BibTex format
@article{Abdallat:2013,
author = {Abdallat, MM and Abroug, F and Al, Dhahry SHS and Alhajri, MM and Al-Hakeem, R and Al, Hosani FI and Al, Qasrawi SMA and Al-Romaihi, HE and Assiri, A and Baillie, JK and Ben, Embarek PK and Ben, Salah A and Blümel, B and Briese, T and Buchholz, U and Cognat, SBF and Defang, GN and De, La Rocque S and Donatelli, I and Drosten, C and Drury, PA and Eremin, SR and Ferguson, NM and Fontanet, A and Formenty, PBH and Fouchier, RAM and Gao, CQ and Garcia, E and Gerber, SI and Guery, B and Haagmans, BL and Haddadin, AJ and Hardiman, MC and Hensley, LE and Hugonnet, SAL and Hui, DSC and Isla, N and Karesh, WB and Koopmans, M and Kuehne, A and Lipkin, WI and Mafi, AR and Malik, M and Manuguerra, JC and Memish, Z and Mounts, AW and Mumford, E and Opoka, L and Osterhaus, A and John, Oxenford C and Pang, J and Pebody, R and Peiris, JSM and Jay, Plotkin B and Poumerol, G and Reusken, C and Rezza, G and Roth, CE and Shindo, N and Shumate, AM and Siwula, M and Slim, A and Smallwood, C and van, der Werf},
journal = {Plos Currents},
title = {State of knowledge and data gaps of middle east respiratory syndrome coronavirus (MERS-CoV) in humans},
volume = {5},
year = {2013}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - BACKGROUND: Between September 2012 and 22 October 2013, 144 laboratory-confirmed and 17 probable MERS-CoV cases from nine countries were notified to WHO. METHODS: We summarize what is known about the epidemiology, virology, phylogeny and emergence of MERS-CoV to inform public health policies. RESULTS: The median age of patients (n=161) was 50 years (range 14 months to 94 years), 64.5% were male and 63.4% experienced severe respiratory disease. 76.0% of patients were reported to have ≥1 underlying medical condition and fatal cases, compared to recovered or asymptomatic cases were more likely to have an underlying condition (86.8% vs. 42.4%, p<0.001). Analysis of genetic sequence data suggests multiple independent introductions into human populations and modelled estimates using epidemiologic and genetic data suggest R<inf>0</inf> is <1, though the upper range of estimates may exceed 1. Index/sporadic cases (cases with no epidemiologic-link to other cases) were more likely to be older (median 59.0 years vs. 43.0 years, p<0.001) compared to secondary cases, although these proportions have declined over time. 80.9% vs. 67.2% of index/sporadic and secondary cases, respectively, reported ≥1 underlying condition. Clinical presentation ranges from asymptomatic to severe pneumonia with acute respiratory distress syndrome and multi-organ failure. Nearly all symptomatic patients presented with respiratory symptoms and 1/3 of patients also had gastrointestinal symptoms. CONCLUSIONS: Sustained human-to-human transmission of MERS-CoV has not been observed. Outbreaks have been extinguished without overly aggressive isolation and quarantine suggesting that transmission of virus may be stopped with implementation of appropriate infection control measures.
AU - Abdallat,MM
AU - Abroug,F
AU - Al,Dhahry SHS
AU - Alhajri,MM
AU - Al-Hakeem,R
AU - Al,Hosani FI
AU - Al,Qasrawi SMA
AU - Al-Romaihi,HE
AU - Assiri,A
AU - Baillie,JK
AU - Ben,Embarek PK
AU - Ben,Salah A
AU - Blümel,B
AU - Briese,T
AU - Buchholz,U
AU - Cognat,SBF
AU - Defang,GN
AU - De,La Rocque S
AU - Donatelli,I
AU - Drosten,C
AU - Drury,PA
AU - Eremin,SR
AU - Ferguson,NM
AU - Fontanet,A
AU - Formenty,PBH
AU - Fouchier,RAM
AU - Gao,CQ
AU - Garcia,E
AU - Gerber,SI
AU - Guery,B
AU - Haagmans,BL
AU - Haddadin,AJ
AU - Hardiman,MC
AU - Hensley,LE
AU - Hugonnet,SAL
AU - Hui,DSC
AU - Isla,N
AU - Karesh,WB
AU - Koopmans,M
AU - Kuehne,A
AU - Lipkin,WI
AU - Mafi,AR
AU - Malik,M
AU - Manuguerra,JC
AU - Memish,Z
AU - Mounts,AW
AU - Mumford,E
AU - Opoka,L
AU - Osterhaus,A
AU - John,Oxenford C
AU - Pang,J
AU - Pebody,R
AU - Peiris,JSM
AU - Jay,Plotkin B
AU - Poumerol,G
AU - Reusken,C
AU - Rezza,G
AU - Roth,CE
AU - Shindo,N
AU - Shumate,AM
AU - Siwula,M
AU - Slim,A
AU - Smallwood,C
AU - van,der Werf S
AU - Van,Kerkhove MD
AU - Zambon,M
PY - 2013///
TI - State of knowledge and data gaps of middle east respiratory syndrome coronavirus (MERS-CoV) in humans
T2 - Plos Currents
VL - 5
ER -