BibTex format
@article{Manuli:2026:10.1038/s41591-026-04221-z,
author = {Manuli, ER and Hua, X and Scachetti, GC and Forato, J and Claro, IM and Pereira, GM and Sacchetto, L and Cortes-Azuero, O and Bernardo, AC and Resende, CF and Bacarov, NBS and Capuani, L and de, Lima STS and de, Jesus R and Kato, RB and Salgado, BB and Singh, CML and Pereira, NC and Reis, RS and Albuquerque, SRL and Stanton, R and Sampaio, VS and Bento, AI and Cunha, MP and Ratmann, O and Faria, NR and Weaver, SC and Lalwani, PJ and Salje, H and Costa, AG and Proenca-Modena, JL and Sabino, EC and de, Souza WM},
doi = {10.1038/s41591-026-04221-z},
journal = {Nat Med},
pages = {1383--1392},
title = {Transmission dynamics of Oropouche virus in Latin America and the Caribbean.},
url = {http://dx.doi.org/10.1038/s41591-026-04221-z},
volume = {32},
year = {2026}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Oropouche virus (OROV) is an arbovirus endemic to the Amazon region since the 1950s that re-emerged in late 2023, causing a major epidemic across Central and South America. Here we investigated the transmission dynamics of the 2023-2024 epidemic in Manaus City (Amazonas state, Brazil), a major metropolitan hub in the Amazon, and estimated OROV infections across Latin America and the Caribbean. OROV re-emergence in Manaus resulted in an increase of IgG seroprevalence from 11.4% in November 2023 to 25.7% in November 2024. The neutralizing capacity of OROV-specific IgG antibodies from individuals collected before and after the re-emergence demonstrated a median plaque reduction neutralization test 50% titer of 640 against both the historical and contemporary OROV isolates. A historical reconstruction of OROV circulation in Manaus indicated a continuous low-level transmission with two major outbreaks of comparable seasonality and magnitude in 1980-1981 and 2023-2024. We estimate approximately 336,000 OROV infections in the Amazon region under a scenario of continuous endemic transmission without major outbreaks and over 9.4 million OROV infections during major outbreaks from 1960 to 2025. Collectively, our findings provide a comprehensive assessment of OROV transmission in Manaus and contribute to a better understanding of the OROV burden.
AU - Manuli,ER
AU - Hua,X
AU - Scachetti,GC
AU - Forato,J
AU - Claro,IM
AU - Pereira,GM
AU - Sacchetto,L
AU - Cortes-Azuero,O
AU - Bernardo,AC
AU - Resende,CF
AU - Bacarov,NBS
AU - Capuani,L
AU - de,Lima STS
AU - de,Jesus R
AU - Kato,RB
AU - Salgado,BB
AU - Singh,CML
AU - Pereira,NC
AU - Reis,RS
AU - Albuquerque,SRL
AU - Stanton,R
AU - Sampaio,VS
AU - Bento,AI
AU - Cunha,MP
AU - Ratmann,O
AU - Faria,NR
AU - Weaver,SC
AU - Lalwani,PJ
AU - Salje,H
AU - Costa,AG
AU - Proenca-Modena,JL
AU - Sabino,EC
AU - de,Souza WM
DO - 10.1038/s41591-026-04221-z
EP - 1392
PY - 2026///
SP - 1383
TI - Transmission dynamics of Oropouche virus in Latin America and the Caribbean.
T2 - Nat Med
UR - http://dx.doi.org/10.1038/s41591-026-04221-z
UR - https://www.ncbi.nlm.nih.gov/pubmed/41876648
VL - 32
ER -