG and Casoni, da Rocha G and Abade, L and de, Souza WM and Lambert, B and Pereira, de Souza R and Pinter, A and Sabino, EC and Mucci, LF and Faria, NR},
doi = {10.1038/s41564-026-02302-w},
journal = {Nat Microbiol},
pages = {877--891},
title = {Evolution and spillover dynamics of yellow fever at the forest-urban interface in Brazil.},
url = {http://dx.doi.org/10.1038/s41564-026-02302-w},
volume = {11},
year = {2026}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Yellow fever virus (YFV) continues to threaten human and wildlife populations in the Americas, yet its transmission at the forest-urban interface remains unclear. Here we integrate ground- and canopy-level mosquito surveillance, systematic monitoring of non-human primate carcasses and viral metagenomics to describe the dynamics of a sylvatic YFV outbreak in a 186-hectare Atlantic Forest fragment embedded within metropolitan São Paulo, Brazil, between 2017 and 2018. Our analyses reveal that transmission was primarily driven by a single genetic cluster introduced during a period of high abundance of the main vector, Haemagogus leucocelaenus mosquitoes. A near-complete hepatitis A virus genome was detected in a YFV-infected howler monkey, suggesting potential co-infections at the human-wildlife interface. Phylogenetic and epidemiological modelling estimated a basic reproduction number, R0, for sylvatic yellow fever of 8.2 (95% CI 5.1-12.2), substantially higher than previous estimates for urban outbreaks. Our findings demonstrate that multisource surveillance could provide actionable early warnings in regions at risk for zoonotic spillover.
AU - Telles-de-Deus,J
AU - Claro,IM
AU - Bertanhe,M
AU - Whittaker,C
AU - Port-Carvalho,M
AU - Rocha,EC
AU - Coletti,TM
AU - da,Silva CAM
AU - Valença,IN
AU - Lima-Camara,TN
AU - Bicudo,de Paula M
AU - Cunha,MS
AU - de,Jesus JG
AU - Dos,Santos Andrade P
AU - Cox,V
AU - de,Azevedo NCCF
AU - Guerra,JM
AU - Summa,JL
AU - Teixeira,APP
AU - Bergo,ES
AU - Pereira,M
AU - Moreira,FRR
AU - Felix,AC
AU - de,Paula AV
AU - de,Araujo Eliodoro RH
AU - da,Silva Lima M
AU - de,Oliveira FM
AU - de,Souza VR
AU - Franco,LAM
AU - Nardi,MS
AU - Sanches,TC
AU - da,Silva ETBC
AU - Coimbra,AAC
AU - Dos,Santos PR
AU - Lima,de Gouveia K
AU - Vilela,FESP
AU - Hill,SC
AU - Oliveira,DAG
AU - Piedade,HM
AU - Guimarães-Luiz,T
AU - Abreu,CMG
AU - Casoni,da Rocha G
AU - Abade,L
AU - de,Souza WM
AU - Lambert,B
AU - Pereira,de Souza R
AU - Pinter,A
AU - Sabino,EC
AU - Mucci,LF
AU - Faria,NR
DO - 10.1038/s41564-026-02302-w
EP - 891
PY - 2026///
SP - 877
TI - Evolution and spillover dynamics of yellow fever at the forest-urban interface in Brazil.
T2 - Nat Microbiol
UR - http://dx.doi.org/10.1038/s41564-026-02302-w
UR - https://www.ncbi.nlm.nih.gov/pubmed/41813975
VL - 11
ER -