In this section
@article{Gupta:1998,
author = {Gupta, S and Ferguson, N and Anderson, R},
journal = {Science},
pages = {912--915},
title = {Chaos, persistence, and evolution of strain structure in antigenically diverse infectious agents},
url = {http://www.ncbi.nlm.nih.gov/pubmed/9572737},
volume = {280},
year = {1998}
}
TY - JOUR
AB - The effects of selection by host immune responses on transmission dynamics was analyzed in a broad class of antigenically diverse pathogens. Strong selection can cause pathogen populations to stably segregate into discrete strains with nonoverlapping antigenic repertoires. However, over a wide range of intermediate levels of selection, strain structure is unstable, varying in a manner that is either cyclical or chaotic. These results have implications for the interpretation of longitudinal epidemiological data on strain or serotype abundance, design of surveillance strategies, and the assessment of multivalent vaccine trials.
AU - Gupta,S
AU - Ferguson,N
AU - Anderson,R
EP - 915
PY - 1998///
SN - 0036-8075
SP - 912
TI - Chaos, persistence, and evolution of strain structure in antigenically diverse infectious agents
T2 - Science
UR - http://www.ncbi.nlm.nih.gov/pubmed/9572737
VL - 280
ER -
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