Photo of pills and tablets

Recent years have seen a worrying increase in antimicrobial resistance (AMR), that is the ability of many pathogens to survive the treatments usually applied against the infections they cause. This includes resistance of bacteria to antibiotics, of viruses to antivirals, of fungi to antifungals, and of parasites to antiparasitics. Some infectious pathogens are getting dangerously close to resisting all known methods of treatment. Effectively tackling this problem requires to develop a better understanding of the epidemiological and evolutionary factors causing AMR to emerge and spread in pathogen populations. Researchers in the Centre are currently investigating resistance of malaria to antimalarial drugs used in Africa and South East Asia. Resistance of bacteria to antibiotics is another important focus, especially in Staphylococcus aureus, Streptococcus pneumoniae, Clostridium difficile, Mycobacterium tuberculosis, Neisseria gonorrhoeae and Enterobacteriaceae. We are building and implementing new mathematical models of AMR based on both epidemiological and genetic data to study the key processes and parameters involved in resistance dynamics. This modeling approach provides a solid basis for evaluating the potential effectiveness of proposed public health intervention measures.

Academic staff